Aljinatın biyomedikal alanlarda kullanımı
Yıl 2022,
Cilt: 4 Sayı: 1, 91 - 99, 30.06.2022
Sinem Uğur
,
Erkan Uğurlu
,
Eyüp İlker Saygılı
,
Önder Duysak
,
Selin Sayın
Öz
Aljinat, biyouyumluluk ve jelasyon kolaylığı gibi elverişli özelliklerinden dolayı biyomedikal, farmasötik, mühendislik gibi birçok uygulama alanlarına kolayca entegre edilebilen bir biyomalzemedir. Aljinat polimerleri, farmasötik tabanlı birçok uygulamada, doku mühendisliği (dokulardaki hücre dışı matrislere yapısal benzerliği koruması) uygulamaları kapsamında kullanılmaktadır. Bu derleme çalışmasında, aljinat, kimyasal yapısı, genel özellikleri, aljinat kaynakları morfolojik özellikleri, ekstraksiyon yöntemleri, özellikle biyomedikal alanda kullanımı hakkında bilgiler verilmesi amaçlanmıştır.
Kaynakça
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Alginate in usage biomedical areas
Yıl 2022,
Cilt: 4 Sayı: 1, 91 - 99, 30.06.2022
Sinem Uğur
,
Erkan Uğurlu
,
Eyüp İlker Saygılı
,
Önder Duysak
,
Selin Sayın
Öz
Alginate is a biomaterial that can be easily integrated into many application areas such as biomedical, pharmaceutical, engineering, due to its favorable properties such as biocompatibility and ease of gelation. Alginate polymers are used in tissue engineering (preserving structural similarity in tissues to extracellular matrices) applications in many pharmaceutical-based applications. In this review study, it is aimed to give information about alginate, its chemical structure, general properties, morphological properties of alginate sources, extraction methods, especially its use in the biomedical field.
Kaynakça
- Amadori, S., Torricelli, P., Panzavolta, S., Parrilli, A., Fini, M. & Bigi, A. (2015). Highly porous gelatin reinforced 3D scaffolds for articular cartilage regeneration. Macromolecular Bioscience, 15: 941-952. https://doi.org/10.1002/mabi.201500014
- Andersen, T., Strand, B. L., Formo, K., Alsberg, E. & Christensen, B.E. (2012). Alginates as Biomaterials in Tissue Engineering. In Carbohydrate Chemistry: Chemical and Biological Approaches, 37: 227-258. https://doi.org/10.1039/9781849732765-00227
- Annabi, N., Nichol, J. W. & Zhong, X. (2010). Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Engineering Part B: Reviews, 16: 371-383. https://doi.org/10.1089/ten.TEB.2009.0639
- Bidarra, S. J., Barrias, C. C., Barbosa, M. A., Soares, R. & Granja, P. L. (2010). Immobilization of human mesenchymal stem cells within RGD-grafted alginate microspheres and assessment of their angiogenic potential. Biomacromolecules, 11: 1956–64. https://doi.org/10.1021/bm100264a
- Boateng, J.S., Matthews, K. H., Stevens, H.N.E. & Eccleston, G.M. (2008). Wound healing dressings and drug delivery systems: A review. Journal of Pharmaceutical Sciences, 97: 2892-923. https://doi.org/10.1002/jps.21210
- Boontheekul, T., Kong, H. J. & Mooney, D. J. (2005). Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials, 26: 2455-2465. https://doi.org/10.1016/j.biomaterials.2004.06.044
- Bouhadir, K. H., Alsberg, E. & Mooney, D. J. (2001). Hydrogels for combination delivery of antineoplastic agents. Biomaterials, 22: 2625-2633. https://doi.org/10.1016/s0142-9612(01)00003-5
- Chang, S. C. N., Rowley, J. A., Tobias, G., Genes, N. G., Roy, A. K., Mooney, D. J., Vacanti, C. A. & Bonassar, L. J. (2001). Injection molding of chondrocyte/alginate constructs in the shape of facial implants. Journal of Biomedical Materials Research, 55: 503-511. https://doi.org/10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S
- Chang, S. C. N., Tobias, G., Roy, A. K., Vacanti, C. A. & Bonassar, L. J. (2003). Tissue engineering of autologous cartilage for craniofacial reconstruction by injection molding. Plastic and Reconstructive Surgery, 112: 793-799. https://doi.org/10.1097/01.PRS.0000069711.31021.94
- Chater, P. I., Wilcox, M. D., Brownlee, I. A., & Pearson, J. P. (2015). Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin. Carbohydrate Polymers, 131: 142-151. https://doi.org/10.1016/j.carbpol.2015.05.062
- Chu, T. M., Orton, D. G., Hollister, S. J., Feinberg, S. E. & Halloran, J. W. (2002). Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures. Biomaterials, 23: 1283-1293. https://doi.org/10.1016/S0142-9612(01)00243-5
- Coluccino, L., Stagnaro, P., Vassalli, M., & Scaglione, S. (2016). Bioactive TGF-β1/HA alginate-based scaffolds for osteochondral tissue repair: design, realization and multilevel characterization. Journal of Applied Biomaterials & Functional Materials, 14(1): 42-52. https://doi.org/10.5301/jabfm.5000249
- Draget, K. I., Smidsrød, O., & Skjåk-Bræk, G. (2005). Alginates from algae. In: Polysaccharides and polyamides in the food industry: properties, production, and patents, 1-30.
- Eming, S.A., Martin, P. & Tomic-Canic, M. (2014). Wound repair and regeneration: Mechanisms, signaling, and translation. Science Translational Medicine, 6: 265-266. https://doi.org/10.1126/scitranslmed.3009337
- Eslahi, N., Abdorahim, M. & Simchi, A. (2016). Smart Polymeric Hydrogels for Cartilage Tissue Engineering: A Review on the Chemistry and Biological Functions. Biomacromolecules, 17(11): 3441-3463. https://doi.org/10.1021/acs.biomac.6b01235
- Fischbach, C., Kong, H. J., Hsiong, S. X., Evangelista, M. B., Yuen, W., Mooney D. J. (2009). Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proceedings of the National Academy of Sciences, 106: 399-404. https://doi.org/10.1073/pnas.0808932106
- Florczyk, S. J., Kim, D. J., Wood, D. L. & Zhang, M. (2011). Influence of processingparameters on pore structure of 3D porous chitosan-alginate polyelectrolytecomplex scaffolds. Journal of Biomedical Materials Research Part A, 98(A): 614–620. https://doi.org/10.1002/jbm.a.33153
- Frykberg, R. G. & Banks, J. (2015). Challenges in the treatment of chronic wounds. Advances in Wound Care (New Rochelle), 4: 560-582. https://doi.org/10.1002/jbm.a.33153
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