A manic episode induced by herbal preparate golden berry (cape gooseberry) (Physalis peruviana L.)

Öz

Herbal preparationsare widely used especially in treatment of cancer, losing weight, analgesia, or for other health problems in folk medicine. In psychiatric disorders they are used especially for insomnia, anxiety, depression, and sexual disorders. The research investigating the efficacy and side effects of these preparations has arrived atdifferent conclusions, also pharmacological mechanisms of these agents and their drug interactions are not very well unknown. Here we report a patient, who applied to our emergency service for concurrent manic symptoms with history of using “golden berry” to lose weight. The patient had a history of depressive episode five years ago, but no manic or hypomanic episodes in the past.

Anahtar Kelimeler

• -

Altın çilek (Physalis peruviana L.) bitkisel preparatının indüklediği manik atak olgusu

Öz

Bitkisel preparatların farklı kültürlerde başta kanser tedavisi, kilo verme, ağrı kesici olmak üzere birçok alanda yaygın kullanımları mevcuttur. Psikiyatride ise özellikle kaygı giderici, uykusuzluk, depresyon ve cinsel işlev bozukluklarını tedavisinde kullanılmaktadır. Bu ajanların gerek etki mekanizmaları gerekse de yan etki açısından yapılan çalışmalarda farklı sonuçlar bulunmuştur ancak herbir molekülün içeriği, farmakolojik etki mekanizması tam olarak bilinmemektedir. Olgumuz daha öncesinde bir kere depresif dönem geçiren ve takip eden süreçte herhangi bir psikiyatrik yakınması yokken zayıflamak maksatlı altın çilek preparatını kullandıktan sonra manik hecme geçiren bir olgudur. Aşağıda bu hastanın sunumu ve tedavi yanıtı ele alınmıştır.

Anahtar Kelimeler

• bitkisel preparatlar, geleneksel tıp, mizaç bozuklukları, altın çilek (Physalis peruviana)

Kaynakça

1. Emmanuel NP, Jones C, Lydiard RB. Use of herbal products and symptom of bipolar disorder. Am J Psychiatry. 1998;155:1627.
2. Çelik S, Konkan R, Erkmen H, Tabo H, Erkıran M. Bitkisel ilaçlar ve psikiyatride kullanımı. Düşünen Adam. 2007;20:186-95.
3. Katz JL. A psychotic manic state induced by an herbal preparation. Psychosomatics. 2000;41:73-74.
4. Walton R, Manos GH. Psychosis related to ephedra-containing herbal supplement use, Southern medical journal. 2003;96:718-20.
5. Zhang LD, Zhang YL, Xu SH, Zhou G, Jin S B. Traditional Chinese medicine typing of affective disorders and treatment. Am J Chin Med. 1994;22:321-7.
6. Andreescu C, Mulsant BH, Emanuel JE. Complementary and alternative medicine in the treatment of bipolar disorder-a review of the evidence. J Affect Disord. 2008; 110:16-26.
7. Maremmani I, Perugi G, Rovai L, Maremmani AG, Pacini M, Canonico PL, Carbonato P, Mencacci C, Muscettola G, Pani L, Torta R, Vampini C, Akiskal HS. Are “social drugs” (tobacco, coffee and chocolate) related to the bipolar spectrum? J Affect Disord. 2011;133:227-33.
8. Boerth JM, Caley C. Possible case of mania associated with ma-huang. Pharmacotherapy. 2003;23:380-3.

9. Fahmi M, Huang C, Schweitzer I. A case of mania induced by hypericum. World J Biol Psychiatry. 2002;3:58-9.
10. Wikipedia. The free encyclopedia. http://en.wikipedia.org/wiki/ Physalis_peruviana 2011.
11. Wu SJ, Ng LT, Huang YM, Lin DL, Wang SS, Huang SN,Lin CC. Antioxidant activities of Physalis peruviana. Biol Pharm Bull. 2005;28:963-6.
12. Ramadan, M. F. Bioactive phytochemicals, nutritional value, and functional properties of Cape gooseberry (Physalis peruviana): An overview. Food Research International. 2011;44:1830-6.
13. Yen CY, Chiu CC, Chang FR, Chen JY, Hwang CC, Hseu YC, Yang HL, Lee AY, Tsai MT, Guo ZL, Cheng YS, Liu YC, Lan YH, Chang YC, Ko YC, Chang HW, Wu YC. 4 beta-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest. BMC Cancer. 2010;10:46.
14. Bahadır Bakım, Gökay Alpak, Hakan Serdar Şengül, Nilay Kahraman, Onur Tankaya, Kayıhan Oğuz Karamustafalıoğlu. Acute secondary mania due to amoxicillin use in a patient with family history of mood disorders. JMOOD. 2011;1:72-4.
15. Tsuboi H, Tatsumi A, Yamamoto K, Kobayashi F, Shimoi K, Kinae N. Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants. J Affect Disord. 2006;91:63-70