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Leptin ve Diğer Hormonlar Üzerindeki Etkileri

Yıl 2015, Cilt 8, Sayı 1, 75 - 83, 01.06.2015

Öz

Leptinin etkilerinin anlaşılması hayvanlarla yapılan ve önemli ipuçları bırakmaya devam eden fizyoloji, metabolizma ve hücresel sinyalizasyon deneylerinden kaynaklanmıştır. Leptin keşfedilmesinden bu yana, bazı metabolitler ve hormonlar ile çeşitli yollarla bağlantılı olmuştur. Leptin özellikle kalori kısıtlaması ve açlığa uyum sırasında hipotalamus-hipofiz fonksiyonlarını etkiler. Leptindeki düşüş tiroid hormonu, büyüme hormonu ve cinsel hormonların salgılanmasını sınırlayarak ve kortizol salınımını artırarak enerji harcamasını azaltmak için bir sinyaldir. Bazı etkiler ön hipofiz hücreleri tarafından doğrudan leptini bağlayarak meydana gelebilmektedir. Ancak, leptin sinyaline esas olarak hipotalamik çekirdek içinde yer alan reseptörler aracılık eder. Ayrıca leptin bu dokularda bulunan leptin reseptörleri aracılığıyla tiroid ve böbreküstü bezi fonksiyonlarını düzenleyebilir. Son olarak, leptin dokulardan farklı adipokinlerin salgılanmasını değiştirebilir ve adipoz doku fonksiyonu üzerine doğrudan etkide bulunabilir. Böylece leptin metabolik bir sinyal olarak, birçok endokrin sistem üzerinde önemli düzenleyici etkilere sahiptir.

Kaynakça

  • Ahima RS, Flier JS. Leptin. Annu.Rev.Physiol. 2000; 62: 413-437.
  • Alikaşifoğlu A. Enerji metabolizmasının düzenlenmesinde hormonların ve nörotransmitterlerin rolü. Katkı Pediatri Dergisi. 2000; 21(4): 492-499.
  • Andrews J.F. Leptin: energy regulation and beyond to a hormone with pan-physiological function. Proc Nutr Soc. 1998; 57: 409-411.
  • Aslan K., Serdar Z., Tokullugil A. Multifonksiyonel Hormon: Leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2004; 30(2): 113-118.
  • Bocquier F, Bommet M, Faulconnier Y, Guerre-Millo M, Martin P, Chilliard Y. Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reprod Nutr Develop. 1998; 38: 489-498.
  • Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes. 1997; 46: 1235-1238.
  • Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996; 84: 491-495.
  • Chilliard Y, Bonnet M, Delavaud C, Faulconniera Y, Lerouxb C, Djianec J, Bocquierd F. Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Dom.Anim.Endocrinol. 2001; 21: 271-295.
  • Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG. Leptin acts in the central nervous system to produce dosedependent changes in arterial pressure. Hypertension. 2001; 37: 936-942.
  • Dagogo JS, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese andnonobese humans (abstract). Diabetes. 1996; 45: 695-698.
  • De Boer H, Blok G-J, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews. 1995; 16: 63-86.
  • Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y. Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J.Anim. Sci. 2002; 80: 1317-1328.
  • Emilsson V, Liu Y, Cawthorne MA, Morton NM. Devenport M. Expression and functional leptin receptor mRNA in pancreaticislets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997; 46: 313-316.
  • Ersoy E, Bayşu N. Biyokimya. Ankara Ünivesitesi Veteriner Fakültesi Yayınları No: 408. Ders Kitabı. 1986. S: 553-559.
  • Eryavuz A, Avci G, Celik HA, Kucukkurt I. Plasma leptin, insulin, glucose, and urea concentrations throughout lactation in dairy cows. Bull Vet Inst Pulawy. 2008; 52(3): 381-385.
  • Eryavuz A, Avci G, Kucukkurt I, Fidan AF. Comparison of plasma leptin, ınsulin and thyroid hormone concentrations and some biochemical parameters between fat-tailed and thin-tailed sheep breeds. Revue de Médecine Vétérinaire. 2007; 158(5): 244-249.
  • Escobar-Morreale HF, Escobar del Rey F, Morreale de Escobar G. Thyroid hormones influence serum leptin concentrations in the rat. Endocrinology. 1997; 138, 4485–4488.
  • Fain J, Coronel E, Beauchamp M, Bahouth S. Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states. Biochemical Journal. 1997; 322: 145–150.
  • Fei H, Okano HJ. Li C, Lee GH, Zhao C Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 1997; 94 (13): 7001-7005.
  • Florkowski CM, Collier GR, Zimmet PZ, Livesey JH, Espiner EA, Donald RA. Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol. 1996; 45: 769- 773.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mamals. Nature. 1998; 395: 763-770.
  • Gualillo O, Lago F, García M, Menéndez C, Señarís R, Casanueva FF, Diéguez C. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology; 1999; 140: 5149- 5153.
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  • Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E. et al. Augmented growth hormone secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. Journal of Clinical Endocrinology and Metabolism. 1992; 74: 757-765.
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  • Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health. Doi: 10.1177/0748233712469648. 2013.(Baskıda).
  • Kucukkurt I, Dundar Y. Effects of dietary Yucca schidigera supplementation on plasma leptin, insulin, iodated thyroid hormones and some biochemical parameters in rats. Revue de Medecine Veterinaire. 2013; 164(7): 362-367.
  • Küçükkurt İ. Diyete katılan farklı miktarlardaki Yucca schidigera tozunun sıçanlarda plazma leptin, insulin ve tiroid hormonları ile bazı biyokimyasal parametrelere etkilerinin araştırılması. Doktora Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar, 2007.
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The Effects of Leptin on Other Hormones

