Palyatif Radyoterapi Tedavisi Yapılan HIV Negatif Klasik Kaposi Sarkomu Olgusu

Öz

Abstract Palliative Radiotherapy Treatment Case of the HIV-Negative Classic Kaposi's Sarcoma Kaposi's sarcoma (KS) was described in 1872 by Moritz Kaposi as multiple benign pigmentous idiopathic hemorrhagic sarcoma of skin. KS had become widespread in 1980s due to the increasing number of affected patients with acquired immunodeficiency syndrome (AIDS). It has various types such as classical, endemic, and immun deficiency associated types, showing similar immunochemical findings and histopathological appearances. Also, AIDS associated Kaposi\'s sarcoma can be included to this categorization. Radiation therapy often represents the optimal local therapy for palliation of pain, bleeding or oedema in this radioresponsive tumour type. In this report, a case of an 84-year-old male patient with painful and bleeding lesions, diagnosed with classical KS in Ankara University, Department of Dermatology and received radiotherapy with successfull response was presented.

Anahtar Kelimeler

• Kaposi\'s sarcoma; radiotherapy, classical (HIV-negative) Kaposi\'s sarcoma

Palyatif Radyoterapi Tedavisi Yapılan HIV Negatif Klasik Kaposi Sarkomu Olgusu

Öz

Kaposi sarkomu (KS) 1827 yılında Moritz Kaposi tarafından “derinin idyopatik, multipl, pigmente hemorajik sarkomu” adıyla tanımlanmıştır. Kaposi sarkomu 1980\'li yıllarda Akkiz İmmun Yetmezlik Sendromu\'nun (AIDS) gündeme gelmesi ile yaygınlaşmıştır. Benzer immunkimyasal bulgular ve histopatolojik görünüm taşıyan klasik, endemik, immun yetmezlik ile birlikte görülen ve AIDS ile ilişkili tipleri mevcuttur. Radyasyon tedavisine oldukça duyarlı olduğu bilinen kaposi sarkomlarında ağrı, kanama ve ödem bulgularının palyatif tedavisinde radyoterapi uygulanmaktadır. Bu yazıda Ankara Üniversitesi Dermatoloji bölümünde yapılan biopsi sonucunda klasik tip kaposi sarkomu tanısı almış olan, ağrılı, kanamalı lezyonları olan ve tedaviye iyi yanıt veren 84 yaşındaki erkek olgu sunulmuştur.

Anahtar Kelimeler

• Kaposi sarkomu, radyoterapi, HIV-negatif klasik tip Kaposi sarkomu

Kaynakça

1. Kaposi M. ldiopathisches multiples pigmentsarcom der ham. Arc Dermatol S_vphı'lol 1982;4:265-3. Yalman re ark.
2. Weissmann A, Linn S, Wellfriend S, Friedman-Birnbaum R. Epidemiological study of classic Kaposi‘s Sarcoma: a retrospective review of 125 cases from Northern Israel. J Eur Acad Dermatol Venerea 2000;14(2):91-5.
3. Di Lorenzo G. Update on classic Kaposi Sarcoma therapy: a new look at an old disease. Crit Ret-’ 0am Hematol 2008:68(3):242-9.
4. Safari B. AIDS-related Kaposi’s sarcoma: therapy options for today and tomorrow. Oncology 1996; 10:1-38.
5. Cooper JS. Steinfeld AD. Lerch IA. Intentions and outcomes in the rarliotherapeutic management of epidemic Kaposi’s sarcoma. Int J Radial Cnm Phys 1991208): 419-22.
6. Gressen EL. Roscnstrock JG. Xie Y. Corn BW. Palliative Treatment of epidemic Kaposi Sarcoma of the feet. Am J Clin Oar-01 l999:22(3):286-90.
7. Chang LF. Reddy S. Shidnia H. Coparison of radiation therapy of classic and epidemic Kaposi’s sarcoma. Am .] Clin Oneal 1992:15(3):200—6.
8. Lo TC. Salzman FA. Smedal M]. Wright KA. Radiotherapy for Kaposi’s sarcoma. Cancer l980:45(4):684-7.

9. Holecek MJ. Harwood A. Radiotherapy of Kaposi’s sarcoma. Cancer 1978;41(5):1733-8.
10. Harrison M. Harrington K], Tomlinson DR. Stewart JS. 14. de Wit R. Smit WG, Veenkof KH, Bakker PJ. Oldenburger F, Gonzalez DG. Paliative radiation therapy for AIDS- associated Kaposi's sarcoma by using single fraction of 800cGy. Radr'mher Onca l990;l9(2): 131-6.
11. Yıldız F, Genc M, Akyürek S. Cengiz M. Ozyar E. Selek U. Atahan IL. Radiotherapy in the management of Kaposi‘s sarcoma: Comparison of 8 Gy versus 6 Gy. J Nar Med Assoc 2006;98(7):1 136-9.