Kedi Ve Köpeklerde Laktatın Klinik Önemi

Yıl 2016, Cilt: 9 Sayı: 4, 353 - 356, 01.12.2016

Durmuş Fatih Başer Banu Karakaş Turan Civelek

Öz

Laktat organik nitelikte bir hidroksi asittir. Anaerobik glikolizis ürünüdür. LDH ve piruvat kullanımı laktat sentezinin tek yoludur. Bu sebeple, ortamdaki piruvat miktarı, laktat oluşumu için en önemli etkenidir. Kedi ve köpeklerde kan laktat değerlerinin ölçümünden hipovoleminin belirlenmesi, prognoz tayini, bazı hastalık gruplarında teşhisin konulması, şokun tanısı ve doku perfüzyonunun değerlendirilmesinde yararlanılır. Bu derlemede laktatın klinik öneminden bahsedilmiştir.

Anahtar Kelimeler

Köpek, Laktat, Laktik Asid, Prognoz

Clınıcal Sıgnıfıcance Of Lactate In Dogs And Cat

Öz

Lactate is a hydroxy acid in an organic nature. It is the product of anaerobic glycolysis. LDH and pyruvate using is the only way for synthesis of lactate. For that reason, the amount of pyruvate in the environment is the most important factor for the formation of lactate. Measurement of the blood lactate levels in cats and dogs is useful in evaluating of hypovolemia, determining of prognosis, diagnosis of the certain diseases and presence of the shock state and tissue perfusion evaluation. Clinical significance of lactate was mentioned in this review.

Anahtar Kelimeler

Dog, Lactate, Lactic acid, Prognosis

Kaynakça

• Anonim Usefulness of lactate measurement in practice. http://www.vettimes.co.uk/article/usefulness-of-lactate-measurement-in-practice/?format=pdf, Erişim tarihi: 22.06.2016
• Ateca LB, Dombrowski SC, Silverstein DC. Survival analysis of critically ill dogs with hypotension with or without hyperlactatemia: 67 cases (2006-2011). JAVMA. 2015; 246: 100-104.
• Bakker J, Gris P, Coffernils P, Kahn RJ, Vincent JL. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surgery. 1996; 171: 221-226.
• Beer KAS, Syring RS, Drobatz KJ. Evaluation of plasma lactate concentration and base excess at the time of hospital admission as predictors of gastric necrosis and outcome and correlation between those variables in dogs with gastric dilatation-volvulus: 78 cases (2004-2009). JAVMA. 2013; 242: 54-58.
• Bonczynski JJ, Ludwing LL, Barton LJ, Loar A, Peterson ME. Comparison of peritoneal fluid and peripheral blood pH, bicarbonate, glucose and lactate concentration as a diagnostic tool for septic peritonitis in dogs and cats. Vet Surg. 2003; 32: 161-166.
• De Papp E, Drobatz KJ, Hughes D. Plasma lactate concentration as a predictor of gastric necrosis and survival among dogs with gastric dilatation-volvulus: 102 cases. JAVMA. 1999; 215(1): 49-52.
• Dugdale A. Veterinary Anaesthesia. Wiley Blackwell. 2010; 232-243.
• Emiroğlu MB. Arteriyel switch ameliyatı yapılan büyük arter transpozisyonu vaklarında postoperatif kan laktat düzeylerinin prognoztik değeri. Uzmanlık Tezi, Ankara, 2011.
• Fall PJ, Szerlip HM. Lactic acidosis: from sour milk to septic shock. J Intensive Care Med. 2005; 20: 255-271.
• Green TI, Tonozzi CC, Kirby R, Rudloff E. Evaluation of initial plasma lactate values as a predictor of gastric necrosis and initial and subsequent plasma lactate values as a predictor of survival in dogs with gastric dilatation volvulus J Vet Emerg and Crit Care. 2011; 21: 36-44.
• Holahan ML, Brown AJ, Drobatz KJ. The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003–2006). J Vet Emerg and Crit Care. 2010; 20(4): 413-420.
• Hood VL. Lactic acidosis. In: Acid-Base Disorders and Their Treatment Ed. Gennari FJ, Adrogue HJ, Galla JH, Madias NE, 1st ed. Boca Raton, Taylor & Francis Group. 2005.
• Hughes D. Lactate measurement: diagnostic, therapeutic, and prognostic implications. In Kirk R, Bonagura JD., ed. Current Veterinary Therapy XIII: Small Animal Practice. Philadelphia: WB Saunders Company, 2000; 112-116.
• Kavaklı B, Sargın M, Gümüş M. Diabetes mellitus'un akut metabolik komplikasyonları: laktik asidoz. Kartal Eğitim ve Araştırma Klinikleri. 1998; 9:(1-4) 718-719.
• Luft FC. Lactic acidosis update for critical care clinicians. J Am Soc Nephrol. 2001; 17: 15-19.
• Michael S, Gregory K, Timothy B, Wayne E. Increased lactate concentrations in ill and injured dogs. J Vet Emerg and Crit Care. 1998; 8: 117–127.
• Nel M, Lobetti RG, Keller N, Thompson PN. Prognostic value of blood lactate, blood glucose and hematocrit in canine babesiosis. J Vet Intern Med. 2004; 18: 471-476.
• Reinke EL, Rees C, Drobatz KJ. Association of blood lactate concentration with physical perfusion variables, blood pressure, and outcome for cats treated at an emergency service. J Am Vet Med. 2015; 247(1): 79-84.
• Stevenson CK, Kidney BA, Duke T, Snead EC, Mainar- Jaime RC, Jackson ML. Serial blood lactate concentrations in systemically ill dogs. Vet Clin Path. 2007; 36: 234-239.
• Tynan B. Plasma lactate concentrations and comparison of two point of care lactate analysers to a laboratory analyser in a population of healthy cats. J Vet Emerg and Crit Care. 2015; 25: 521-527.