Antipsikotikler ve Antidepresanlar Aort Diseksiyonlarının Oluşumunu veya Kronikleşmesini Etkileyebilir mi?

Yıl 2021, , 497 - 500, 25.12.2021

Burak Can Depboylu , Buğra Harmandar , Kadir Arslan Serkan Yazman

https://doi.org/10.29058/mjwbs.894748

Öz

Akut Stanford tip-A aort diseksiyonları(STAAD), aort rüptürü, ciddi aort kapak yetmezliği, perikardiyal
tamponad ve serebral ve/veya koroner malperfüzyon risklerini ortadan kaldırmak için acil cerrahi
gerektiren, hayatı tehdit edici hastalıklardır. Sadece küçük bir hasta alt grubu fark edilmez ve belirsiz
mekanizma ile kronikleşir. Bu hastalar genellikle geç semptomlar yüzünden veya tesadüfen teşhis edilir.
Kardiyopulmoner bypass ve bazen derin hipotermi ve sikülatuvar arrest gerektiren cerrahi teknikler,
önemli mortalite ve komplikasyonları olan ilk basamak tedavilerdir. Burada, antipsikotik ve antidepresan
tedavi alan ve total aortik ark replasmanı ile başarıyla onarılan tanısı tesadüfen konulmuş kronik STAAD
hastası sunulmuştur

Anahtar Kelimeler

Kronik aort diseksiyonu, Kan basıncı, Antipsikotikler, Antidepresanlar, Cerrahi

Can Antipsychotics and Antidepressants Affect the Formation or Chronicization of Aortic Dissections?

Öz

Acute Stanford type-A aortic dissections (STAAD) are life-threatening diseases which require
emergency surgery to eliminate risks of aortic rupture, severe aortic valve insufficiency, pericardial
tamponade and cerebral and/or coronary malperfusion. Only a small subset of patients go unnoticed
and become chronic with unclear mechanism. These patients are usually diagnosed thru late symptoms
or incidentally. Surgical techniques requiring cardiopulmonary bypass and sometimes deep hypothermia
and circulatory arrest are first-line treatments with considerable mortality and complications. Herein,
an incidentally diagnosed chronic STAAD patient who was receiving antipsychotic and antidepressant
treatment and successfully repaired with total aortic arch replacement was presented.

Anahtar Kelimeler

Chronic aortic dissection, Blood pressure, Antipsychotics, Antidepressants, Surgery

Kaynakça

• Reference 1. Kim WK, Park SJ, Kim HJ, Kim HJ, Choo SJ, Kim JB. The fate of unrepaired chronic type A aortic dissection. J Thorac Cardiovasc Surg. 2019;158:996-1004.e3.
• Reference 2. Shin SW, Lee JS, Abdi S, Lee SJ, Kim KH. Antipsychotics for patients with pain. Korean J Pain 2019;32:3-11.
• Reference 3. Alves BB, Oliviera GDP, Neto MGM, Fiorilli RB, Cestario EDES. Use of atypical antipsychotics and risk of hypertension: a case report and review literature. SAGE Open Med Case Rep.2019;7:1-6.
• Reference 4. Falissard B, Mauri M, Shaw K, Wetterling T, Doble A, Giudicelli A, et al. The METEOR study: frequency of metabolic disorders in patients with schizophrenia. Focus on first and second generation and level of risk of antipsychotic drugs. Int Clin Psychopharmacol. 2011;26:291-302.
• Reference 5. Dania H, Barliana MI, Perwitasari DA, Abdulah R. Effect of Atypical Antipsychotic on Blood Pressure in Inpatients with Schizophrenia of Prof. Dr. Soerojo Mental Health Hospital Magelang. J Pharm Bioallied Sci. 2019;11(Suppl 4):580-6.
• Reference 6. Peterss S, Mansour AM, Ross JA, Vaitkeviciute I, Charilaou P, Dumfarth J, et al. Changing pathology of the thoracic aorta from acute to chronic dissection: Literature review and insights. J Am Coll Cardiol 2016;68:1054-65.