Osteoartrit (OA) şu anda dünya çapında önemli bir ağrı, sakatlık ve sosyoekonomik maliyete neden olan en yaygın kas-iskelet hastalığıdır. Öncelikle dizler ve kalçalar gibi ağırlık taşıyan eklemleri etkiler. Yaşlı erişkinlerde önde gelen sakatlık nedenidir ve ağrıya, işlev kaybına ve yaşam kalitesinin düşmesine neden olur. OA etyopatolojisi, genetik, biyolojik ve biyomekanik bileşenlerle karmaşık ve çok faktörlüdür. OA önceleri ağırlıklı olarak yaşlanmayla ilişkili ve mekanik olarak yönlendirilen basitçe bir "aşınma ve yıpranma" hastalığı olduğu düşünülüyordu. Ancak inflamatuar ve metabolik faktörlerden oluşan çok daha karmaşık bir süreç olduğu artık bilinmektedir. Kalça ve Diz OA'sı ile ilgili çoğu klinik çalışma, esas olarak ağrı ve eklem fonksiyonundaki iyileşmeye odaklanmıştır. Mevcut tedavi yöntemleri OA gidişatını durdurmakta yeterli gözükmemektedir ve tedaviye rağmen fonksiyonel sonuçlar kötü olabilmektedir. Dolayısıyla artık, hastalığı önleme ve erken osteoartrit tedavisine odaklanılmaktadır.
1. Rezuş E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezuş C. From Pathogenesis to Therapy in Knee Osteoarthritis: Bench-to-Bedside. Int J Mol Sci. 2021 Mar 7;22(5):2697. doi: 10.3390/ijms22052697.
2. Abramoff B, Caldera FE. Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Med Clin North Am. 2020 Mar;104(2):293-311. doi: 10.1016/j.mcna.2019.10.007.
4. Aslan A, Kırdemir V, Atay A, Baykal YB, Aytekin Ö, Aydogan FC. [The efficacy of intra-articular injection of hyaluronic acid with supplemental peroral vitamin E following arthroscopic debridement in the treatment of knee osteoarthritis: a prospective, randomized, controlled study]. Turk J Phys Med Re hab 2012;58:199-203. DO I: 10.4274/tftr.36693
5. Aksoy A, Gulcu A, Tuna MM, Aslan A. Radiologically Guided Versus Blinded Intra-articular Injection in Patients With Hip Osteoarthritis: A Retrospective Comparative Study. Clin Med Insights Arthritis Musculoskelet Disord. 2022 Aug 23;15:11795441221118920. doi: 10.1177/11795441221118920.
7. Aslan A, Aydogan NH, Ilhan M, Ozerdemoglu RA, Altuntas I, et al. [The effect of different intraarticular drug applications to the antioxidation system and lipid peroxidation in gonarthrosis]. Eur J Ther. (formerly Gaziantep Med J) 2012;18:1-6 Turkish. DOI: 10.5455/GMJ-30-2011-55.
8. Atik A, Altun E. The Relationship of Inflammatory Indicators and Metabolic Syndrome with Gonarthrotic Cartilage Degeneration: A Novel Glance. Acta Med. Alanya 2021;5(2):144-149 doi:10.30565/medalanya.882840
10. Aslan A. Editöre mektup: Gonartrozda artroskopik debridman ve viskosuplementasyonun yeri [Letter to the editor: Comment on: The use of arthroscopic debridement and viscosupplementation in knee osteoarthritis]. Acta Orthop Traumatol Turc. 2009 May-Jul;43(3):283-4; author reply 284-6. Turkish. doi: 10.3944/AOTT.2009.283.
11. Özkılıç R, Kuru T, İpek S, Keskin E, Işık C, Kaya YE.[ Comparison of the Effects of Intra-articular Hyaluron-ic Acid and Tenoxicam on Pain and Knee Joint Functions in Knee Osteoarthritis.] Acta Med. Alanya 2018;2(3): 149- 158. Turkish doi: 10.30565/medalanya.419286
12. Atay T, Aslan A, Baydar ML, Ceylan B, Baykal B, Kirdemir V. [The efficacy of low- and high-molecular-weight hyaluronic acid applications after arthroscopic debridement in patients with osteoarthritis of the knee]. Acta Orthop Traumatol Turc. 2008 Aug-Oct;42(4):228-33. Turkish. doi: 10.3944/aott.2008.228.
