Araştırma Makalesi
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Kanser hastalarında aşılanma durumu ve aşılanmayı etkileyen faktörlerin değerlendirilmesi

Yıl 2022, , 236 - 241, 31.12.2022
https://doi.org/10.30565/medalanya.1094182

Öz

Amaç: COVID-19 pandemisi, doğrudan enfeksiyona yol açarak veya sağlık sisteminde aksamayla beraber sekonder olarak kanser hastalarının ölüm oranını artırdı. SARS-CoV-2’nin yol açtığı enfeksiyona karşı etkili aşıların geliştirilmesinden sonar ölüm oranları düştü. Bu çalışmada kanser hastalarının aşı olup olmadığını incelemeye çalıştık.

Yöntemler: Türkiye’de iki medikal onkoloji merkezindeki hastaların aşıya yönelik tutumları ve aşılamayı etkileyen faktörleri araştırmak amacıyla kanserli hastalara anket uygulandı.

Bulgular: Çalışmaya iki yüz yetmiş bir hasta dahil edildi. Hastaların aşıya yönelik tutumlarında kanser türüne göre farklılık gözlenmedi. Hastaların %83’ü COVID-19’a karşı aşılanmıştı. Çalışma popülasyonunun %75’ine mümkün olan en kısa sürede aşı uygulanmıştı. Çalışma grubunda aşıdan kaçınmanın en önemli nedeni kemoterapi almaktı (p=0,002). Yeterli dozda aşısı olan ve olmayan hastalar arasında COVID-19 tedavisinin türü açısından anlamlı bir fark yoktu. Aşılamayı etkileyen en olumsuz faktör aktif kemoterapi tedavisiydi. Sosyal ilişkiler ve geleneksel medya aşılama için en olumlu etkenlerdi.

Sonuç: Tedavi gören veya remisyonda olan hastalar için aşılanma hayati önem taşımaktadır. Hastalar kemoterapi alacak olsalar bile aşı konusunda bilgilendirilmeli ve aşı için teşvik edilmelidir.

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

Uzm.Dr.Yonca Yılmaz Ürün'e desteklerinden dolayı teşekkür ederiz.

Kaynakça

  • 1. Lin CN, Chan KR, Ooi EE, Chiou MT, Hoang M, Hsueh PR, et al. Animal Coronavirus Diseases: Parallels with COVID-19 in Humans. Viruses. 2021;13(8):1507. doi: 10.3390/v13081507.
  • 2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
  • 3. GLOBOCAN 2020: New Global Cancer Data UICC. Available from: https://www.uicc.org/news/globocan-2020-new-global-cancer-data(01.03.2022)
  • 4. Hijano DR, Maron G, Hayden RT. Respiratory viral infections in patients with cancer or undergoing hematopoietic cell transplant. Front Microbiol. 2018;9:3097. doi: 10.3389/fmicb.2018.03097. PMID: 30619176.
  • 5. Bitterman R, Eliakim-Raz N, Vinograd I, Zalmanovici Trestioreanu A, Leibovici L, Paul M. Influenza vaccines in immunosuppressed adults with cancer. Cochrane Database Syst Rev. 2018;2(2):CD008983. doi: 10.1002/14651858.CD008983.pub3.
  • 6. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020;10(6):783-791. doi: 10.1158/2159-8290.CD-20-0422.
  • 7. Beypinar I, Urun M. Intravenous chemotherapy adherence of cancer patients in time of covid-19 crisis. UHOD. 2020;30(3):133–8. doi: 10.4999/uhod.204528.
  • 8. https://www.nccn.org/docs/default-source/COVID-19-19/COVID-19-vaccine-and-cancer-05.pdf?sfvrsn=45cc3047_2 (01.03.2022)
  • 9. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-15. doi: 10.1056/NEJMoa2034577.
  • 10. Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021;384(5):403-16. doi: 10.1056/NEJMoa2035389.
  • 11. Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, et al. Interim Results of a Phase 1-2a Trial of Ad26.COV2. S Covid-19 Vaccine. N Engl J Med. 2021;384(19):1824-35. doi: 10.1056/NEJMoa2034201.
  • 12. https://COVID-1919asi.saglik.gov.tr/TR-77707/asi-uygulanacak-grup-siralamasi.html%20 linkinde(01.03.2022)
  • 13. Kowalski J, Marchlewska M, Molenda Z, Górska P, Gawęda Ł. Adherence to safety and self-isolation guidelines, conspiracy and paranoia-like beliefs during COVID-19 pandemic in Poland - associations and moderators. Psychiatry Res. 2020;294:113540. doi: 10.1016/j.psychres.2020.113540.
  • 14. Freeman D, Waite F, Rosebrock L, Petit A, Causier C, East A, et al. Coronavirus conspiracy beliefs, mistrust, and compliance with government guidelines in England. Psychol Med. 2022;52(2):251-263. doi: 10.1017/S0033291720001890.
  • 15. Smith LE, Amlôt R, Weinman J, Yiend J, Rubin GJ. A systematic review of factors affecting vaccine uptake in young children. Vaccine. 2017;35(45):6059-69. doi: 10.1016/j.vaccine.2017.09.046.
  • 16. Kelkar AH, Blake JA, Cherabuddi K, Cornett H, McKee BL, Cogle CR. Vaccine Enthusiasm and Hesitancy in Cancer Patients and the Impact of a Webinar. Healthcare (Basel). 2021;9(3):351. doi: 10.3390/healthcare9030351.
  • 17. Ariza-Heredia EJ, Azzi J, Shah DP, Nesher L, Ghantoji SS, Michailidis L, et al. Influenza vaccination in patients with cancer: factors associated with vaccination practices for patients and their household members. Infect Control Hosp Epidemiol. 2015;36(10):1239-41. doi: 10.1017/ice.2015.150.
  • 18. Poeppl W, Lagler H, Raderer M, Sperr WR, Zielinski C, Herkner H, et al. Influenza vaccination perception and coverage among patients with malignant disease. Vaccine. 2015;33(14):1682-7. doi: 10.1016/j.vaccine.2015.02.029.
  • 19. Vollaard A, Schreuder I, Slok-Raijmakers L, Opstelten W, Rimmelzwaan G, Gelderblom H. Influenza vaccination in adult patients with solid tumours treated with chemotherapy. Eur J Cancer. 2017;76:134-43. doi: 10.1016/j.ejca.2017.02.012.
  • 20. Chun JY, Kim SI, Park EY, Park SY, Koh SJ, Cha Y, et al. Cancer Patients' Willingness to Take COVID-19 Vaccination: A Nationwide Multicenter Survey in Korea. Cancers (Basel). 2021;13(15):3883. doi: 10.3390/cancers13153883.
  • 21. https://covid19asi.saglik.gov.tr/ (01.03.2022)

