Araştırma Makalesi
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Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep

Yıl 2020, Cilt: 60 Sayı: 2, 68 - 73, 06.01.2021
https://doi.org/10.46897/livestockstudies.846425

Öz

Visna/maedi (VM) is an incurable viral disease of sheep causing serious production losses across the globe. Classical control measures against VM such as screening and culling are costly and time-consuming. Breeding VM resistant sheep could provide an opportunity for struggling with the VM and decreasing the economic loss. In this study, we aimed to investigate possible associations between two previously reported single nucleotide polymorphisms (SNPs) in the ovine DPPA2 and SYTL3 genes and VM serostatus, and evaluate implementation of selective breeding strategies against VM in Karacabey merino, Kivircik, Imroz, and composite breeds; Bandirma, Hampshire crosses (HAMP), Ramlic and Black-headed German mutton crosses (SBA) which are reared in Marmara region of Turkey. For this purpose, we genotyped the sheep which VM serostatus were determined previously. The genotyping results showed that these SNPs in the DPPA2 and SYTL3 genes are polymorphic. We have conducted an association analysis with an experimental design using case-control matched pairs. Finally, a power analysis was performed to determine the power of the statistical analysis. According to our findings, within our detection limits (the minimum odds ratio 2.5 to 2.8; CI 95; statistical power 0.96; p-value < 0.05), there was no significant association between the SNPs in the DPPA2 and SYTL3 genes and VM serostatus. Therefore, these SNP markers are not useful to selective breeding against VM in Turkish sheep.

Destekleyen Kurum

TAGEM

Proje Numarası

TAGEM/HAYSÜD/15/A01/P02/02-02

Teşekkür

This research has been funded by the Republic of Turkey Ministry of Agriculture and Forestry, General Directorate of Agricultural Research and Policies (Project number: TAGEM/HAYSÜD/15/A01/P02/02-02).