Yıl 2015, Cilt 8, Sayı 1, 75 - 83, 01.06.2015

Öz

Our understanding of the effects of leptin have stemmed mainly from animal studies, which continue to leave important clues of its roles in physiology, metabolism, and cell signaling. Since its discovery, leptin has been linked to various pathways with some metabolites and hormones. Leptin influences hypothalamic-pituitary function, particularly during the adaptation to caloric restriction and starvation. The fall in leptin is a signal to reduce energy expenditure by limiting thyroid hormone, growth hormone, and gonadal hormone secretion and by increasing cortisol release. The leptin signal is primarily mediated through receptors located within hypothalamic nuclei, although some effects may occur by leptin binding directly to cells of the anterior pituitary. Leptin may also regulate thyroid and adrenal gland function through leptin receptors located on these tissues. Finally, leptin has direct effects on adipose tissue function, which can alter secretion of various adipokines from the tissue. Thus leptin, as a signal of metabolic, has significant regulatory effects on many endocrine systems.

Kaynakça

  • Ahima RS, Flier JS. Leptin. Annu.Rev.Physiol. 2000; 62: 413-437.
  • Alikaşifoğlu A. Enerji metabolizmasının düzenlenmesinde hormonların ve nörotransmitterlerin rolü. Katkı Pediatri Dergisi. 2000; 21(4): 492-499.
  • Andrews J.F. Leptin: energy regulation and beyond to a hormone with pan-physiological function. Proc Nutr Soc. 1998; 57: 409-411.
  • Aslan K., Serdar Z., Tokullugil A. Multifonksiyonel Hormon: Leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2004; 30(2): 113-118.
  • Bocquier F, Bommet M, Faulconnier Y, Guerre-Millo M, Martin P, Chilliard Y. Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reprod Nutr Develop. 1998; 38: 489-498.
  • Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes. 1997; 46: 1235-1238.
  • Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996; 84: 491-495.
  • Chilliard Y, Bonnet M, Delavaud C, Faulconniera Y, Lerouxb C, Djianec J, Bocquierd F. Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Dom.Anim.Endocrinol. 2001; 21: 271-295.
  • Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG. Leptin acts in the central nervous system to produce dosedependent changes in arterial pressure. Hypertension. 2001; 37: 936-942.
  • Dagogo JS, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese andnonobese humans (abstract). Diabetes. 1996; 45: 695-698.
  • De Boer H, Blok G-J, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews. 1995; 16: 63-86.
  • Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y. Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J.Anim. Sci. 2002; 80: 1317-1328.
  • Emilsson V, Liu Y, Cawthorne MA, Morton NM. Devenport M. Expression and functional leptin receptor mRNA in pancreaticislets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997; 46: 313-316.
  • Ersoy E, Bayşu N. Biyokimya. Ankara Ünivesitesi Veteriner Fakültesi Yayınları No: 408. Ders Kitabı. 1986. S: 553-559.
  • Eryavuz A, Avci G, Celik HA, Kucukkurt I. Plasma leptin, insulin, glucose, and urea concentrations throughout lactation in dairy cows. Bull Vet Inst Pulawy. 2008; 52(3): 381-385.
  • Eryavuz A, Avci G, Kucukkurt I, Fidan AF. Comparison of plasma leptin, ınsulin and thyroid hormone concentrations and some biochemical parameters between fat-tailed and thin-tailed sheep breeds. Revue de Médecine Vétérinaire. 2007; 158(5): 244-249.
  • Escobar-Morreale HF, Escobar del Rey F, Morreale de Escobar G. Thyroid hormones influence serum leptin concentrations in the rat. Endocrinology. 1997; 138, 4485–4488.
  • Fain J, Coronel E, Beauchamp M, Bahouth S. Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states. Biochemical Journal. 1997; 322: 145–150.
  • Fei H, Okano HJ. Li C, Lee GH, Zhao C Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 1997; 94 (13): 7001-7005.