13. Kargın D., Serin E. [Eveluation of Total Knee Arthroplasty Outcomes]. Acta Med. Alanya 2018;2(1):30-34. Turkish. DOI: 10.30565/medalanya.372455
Osteoarthritis (OA) is currently the most common musculoskeletal disease causing significant pain, disability and socioeconomic costs worldwide. It primarily affects weight-bearing joints such as the knees and hips. It is the leading cause of disability in older adults causes pain, loss of function and impaired quality of life. The etiopathology of OA is complex and multifactorial with genetic, biological and biomechanical components. OA was previously thought to be simply a "wear and tear" disease predominantly associated with aging, and mechanically driven. However, it is now known that it is a much more complex process including mechanic, inflammatory and metabolic factors. Most clinical studies of hip and knee OA have focused primarily on improvement in pain and joint function. Current treatment methods do not seem to be sufficient to stop the course of OA, and functional outcomes may be poor in despite of all treatment modalities. The focus is so now on disease prevention and early OA treatment.
1. Rezuş E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezuş C. From Pathogenesis to Therapy in Knee Osteoarthritis: Bench-to-Bedside. Int J Mol Sci. 2021 Mar 7;22(5):2697. doi: 10.3390/ijms22052697.
2. Abramoff B, Caldera FE. Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Med Clin North Am. 2020 Mar;104(2):293-311. doi: 10.1016/j.mcna.2019.10.007.
4. Aslan A, Kırdemir V, Atay A, Baykal YB, Aytekin Ö, Aydogan FC. [The efficacy of intra-articular injection of hyaluronic acid with supplemental peroral vitamin E following arthroscopic debridement in the treatment of knee osteoarthritis: a prospective, randomized, controlled study]. Turk J Phys Med Re hab 2012;58:199-203. DO I: 10.4274/tftr.36693
5. Aksoy A, Gulcu A, Tuna MM, Aslan A. Radiologically Guided Versus Blinded Intra-articular Injection in Patients With Hip Osteoarthritis: A Retrospective Comparative Study. Clin Med Insights Arthritis Musculoskelet Disord. 2022 Aug 23;15:11795441221118920. doi: 10.1177/11795441221118920.
7. Aslan A, Aydogan NH, Ilhan M, Ozerdemoglu RA, Altuntas I, et al. [The effect of different intraarticular drug applications to the antioxidation system and lipid peroxidation in gonarthrosis]. Eur J Ther. (formerly Gaziantep Med J) 2012;18:1-6 Turkish. DOI: 10.5455/GMJ-30-2011-55.
8. Atik A, Altun E. The Relationship of Inflammatory Indicators and Metabolic Syndrome with Gonarthrotic Cartilage Degeneration: A Novel Glance. Acta Med. Alanya 2021;5(2):144-149 doi:10.30565/medalanya.882840
10. Aslan A. Editöre mektup: Gonartrozda artroskopik debridman ve viskosuplementasyonun yeri [Letter to the editor: Comment on: The use of arthroscopic debridement and viscosupplementation in knee osteoarthritis]. Acta Orthop Traumatol Turc. 2009 May-Jul;43(3):283-4; author reply 284-6. Turkish. doi: 10.3944/AOTT.2009.283.
11. Özkılıç R, Kuru T, İpek S, Keskin E, Işık C, Kaya YE.[ Comparison of the Effects of Intra-articular Hyaluron-ic Acid and Tenoxicam on Pain and Knee Joint Functions in Knee Osteoarthritis.] Acta Med. Alanya 2018;2(3): 149- 158. Turkish doi: 10.30565/medalanya.419286
12. Atay T, Aslan A, Baydar ML, Ceylan B, Baykal B, Kirdemir V. [The efficacy of low- and high-molecular-weight hyaluronic acid applications after arthroscopic debridement in patients with osteoarthritis of the knee]. Acta Orthop Traumatol Turc. 2008 Aug-Oct;42(4):228-33. Turkish. doi: 10.3944/aott.2008.228.
13. Kargın D., Serin E. [Eveluation of Total Knee Arthroplasty Outcomes]. Acta Med. Alanya 2018;2(1):30-34. Turkish. DOI: 10.30565/medalanya.372455