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Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?

Yıl 2018, Cilt: 11 Sayı: 4, 501 - 507, 15.12.2018
https://doi.org/10.30607/kvj.453321

Öz

Idiopathic hepatic
fibrosis (İHF) is an inevitable result of chronic liver disease progressing to
cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or
juvenile form in German Shepherd Dogs. However, few data have been published on
the incidence and prevalence of IHF in canine species. The case report presented
here describes idiopathic hepatic fibrosis in four neutered German Shephered
dogs
with a
familial relationship.
The main clinical complaints were
refractory ascites, variable appetite and progressive weight loss. Hepatic
fibrosis was confirmed with diagnostic applications and liver biopsy.
Nevertheless, all dogs died in spite of supportive and aggressive treatment.
Necropsy was performed in the dogs according to written owner consent. In
conclusion, the cases presented here reflect the congenital condition of
idiopathic hepatic fibrosis in young German Shepherd Dogs with
histopathological evidence. However, there was evidence of familial
relationship in the cases presented here. 

Kaynakça

  • Brown DL, Winkle TV, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 Dogs. Vet Pathol. 2010; 47: 102-107.
  • Desmet V. What is congenital hepatic fibrosis? Histopathol. 1998; 20: 465–477.
  • Center SA. Chronic liver disease: Current concepts of disease mechanisms. JSAP. 1999; 40: 106‐114.
  • Eulenberg VM, Lidbury JA. Hepatic fibrosis in dogs. J Vet Intern Med. 2018: 32; 26-41.
  • Favier RP. Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am: Smal An Pract. 2009: 39; 481-488.
  • Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 2000: 275(4); 2247-2250.
  • James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. AVJ, 2008; 86: 180-186.
  • Owczarczak S. Chronic Hepatic Fibrosis in an 8 year old French Bulldog. Seminar Paper, Cornell University College of Veterinary Medicine, USA, 2010.
  • Rutger HC, Haywood S, Kelly DF. Idiopathic hepatic fibrosis in 15 dogs. Vet Record. 1993; 133; 115-118.
  • Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagnostic Invest. 2000; 12: 101–110.

Dört Alman Çoban Köpeğinde Hepatik Fibroz İdiyopatik, Genetik Yatkınlık ya da Ailesel İlişki mi?

Yıl 2018, Cilt: 11 Sayı: 4, 501 - 507, 15.12.2018
https://doi.org/10.30607/kvj.453321

Öz

İdiyopatik hepatik
fibroz (İHF) siroza kadar gidebilen kronik karaciğer hastalığının kaçınılmaz
bir sonucudur. İdiyopatik hepatik fibroz, Alman Çoban Köpeklerinde jüvenil ya
da doğmasal olarak şekillenebilmektedir. Bununla birlikte, köpeklerde İHF’nin
prevalans veya insidansı hakkında az sayıda veri bulunmaktadır. Sunulan olgu
serisi, ailesel ilişkisi bulunan dört Alman Çoban Köpeğindeki idiyopatik
hepatik fibrozu tanımlamaktadır. Olgulardaki esas klinik şikayetler;
tekrarlayan asites, değişken iştah durumu ve ilerleyici kilo kaybıydı. Hepatik
fibroz tanısı diyagnostik uygulamalar ve karaciğer biyopsisi ile doğrulandı.
Destekleyici agresif tedaviye ragmen tüm köpekler kaybedildi. Hasta sahibinin
izni ile köpeklerde nekropsi gerçekleştirildi. Sonuç olarak, sunulan olgular
Alman Çoban Köpeklerinde histopatolojik kanıtı olan konjenital idiyopatik
hepatik fibrozu yansıtmaktadır. Bununla birlikte, sunulan olgularda ailesel
ilişki kanıtı da söz konusudur. 

Kaynakça

  • Brown DL, Winkle TV, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 Dogs. Vet Pathol. 2010; 47: 102-107.
  • Desmet V. What is congenital hepatic fibrosis? Histopathol. 1998; 20: 465–477.
  • Center SA. Chronic liver disease: Current concepts of disease mechanisms. JSAP. 1999; 40: 106‐114.
  • Eulenberg VM, Lidbury JA. Hepatic fibrosis in dogs. J Vet Intern Med. 2018: 32; 26-41.
  • Favier RP. Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am: Smal An Pract. 2009: 39; 481-488.
  • Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 2000: 275(4); 2247-2250.
  • James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. AVJ, 2008; 86: 180-186.
  • Owczarczak S. Chronic Hepatic Fibrosis in an 8 year old French Bulldog. Seminar Paper, Cornell University College of Veterinary Medicine, USA, 2010.
  • Rutger HC, Haywood S, Kelly DF. Idiopathic hepatic fibrosis in 15 dogs. Vet Record. 1993; 133; 115-118.
  • Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagnostic Invest. 2000; 12: 101–110.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm OLGU SUNUMU
Yazarlar

Hadi Alihosseini

Ekrem Çağatay Çolakoğlu

Ali Evren Haydardedeoğlu Bu kişi benim

Arif Kurtdede Bu kişi benim

Yayımlanma Tarihi 15 Aralık 2018
Kabul Tarihi 28 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 11 Sayı: 4

Kaynak Göster

APA Alihosseini, H., Çolakoğlu, E. Ç., Haydardedeoğlu, A. E., Kurtdede, A. (2018). Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. Kocatepe Veterinary Journal, 11(4), 501-507. https://doi.org/10.30607/kvj.453321
AMA Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. Aralık 2018;11(4):501-507. doi:10.30607/kvj.453321
Chicago Alihosseini, Hadi, Ekrem Çağatay Çolakoğlu, Ali Evren Haydardedeoğlu, ve Arif Kurtdede. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal 11, sy. 4 (Aralık 2018): 501-7. https://doi.org/10.30607/kvj.453321.
EndNote Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A (01 Aralık 2018) Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. Kocatepe Veterinary Journal 11 4 501–507.
IEEE H. Alihosseini, E. Ç. Çolakoğlu, A. E. Haydardedeoğlu, ve A. Kurtdede, “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”, kvj, c. 11, sy. 4, ss. 501–507, 2018, doi: 10.30607/kvj.453321.
ISNAD Alihosseini, Hadi vd. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal 11/4 (Aralık 2018), 501-507. https://doi.org/10.30607/kvj.453321.
JAMA Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. 2018;11:501–507.
MLA Alihosseini, Hadi vd. “Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?”. Kocatepe Veterinary Journal, c. 11, sy. 4, 2018, ss. 501-7, doi:10.30607/kvj.453321.
Vancouver Alihosseini H, Çolakoğlu EÇ, Haydardedeoğlu AE, Kurtdede A. Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?. kvj. 2018;11(4):501-7.

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