Kaynakça

  • Andrésdóttir, V. (2018). Maedi-Visna virus as a model for HIV. Icelandic Agricultural Sciences, 31(1), 23-47.
  • Ayelet, G., Roger, F., Tibbo, M., & Tembely, S. (2001). Survey of Maedi-Visna (MV) in Ethiopian Highland Sheep. Veterinary Journal, 161(2), 208-210.
  • Berriatua, E., Alvarez, V., Extramiana, B., González, L., Daltabuit, M., & Juste, R. (2003). Transmission and Control Implications of Seroconversion to Maedi-Visna Virus in Basque Dairy-Sheep Flocks. Preventive Veterinary Medicine, 60(4), 265-279.
  • Burgu, I., & Toker, A. (1990). Türkiye’de Visna-Maedi Enfeksiyonunun Serolojik Olarak Araştırılması. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 37(3), 538-553.
  • Cana, A., Taylor, N., Honhold, N., Gjinovci, V., Osmani, A., Nardelli, S., Murati, B., Spahiu, J., Mehmetukaj, D., & Alishani, M. (2020). Sero-Prevalence Survey of Small Ruminant Lentivirus (SRLV) Infections in Kosovo. Kafkas Universitesi Veteriner Fakultesi Dergisi, 26(1), 1-8.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A, G. (2009). Statistical Power Analyses Using G * Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149-1160.
  • Gomez-Lucia, E., Barquero, N., & Domenech, A. (2018). Maedi-Visna virus: current perspectives. Veterinary Medicine: Research and Reports, 9, 11–21.
  • Heaton, M. P., Clawson, M. L., Chitko-Mckown, C, G., Leymaster, K, A., Smith, T, P., Harhay, G, P., White, S, N., Herrmann-Hoesing, L, M., Mousel, M, R., Lewis, G, S., Kalbfleisch, T, S., Keen, J, E., & Laegreid, W, W. (2012). Reduced Lentivirus Susceptibility in Sheep with TMEM154 Mutations. PLoS Genetics, 8(1): e1002467
  • Heinrichs, R., Wilkins, W., Schroeder, G., & Campbell, J. (2017). Prevalence of Maedi-Visna in Saskatchewan Sheep. Canadian Veterinary Journal, 58(2), 183-186.
  • Herrmann-Hoesing, L, M., White, S, N., Mousel, M, R., Lewis, G, S., & Knowles, D, P. (2008). Ovine Progressive Pneumonia Provirus Levels Associate with Breed and Ovar-DRB1. Immunogenetics, 60(12), 749-758.
  • Huttner, K., Heyne, H., & Heim, D. (2017). Impact of flock segregation according to the Maedi-Visna status on reproduction and lamb rearing – a field study in Mecklenburg-Vorpommern. Berliner und Münchener Tierärztliche Wochenschrift, 130(11-12), 490-493.
  • Lago, N., López, C., Panadero, R., Cienfuegos, S., Pato, J., Prieto, A., Díaz, P., Mourazos, N., & Fernández, G. (2012). Seroprevalence and risk factors associated with Visna/Maedi virus in semi-ıntensive lamb-producing flocks in northwestern Spain. Preventive Veterinary Medicine, 103(2–3), 163-169.
  • Larruskain, A., Minguijón ,E., García-Etxebarria, K., Moreno, B., Arostegui, I., Juste, R, A., Jugo, B, M. (2010). MHC Class II DRB1 Gene Polymorphism in the Pathogenesis of Maedi–Visna and Pulmonary Adenocarcinoma Viral Diseases in Sheep. Immunogenetics, 62(2), 75-83.
  • Leymaster, K, A., Chitko-McKown, C, G., Clawson, M, L., Harhay, G, P., & Heaton, M, P. (2013). Effects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep. Journal of Animal Science, 91, 5114–5121.
  • Leymaster, K, A., Chitko-McKown, C, G., & Heaton, M, P. (2015). Incidence of infection in 39-month-old ewes with TMEM154 diplotypes “1 1,” “1 3,” and “3 3” after natural exposure to ovine progressive pneumonia virus. Journal of Animal Science, 93, 41–45.
  • McNemar, Q. (1947). Note on the sampling error of the difference between correlated proportions. Psychometrika, 12, 153-157.
  • Molaee, V., Eltanany, M., & Lühken, G. (2018). First survey on association of TMEM154 and CCR5 variants with serological maedi-visna status of sheep in German flocks. Veterinary Research, 49(1): 36.
  • Molaee, V., Otarod, V., Abdollahi, D., & Lühken, G. (2019). Lentivirus Susceptibility in Iranian and German Assessed by Determination of TMEM154 E35K. Animals, 9(9), 685.
  • Muz, D., Oğuzoğlu, T, C., Rosati, S., Reina, R., Bertolotti, L., & Burgu, I. (2013). First molecular characterization of visna / maedi viruses from naturally infected sheep in Turkey. Archives of Virology, 158(3), 559-570.
  • Ogden, N., Davies, P., & Lovatt, F. (2019). Dealing with maedi visna in UK sheep flocks. In Practice, 41(7), 321-328.
  • Pépin, M., Vitu, C., Russo, P., Mornex, J. F., & Peterhans, E. (1998). Maedi-visna virus infection in sheep: a review. Veterinary Research, 29(3-4), 341-367.
  • Peterhans, E., Greenland, T., Badiola, J., Harkiss, G., Bertoni, G., Amorena, B., Eliaszewicz, M., Juste, R. A., Krassnig, R., Lafont, J. P., Lenihan, P., Pétursson, G., Pritchard, G., Thorley, J., Vitu, C., Mornex, J. F., & Pépin, M. (2004). Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes. Veterinary Research, 35(3), 467-483.
  • Ruiz-Fons, F., González-Barrio, D., Aguilar-Ríos, F., Soler, A, J., Garde, J, J., Gortázar, C., & Fernández-Santos, Mdel, R. (2014). Infectious pathogens potentially transmitted by semen of the black variety of the Manchega sheep breed: Health constraints for conservation purposes. Animal Reproduction Science, 149(3-4), 152-157.
  • Sarafidou, T., Stamatis, C., Kalozoumi, G., Spyrou, V., Fthenakis, G, C., Billinis, C., & Mamuris, Z. (2013). Toll Like Receptor 9 (TLR9) Polymorphism G520R in Sheep Is Associated with Seropositivity for Small Ruminant Lentivirus. PLoS One, 8(5), e63901.
  • Tabet, E., Tlaige, R., El Hage, J., & Abi-Rizk, A. (2017). The occurrence of maedi-visna virus in Lebanon. Revue Scientifique et Technique, 36(3), 899-903.
  • White, S, N., Mousel, M, R., Herrmann-Hoesing, L, M., Reynolds, J, O., Leymaster, K, A., Neibergs, H, L., Lewis, G, S., & Knowles, D, P. (2012). Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus. PLoS One, 7(10): e47829.
  • White, S, N., Mousel, M, R., Reynolds, J, O., Herrmann-Hoesing, L, M., & Knowles, D, P. (2013). Deletion variant near ZNF389 is associated with control of ovine lentivirus in multiple sheep flocks. Animal Genetics, 45(2), 297-300.
  • White, S, N., Mousel, M, R., Reynolds, J, O., Lewis, G, S., & Herrmann-Hoesing, L, M. (2009). Common Promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus. Animal Genetics, 40(5), 583-589.
  • Yaman, Y., Keles, M., Aymaz, R., Sevim, S., Sezenler, T., Onaldi, T., Kaptan, C., Başkurt, A., Koncagül, S., Oner, Y., Oztürk, E, E., Iriadam, M., Un, C., & Heaton, M, P. (2019). Association of TMEM154 variants with visna/maedi virus infection in Turkish sheep. Small Ruminant Research, 177: 61–67.
  • Yavru, S., Şimşek, A., Bulut, O., & Kale, M. (2012). Konya bölgesi koyunlarında Maedi-Visna Virus enfeksiyonu üzerine serolojik araştırma. Eurasian Journal of Veterinary Sciences, 28(3), 142-148
Yıl 2020, Cilt: 60 Sayı: 2, 68 - 73, 06.01.2021
https://doi.org/10.46897/livestockstudies.846425

