Orbital and Ocular Adnexal Lymphomas: A Retrospective Single Center Study

Yıl 2022, , 315 - 319, 31.12.2022

Burak Ulaş , Altan Özcan , Astan İbayev

https://doi.org/10.30565/medalanya.1126423

Cited By: 1

Öz

Aim: To evaluate and present the clinical and histopathologic features of patients with orbital and adnexal lymphoma.

Methods: Eight patients who had histologically proven orbital and adnexal lymphoma between 2011 and 2021 were evaluated retrospectively. The clinical appearance, age, sex, imaging, tumor location, treatment methods, pathologic diagnosis, and systemic features of the patients were obtained from patient files.

Results: The mean age of the patients was 59.1 (range, 42-79) years. Six of the patients were male and two were female. Painless mass and orbital swelling were the most common first signs and symptoms in the patients. The magnetic resonance imaging findings demonstrated unilateral involvement in six patients and bilateral involvement in two patients. Intraorbital location in three patients (behind the orbital septum), lid location in two patients (eyelids in front of the orbital septum), conjunctival involvement in one patient, and lacrimal gland involvement in two patients were detected. All cases were reported as non-Hodgkin B-cell lymphoma [primary extranodal marginal lymphoma of the mucosa-associated lymphoid tissue (n=5), diffuse large B-cell lymphoma (n=2), follicular lymphoma (n=1)].

Conclusion: Orbital lymphomas can be seen more frequently among orbital tumors and clinical findings vary according to the location in the orbit. Ophthalmologists should be attentive to orbital swellings and consider orbital and ocular adnexal lymphomas among differential diagnoses.

Anahtar Kelimeler

lymphoma, orbital diseases, non-Hodgkin lymphoma

Orbital ve Oküler Adneksiyal Lenfomalar: Retrospektif Tek Merkezli Çalışma

Öz

Amaç: Orbital ve adneksiyal lenfomalı hastaların klinik ve histopatolojik özelliklerini değerlendirmek ve sunmak.

Yöntemler: 2011-2021 yılları arasında histolojik olarak orbital ve adneksiyal lenfoma saptanan sekiz hasta retrospektif olarak değerlendirildi. Hastaların klinik görünümü, yaşı, cinsiyeti, görüntülemesi, tümör lokalizasyonu, tedavi yöntemleri, patolojik tanıları ve sistemik özellikleri dosyalardan elde edildi.

Bulgular: Hastaların yaş ortalaması 59.1 (dağılım 42-79) idi. Hastaların 6'sı erkek, 2'si kadındı. Hastalarda ağrısız kitle ve orbital şişlik en sık görülen ilk belirti ve bulguydu. Manyetik rezonans görüntüleme bulgularında 6 hastada unilateral, 2 hastada bilateral tutulum gösterdi. 3 hastada intraorbital yerleşim (orbital septum arkası), 2 hastada göz kapağı yerleşimi (göz kapakları orbital septum önünde), 1 hastada konjonktival, 2 hastada gözyaşı bezi tutulumu tespit edildi. Tüm vakalar patolojik incelemede Non-Hodgkin B hücreli lenfoma [Mukoza ile ilişkili lenfoid dokunun primer ekstranodal marjinal lenfoması (5 hasta), diffüz büyük B hücreli lenfoma (2 hasta), foliküler lenfoma (1 hasta)] olarak rapor edildi.

Sonuç: Orbita tümörleri nadir olmakla birlikte bunlar arasında orbital lenfoma daha sık görülebilmekte ve orbitadaki lokalizasyona göre klinik bulgular değişmektedir. Göz hekimleri orbital şişliklere karşı dikkatli olmalı ve ayırıcı tanılar arasında orbital ve oküler adneksiyal lenfomaları düşünmelidir.

Anahtar Kelimeler

Lenfoma, orbita hastalıkları, Non-Hodgkin lenfoma.

Kaynakça

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