  • Florkowski CM, Collier GR, Zimmet PZ, Livesey JH, Espiner EA, Donald RA. Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol. 1996; 45: 769- 773.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mamals. Nature. 1998; 395: 763-770.
  • Gualillo O, Lago F, García M, Menéndez C, Señarís R, Casanueva FF, Diéguez C. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology; 1999; 140: 5149- 5153.
  • Güven Ş, El-Bershawi A, Sonnenberg GE, Wilson CR, Hoffmann RG, Krakower GR, Kissebah AH. Diabetes. 1999; 48: 347-352.
  • Haris RB. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem. Biophys. Res. Commun. 1998; 245 (2): 502-509.
  • Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E. et al. Augmented growth hormone secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. Journal of Clinical Endocrinology and Metabolism. 1992; 74: 757-765.
  • Harvey J, Mc Kenna F, Herson PS, Spanswick D, Ashford LJ. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J physiol. 1997; 504: 527-535.
  • Hekimoğlu A. Metabolik Sendromda Adiponektin. Harran Üniversitesi Tıp Fakültesi Dergisi. 2007; 4(2): 61-68.
  • Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: a review. J.Anim.Sci. 1998; 76: 1405-1420.
  • Houseknecht KL, Portocarrero CP, Ji S, Lemenager R, Spurlock ME. Growth hormone regulates leptin gene expression in bovine adipose IGF-1 expression. J Endocrinol. 2000; 164: 51-57.
  • Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004; 18: 439-456.
  • Iraklinaou S, Melidonis A, Tournis S, Konstandelou E, Tsatsoulis A, Elissaf M, Sideris D. Postprandial leptinresponses after an oral fat tolerance test. Diabetes Care. 2001; 24: 1299-1300.
  • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes. 2001; 50: 2438-2443.
  • Kauter K, Ball M, Kearney P, Tellam R, McFarlane JR. Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. J. Endocrinol. 2000; 166: 127-135.
  • Kielar D, Clark JS, Ciechanowicz A, Kurzawski G, Sulikowski T, Naruszewicz M. Leptin receptor isoforms expressed in human adipose tissue. Metabolism. 1998; 47: 844-847.
  • Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Hanry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro (abstract). Diabetes. 2001; 45: 699-701.
  • Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health. Doi: 10.1177/0748233712469648. 2013.(Baskıda).
  • Kucukkurt I, Dundar Y. Effects of dietary Yucca schidigera supplementation on plasma leptin, insulin, iodated thyroid hormones and some biochemical parameters in rats. Revue de Medecine Veterinaire. 2013; 164(7): 362-367.
  • Küçükkurt İ. Diyete katılan farklı miktarlardaki Yucca schidigera tozunun sıçanlarda plazma leptin, insulin ve tiroid hormonları ile bazı biyokimyasal parametrelere etkilerinin araştırılması. Doktora Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar, 2007.
  • Lengyel AM. Novel mechanisms of growth hormone regulation: growth hormone releasing peptides and ghrelin. Braz J Med Biol Res. 2006; 39: 1003-1011.
  • Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M. Grelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension. 2004; 43(5): 977-982.
  • Lönnqvist F, Wennlund A, Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obesity. 1997; 21: 255-260.
  • Madej T, Boguski MS, Bryant SH. Threading analysis suggest that the obese gene product may be a helical cytokine. FEBS Letters. 1995; 373: 13-18.
  • Malmström R, Taskinen MR, Karonen SL, Jarvinen HY. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia. 1996; 39: 993-996.
  • Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. International J. of Obesity. 2002; 26: 1407-1433.
  • Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002; 147: 173-180.
  • Medina-Gomez G, Rosa-Maria C, Maria-Jesus O. T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes. Biochimica et Biophysica Acta. 2004; 1682: 38-47.
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Ayrıntılar