Öz

Proje Numarası

TAGEM/HAYSÜD/15/A01/P02/02-02

Kaynakça

  • Andrésdóttir, V. (2018). Maedi-Visna virus as a model for HIV. Icelandic Agricultural Sciences, 31(1), 23-47.
  • Ayelet, G., Roger, F., Tibbo, M., & Tembely, S. (2001). Survey of Maedi-Visna (MV) in Ethiopian Highland Sheep. Veterinary Journal, 161(2), 208-210.
  • Berriatua, E., Alvarez, V., Extramiana, B., González, L., Daltabuit, M., & Juste, R. (2003). Transmission and Control Implications of Seroconversion to Maedi-Visna Virus in Basque Dairy-Sheep Flocks. Preventive Veterinary Medicine, 60(4), 265-279.
  • Burgu, I., & Toker, A. (1990). Türkiye’de Visna-Maedi Enfeksiyonunun Serolojik Olarak Araştırılması. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 37(3), 538-553.
  • Cana, A., Taylor, N., Honhold, N., Gjinovci, V., Osmani, A., Nardelli, S., Murati, B., Spahiu, J., Mehmetukaj, D., & Alishani, M. (2020). Sero-Prevalence Survey of Small Ruminant Lentivirus (SRLV) Infections in Kosovo. Kafkas Universitesi Veteriner Fakultesi Dergisi, 26(1), 1-8.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A, G. (2009). Statistical Power Analyses Using G * Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149-1160.
  • Gomez-Lucia, E., Barquero, N., & Domenech, A. (2018). Maedi-Visna virus: current perspectives. Veterinary Medicine: Research and Reports, 9, 11–21.
  • Heaton, M. P., Clawson, M. L., Chitko-Mckown, C, G., Leymaster, K, A., Smith, T, P., Harhay, G, P., White, S, N., Herrmann-Hoesing, L, M., Mousel, M, R., Lewis, G, S., Kalbfleisch, T, S., Keen, J, E., & Laegreid, W, W. (2012). Reduced Lentivirus Susceptibility in Sheep with TMEM154 Mutations. PLoS Genetics, 8(1): e1002467
  • Heinrichs, R., Wilkins, W., Schroeder, G., & Campbell, J. (2017). Prevalence of Maedi-Visna in Saskatchewan Sheep. Canadian Veterinary Journal, 58(2), 183-186.
  • Herrmann-Hoesing, L, M., White, S, N., Mousel, M, R., Lewis, G, S., & Knowles, D, P. (2008). Ovine Progressive Pneumonia Provirus Levels Associate with Breed and Ovar-DRB1. Immunogenetics, 60(12), 749-758.
  • Huttner, K., Heyne, H., & Heim, D. (2017). Impact of flock segregation according to the Maedi-Visna status on reproduction and lamb rearing – a field study in Mecklenburg-Vorpommern. Berliner und Münchener Tierärztliche Wochenschrift, 130(11-12), 490-493.
  • Lago, N., López, C., Panadero, R., Cienfuegos, S., Pato, J., Prieto, A., Díaz, P., Mourazos, N., & Fernández, G. (2012). Seroprevalence and risk factors associated with Visna/Maedi virus in semi-ıntensive lamb-producing flocks in northwestern Spain. Preventive Veterinary Medicine, 103(2–3), 163-169.
  • Larruskain, A., Minguijón ,E., García-Etxebarria, K., Moreno, B., Arostegui, I., Juste, R, A., Jugo, B, M. (2010). MHC Class II DRB1 Gene Polymorphism in the Pathogenesis of Maedi–Visna and Pulmonary Adenocarcinoma Viral Diseases in Sheep. Immunogenetics, 62(2), 75-83.
  • Leymaster, K, A., Chitko-McKown, C, G., Clawson, M, L., Harhay, G, P., & Heaton, M, P. (2013). Effects of TMEM154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep. Journal of Animal Science, 91, 5114–5121.
  • Leymaster, K, A., Chitko-McKown, C, G., & Heaton, M, P. (2015). Incidence of infection in 39-month-old ewes with TMEM154 diplotypes “1 1,” “1 3,” and “3 3” after natural exposure to ovine progressive pneumonia virus. Journal of Animal Science, 93, 41–45.
