Propiltiourasil ile indüklenen p-ANCA+ pyoderma gangrenozum: Olgu sunumu ve literatürün gözden geçirilmesi

Yıl 2020, , 59 - 62, 30.08.2020

Sadettin Uslu , Aydan Köken Avşar , Ali Karakas

https://doi.org/10.35514/mtd.2020.30

Öz

Propiltiourasil (PTU), hipertiroidizm tedavisinde yaygın olarak kullanılan bir ilaçtır ve Graves hastalığı için tedavi edilen hastaların %20'sinde antinötrofil sitoplazmik antikorların (ANCA) gelişimi ile ilişkilidir [1], [2]. ANCA-pozitif PTU ile indüklenen pyoderma gangrenozum (PG) ilk olarak 1999'da Darben ve ark. [1]. ANCA'lar nekrotizan sistemik vaskülitli birçok hastanın kanında ve ilaca bağlı vaskülit, Sweet sendromu, Behçet hastalığı ve PG gibi nötrofilik dermatozlu bazı hastalarda bulunur. Bazı raporlar, PG'li hastalarda veya PG'nin özellikleri ile nötrofilik dermatozlu hastalarda ANCA fenomenini tanımlamıştır [3]. Bu olgu bazlı derleme ile uzun süredir PTU kullanan bir hastada p-ANCA pozitifliği olan PG gelişimini sunmayı ve güncel literatürü tartışmayı amaçladık.

Anahtar Kelimeler

ANCA, PTU, Pyoderma Gangrenosum

Propylthiouracil induced p-ANCA+ pyoderma gangrenosum: Case report and review of literature

Öz

Propylthiouracil (PTU) is a medication commonly used in the treatment of hyperthyroidism and is associated with the development of antineutrophil cytoplasmic antibodies (ANCA) in 20% of patients treated for Graves’ disease [1], [2]. ANCA-positive PTU-induced pyoderma gangrenosum (PG) was first identified in 1999 by Darben et al. [1]. ANCAs are found in the blood of many patients with necrotizing systemic vasculitis and in some patients with neutrophilic dermatoses such as drug-induced vasculitis, Sweet’s syndrome, Behçet's disease and PG. Some reports have described the ANCA phenomenon in patients with PG or in neutrophilic dermatosis with the characteristics of PG [3]. We aimed to present development of PG with p-ANCA positivity in a patient who had been using PTU for a long time and to discuss the current literature with this case-based review.

Anahtar Kelimeler

ANCA, PTU, Pyoderma Gangrenosum, Vasculitis

Kaynakça

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