Bölüm DERLEME
Yazarlar

İsmail KÜÇÜKKURT (Sorumlu Yazar)

Yayımlanma Tarihi 1 Haziran 2015
Yayınlandığı Sayı Yıl 2015, Cilt 8, Sayı 1

Kaynak Göster

Bibtex @derleme { kvj367578, journal = {Kocatepe Veterinary Journal}, issn = {1308-1594}, eissn = {2147-6853}, address = {}, publisher = {Afyon Kocatepe Üniversitesi}, year = {2015}, volume = {8}, number = {1}, pages = {75 - 83}, title = {The Effects of Leptin on Other Hormones}, key = {cite}, author = {Küçükkurt, İsmail} }
APA Küçükkurt, İ. (2015). The Effects of Leptin on Other Hormones . Kocatepe Veterinary Journal , 8 (1) , 75-83 . Retrieved from https://dergipark.org.tr/tr/pub/kvj/issue/32968/367578
MLA Küçükkurt, İ. "The Effects of Leptin on Other Hormones" . Kocatepe Veterinary Journal 8 (2015 ): 75-83 <https://dergipark.org.tr/tr/pub/kvj/issue/32968/367578>
Chicago Küçükkurt, İ. "The Effects of Leptin on Other Hormones". Kocatepe Veterinary Journal 8 (2015 ): 75-83
RIS TY - JOUR T1 - The Effects of Leptin on Other Hormones AU - İsmail Küçükkurt Y1 - 2015 PY - 2015 N1 - DO - T2 - Kocatepe Veterinary Journal JF - Journal JO - JOR SP - 75 EP - 83 VL - 8 IS - 1 SN - 1308-1594-2147-6853 M3 - UR - Y2 - 2015 ER -
EndNote %0 Kocatepe Veteriner Dergisi The Effects of Leptin on Other Hormones %A İsmail Küçükkurt %T The Effects of Leptin on Other Hormones %D 2015 %J Kocatepe Veterinary Journal %P 1308-1594-2147-6853 %V 8 %N 1 %R %U
ISNAD Küçükkurt, İsmail . "The Effects of Leptin on Other Hormones". Kocatepe Veterinary Journal 8 / 1 (Haziran 2015): 75-83 .
AMA Küçükkurt İ. The Effects of Leptin on Other Hormones. Kocatepe Veterinary Journal. 2015; 8(1): 75-83.
Vancouver Küçükkurt İ. The Effects of Leptin on Other Hormones. Kocatepe Veterinary Journal. 2015; 8(1): 75-83.
IEEE İ. Küçükkurt , "The Effects of Leptin on Other Hormones", Kocatepe Veterinary Journal, c. 8, sayı. 1, ss. 75-83, Haz. 2015

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