The evaluation of vaccination status and the factors affecting vaccination in cancer patients

Yıl 2022, , 236 - 241, 31.12.2022
https://doi.org/10.30565/medalanya.1094182

Öz

Aim: Coronavirus disease 2019 (COVID-19) pandemic increased the mortality of cancer patients by causing direct infection or collateral damage to the healthcare system. After the development of effective vaccines against COVID-19 infection, mortality rates declined. In this study, we try to investigate the vaccination among cancer patients.

Methods: A survey was applied to patients with cancer in order to investigate the attitudes towards vaccination and the factors effecting vaccination in two medical oncology centers in Turkey.

Results: 271 patients were included in the study. No difference was observed in the attitudes of patients towards vaccination according to cancer type. 83% of the patients were vaccinated against COVID-19. In 75% of the study population, vaccine was administered in the earliest available time. Receiving chemotherapy was the most significant reason to avoid vaccination among the study group (p=0,002). There was no significant difference in terms of treatment type for COVID-19 between patients with or without adequate vaccination. The most negative factor affecting vaccination was active chemotherapy treatment. Social relations and traditional media were the most positive factors for vaccination.

Discussion: Vaccination is of vital importance for patients who are treated or on remission. Even if patients are to receive chemotherapy, they should be informed about vaccination and should be encouraged for vaccination.