  • McNemar, Q. (1947). Note on the sampling error of the difference between correlated proportions. Psychometrika, 12, 153-157.
  • Molaee, V., Eltanany, M., & Lühken, G. (2018). First survey on association of TMEM154 and CCR5 variants with serological maedi-visna status of sheep in German flocks. Veterinary Research, 49(1): 36.
  • Molaee, V., Otarod, V., Abdollahi, D., & Lühken, G. (2019). Lentivirus Susceptibility in Iranian and German Assessed by Determination of TMEM154 E35K. Animals, 9(9), 685.
  • Muz, D., Oğuzoğlu, T, C., Rosati, S., Reina, R., Bertolotti, L., & Burgu, I. (2013). First molecular characterization of visna / maedi viruses from naturally infected sheep in Turkey. Archives of Virology, 158(3), 559-570.
  • Ogden, N., Davies, P., & Lovatt, F. (2019). Dealing with maedi visna in UK sheep flocks. In Practice, 41(7), 321-328.
  • Pépin, M., Vitu, C., Russo, P., Mornex, J. F., & Peterhans, E. (1998). Maedi-visna virus infection in sheep: a review. Veterinary Research, 29(3-4), 341-367.
  • Peterhans, E., Greenland, T., Badiola, J., Harkiss, G., Bertoni, G., Amorena, B., Eliaszewicz, M., Juste, R. A., Krassnig, R., Lafont, J. P., Lenihan, P., Pétursson, G., Pritchard, G., Thorley, J., Vitu, C., Mornex, J. F., & Pépin, M. (2004). Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes. Veterinary Research, 35(3), 467-483.
  • Ruiz-Fons, F., González-Barrio, D., Aguilar-Ríos, F., Soler, A, J., Garde, J, J., Gortázar, C., & Fernández-Santos, Mdel, R. (2014). Infectious pathogens potentially transmitted by semen of the black variety of the Manchega sheep breed: Health constraints for conservation purposes. Animal Reproduction Science, 149(3-4), 152-157.
  • Sarafidou, T., Stamatis, C., Kalozoumi, G., Spyrou, V., Fthenakis, G, C., Billinis, C., & Mamuris, Z. (2013). Toll Like Receptor 9 (TLR9) Polymorphism G520R in Sheep Is Associated with Seropositivity for Small Ruminant Lentivirus. PLoS One, 8(5), e63901.
  • Tabet, E., Tlaige, R., El Hage, J., & Abi-Rizk, A. (2017). The occurrence of maedi-visna virus in Lebanon. Revue Scientifique et Technique, 36(3), 899-903.
  • White, S, N., Mousel, M, R., Herrmann-Hoesing, L, M., Reynolds, J, O., Leymaster, K, A., Neibergs, H, L., Lewis, G, S., & Knowles, D, P. (2012). Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus. PLoS One, 7(10): e47829.
  • White, S, N., Mousel, M, R., Reynolds, J, O., Herrmann-Hoesing, L, M., & Knowles, D, P. (2013). Deletion variant near ZNF389 is associated with control of ovine lentivirus in multiple sheep flocks. Animal Genetics, 45(2), 297-300.
  • White, S, N., Mousel, M, R., Reynolds, J, O., Lewis, G, S., & Herrmann-Hoesing, L, M. (2009). Common Promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus. Animal Genetics, 40(5), 583-589.
  • Yaman, Y., Keles, M., Aymaz, R., Sevim, S., Sezenler, T., Onaldi, T., Kaptan, C., Başkurt, A., Koncagül, S., Oner, Y., Oztürk, E, E., Iriadam, M., Un, C., & Heaton, M, P. (2019). Association of TMEM154 variants with visna/maedi virus infection in Turkish sheep. Small Ruminant Research, 177: 61–67.
  • Yavru, S., Şimşek, A., Bulut, O., & Kale, M. (2012). Konya bölgesi koyunlarında Maedi-Visna Virus enfeksiyonu üzerine serolojik araştırma. Eurasian Journal of Veterinary Sciences, 28(3), 142-148
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hayvansal Üretim (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Yalçın Yaman

