Isı Şoku Proteinleri: Mevcut Durum ve Gelecekteki Yönelimler

Yıl 2025, Cilt: 15 Sayı: 2 , 311 - 320 , 25.12.2025

Kadriye Yılmaz , Ebru Karadağ Sarı

https://doi.org/10.53518/mjavl.1737446

https://izlik.org/JA58YJ57LG

Öz

Canlılarda yaşamın sürekliliği ve hücresel olaylar, hücre içinde var olan mekanizmalar ile bu mekanizmalarda görev yapan moleküller aracılığı ile sağlanmaktadır. Organizmanın varlığını devam ettirerek çevreyle uyum içerisinde olmasının temel nedeni hücresel olaylarda rol alan moleküllerin kendi içlerinde etkileşimde olmasından kaynaklanmaktadır. Aminoasitlerin sayı, tür ve belirli diziliş şeklinde bir araya gelerek düz karakteristik bir zincirde peptid bağları ile birbirine bağlanmasıyla oluşan polipeptitlere protein adı verilmektedir. Proteinler ribozomda sentezlenir ve bu sentez sonucu polipeptitler meydana gelmektedir. Meydana gelen bu polipeptitler doğru biçimde katlanarak 3 boyutlu (3B) yapıya dönüşerek işlev kazanmaktadır Proteinler hücre olaylarındaki en önemli makromoleküllerdir Organizmada bulunan proteinlerin hatasız bir şekilde katlanması ve 3B yapısına ulaşması için yardımcı olan proteinlere “şaperon” adı verilmektedir. Birçok proteinin şaperon aktivitesine sahip olduğu ve ayrıca birçok şaperonun da stres proteini olarak görev yaptığı ve bunların en önemlisinin ısı stresine bağlı olarak artış gösteren ısı şok proteinleri (HSP) olduğu bildirilmiştir Bu derlememizde moleküler şaperonlar ve HSP hakkında bilgi verilmektedir. Ayrıca HSP’lerin yapısı ve üyeleri ayrı başlıklar altında incelenerek üyelerin özelliklerinden de bahsedilmektedir. HSP’nin görevlerinden ve Isı şok faktörlerinin özelliklerine de değinilmektedir.

Anahtar Kelimeler

Isı şoku etkileri , HSP (Isı şoku proteinleri) , Moleküler şaperonlar

Etik Beyan

“Isı Şoku Proteinleri: Mevcut Durum ve Gelecekteki Yönelimler” başlıklı çalışmanın yazım sürecinde bilimsel kurallara, etik ve alıntı kurallarına uyulmuş; toplanan veriler üzerinde herhangi bir tahrifat yapılmamış ve bu çalışma herhangi başka bir akademik yayın ortamına değerlendirme için gönderilmemiştir. Bu araştırma doküman analizi ve betimsel incelemeye dayalı olarak yapıldığından etik kurul kararı zorunluluğu bulunmamaktadır.

Heat Shock Proteins: Current Status And Future Directions

https://izlik.org/JA58YJ57LG

Öz

The continuity of life and cellular processes in living organisms is facilitated by cellular mechanisms and the molecules that operate within these systems. The primary reason for an organism's continued existence and its harmony with the environment is the interaction of molecules involved in cellular processes. Proteins, which are polypeptides formed by the specific sequence and combination of amino acids linked by peptide bonds, are synthesized in the ribosome. These polypeptides undergo proper folding to acquire three-dimensional (3D) structures and functional capabilities. Proteins are crucial macromolecules in cellular processes. Proteins that assist other proteins in achieving flawless folding and attaining their 3D structure are termed "chaperones." It has been documented that numerous proteins exhibit chaperone activity and that many chaperones also function as stress proteins, with heat shock proteins (HSPs) being particularly significant due to their increase under heat stress. This review provides information on molecular chaperones and HSPs. Additionally, the structure and members of HSPs are examined under distinct headings, and the characteristics of these members are discussed. The functions of heat shock proteins and the attributes of heat shock factors are also addressed.

Anahtar Kelimeler

Heat shock effects , HSP , Molecular chaperones

Etik Beyan

The writing process of the study titled “ Heat Shock Proteins: Current Status And Future Directions” complied with scientific rules, ethical and citation rules; no alterations were made to the collected data, and this study has not been submitted for evaluation to any other academic publication medium. Since this research is based on document analysis and descriptive examination, there is no requirement for an ethics committee decision.

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