Proje Numarası

yok

Kaynakça

  • 1. Lin CN, Chan KR, Ooi EE, Chiou MT, Hoang M, Hsueh PR, et al. Animal Coronavirus Diseases: Parallels with COVID-19 in Humans. Viruses. 2021;13(8):1507. doi: 10.3390/v13081507.
  • 2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
  • 3. GLOBOCAN 2020: New Global Cancer Data UICC. Available from: https://www.uicc.org/news/globocan-2020-new-global-cancer-data(01.03.2022)
  • 4. Hijano DR, Maron G, Hayden RT. Respiratory viral infections in patients with cancer or undergoing hematopoietic cell transplant. Front Microbiol. 2018;9:3097. doi: 10.3389/fmicb.2018.03097. PMID: 30619176.
  • 5. Bitterman R, Eliakim-Raz N, Vinograd I, Zalmanovici Trestioreanu A, Leibovici L, Paul M. Influenza vaccines in immunosuppressed adults with cancer. Cochrane Database Syst Rev. 2018;2(2):CD008983. doi: 10.1002/14651858.CD008983.pub3.
  • 6. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020;10(6):783-791. doi: 10.1158/2159-8290.CD-20-0422.
  • 7. Beypinar I, Urun M. Intravenous chemotherapy adherence of cancer patients in time of covid-19 crisis. UHOD. 2020;30(3):133–8. doi: 10.4999/uhod.204528.
  • 8. https://www.nccn.org/docs/default-source/COVID-19-19/COVID-19-vaccine-and-cancer-05.pdf?sfvrsn=45cc3047_2 (01.03.2022)
  • 9. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-15. doi: 10.1056/NEJMoa2034577.
  • 10. Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021;384(5):403-16. doi: 10.1056/NEJMoa2035389.
  • 11. Sadoff J, Le Gars M, Shukarev G, Heerwegh D, Truyers C, de Groot AM, et al. Interim Results of a Phase 1-2a Trial of Ad26.COV2. S Covid-19 Vaccine. N Engl J Med. 2021;384(19):1824-35. doi: 10.1056/NEJMoa2034201.
  • 12. https://COVID-1919asi.saglik.gov.tr/TR-77707/asi-uygulanacak-grup-siralamasi.html%20 linkinde(01.03.2022)
  • 13. Kowalski J, Marchlewska M, Molenda Z, Górska P, Gawęda Ł. Adherence to safety and self-isolation guidelines, conspiracy and paranoia-like beliefs during COVID-19 pandemic in Poland - associations and moderators. Psychiatry Res. 2020;294:113540. doi: 10.1016/j.psychres.2020.113540.
  • 14. Freeman D, Waite F, Rosebrock L, Petit A, Causier C, East A, et al. Coronavirus conspiracy beliefs, mistrust, and compliance with government guidelines in England. Psychol Med. 2022;52(2):251-263. doi: 10.1017/S0033291720001890.
  • 15. Smith LE, Amlôt R, Weinman J, Yiend J, Rubin GJ. A systematic review of factors affecting vaccine uptake in young children. Vaccine. 2017;35(45):6059-69. doi: 10.1016/j.vaccine.2017.09.046.
  • 16. Kelkar AH, Blake JA, Cherabuddi K, Cornett H, McKee BL, Cogle CR. Vaccine Enthusiasm and Hesitancy in Cancer Patients and the Impact of a Webinar. Healthcare (Basel). 2021;9(3):351. doi: 10.3390/healthcare9030351.
  • 17. Ariza-Heredia EJ, Azzi J, Shah DP, Nesher L, Ghantoji SS, Michailidis L, et al. Influenza vaccination in patients with cancer: factors associated with vaccination practices for patients and their household members. Infect Control Hosp Epidemiol. 2015;36(10):1239-41. doi: 10.1017/ice.2015.150.
  • 18. Poeppl W, Lagler H, Raderer M, Sperr WR, Zielinski C, Herkner H, et al. Influenza vaccination perception and coverage among patients with malignant disease. Vaccine. 2015;33(14):1682-7. doi: 10.1016/j.vaccine.2015.02.029.
  • 19. Vollaard A, Schreuder I, Slok-Raijmakers L, Opstelten W, Rimmelzwaan G, Gelderblom H. Influenza vaccination in adult patients with solid tumours treated with chemotherapy. Eur J Cancer. 2017;76:134-43. doi: 10.1016/j.ejca.2017.02.012.
  • 20. Chun JY, Kim SI, Park EY, Park SY, Koh SJ, Cha Y, et al. Cancer Patients' Willingness to Take COVID-19 Vaccination: A Nationwide Multicenter Survey in Korea. Cancers (Basel). 2021;13(15):3883. doi: 10.3390/cancers13153883.
  • 21. https://covid19asi.saglik.gov.tr/ (01.03.2022)
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Muslih Ürün 0000-0002-9883-3398

İsmail Beypınar 0000-0002-0853-4096

Sena Ece Davarcı 0000-0003-1142-9411

Hacer Demir 0000-0003-1235-9363

Meltem Baykara 0000-0003-3291-8134

Proje Numarası yok
Yayımlanma Tarihi 31 Aralık 2022
Gönderilme Tarihi 29 Mart 2022
Kabul Tarihi 29 Ekim 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

Vancouver Ürün M, Beypınar İ, Davarcı SE, Demir H, Baykara M. The evaluation of vaccination status and the factors affecting vaccination in cancer patients. Acta Med. Alanya. 2022;6(3):236-41.

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