Proje Numarası TAGEM/HAYSÜD/15/A01/P02/02-02
Yayımlanma Tarihi 6 Ocak 2021
Yayımlandığı Sayı Yıl 2020 Cilt: 60 Sayı: 2

Kaynak Göster

APA Yaman, Y. (2021). Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 60(2), 68-73. https://doi.org/10.46897/livestockstudies.846425
AMA Yaman Y. Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. Ocak 2021;60(2):68-73. doi:10.46897/livestockstudies.846425
Chicago Yaman, Yalçın. “Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association With Host Response Against Visna/Maedi Infection in Turkish Sheep”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 60, sy. 2 (Ocak 2021): 68-73. https://doi.org/10.46897/livestockstudies.846425.
EndNote Yaman Y (01 Ocak 2021) Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 60 2 68–73.
IEEE Y. Yaman, “Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep”, Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 60, sy. 2, ss. 68–73, 2021, doi: 10.46897/livestockstudies.846425.
ISNAD Yaman, Yalçın. “Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association With Host Response Against Visna/Maedi Infection in Turkish Sheep”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 60/2 (Ocak 2021), 68-73. https://doi.org/10.46897/livestockstudies.846425.
JAMA Yaman Y. Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2021;60:68–73.
MLA Yaman, Yalçın. “Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association With Host Response Against Visna/Maedi Infection in Turkish Sheep”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 60, sy. 2, 2021, ss. 68-73, doi:10.46897/livestockstudies.846425.
Vancouver Yaman Y. Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2021;60(2):68-73.