Türkiye-Erzurum Orijinli Micromeria fruticosa Yaprak Etil Asetat Ekstresinin Fitokimyasal Profili

Yıl 2025, Cilt: 7 Sayı: 3, 488 - 496, 31.12.2025

Handan Uğuz Bayrakçeken , Şeyma Bulut , Acelya Kardelen Karadag

https://doi.org/10.47112/neufmbd.2026.108

Öz

Bitkiler, eski zamanlardan beri beslenmenin yanı sıra tıbbi ve geleneksel amaçlarla kullanılmaktadır. Bitkilerin yapısında yer alan çeşitli biyoaktif bileşikler ve ikincil metabolitlerden, ilaç ve biyoteknoloji endüstrilerinde çeşitli amaçlarla etkin bir şekilde yararlanılmaktadır. Türkiye bitki çeşitliliği bakımından oldukça zengin bir coğrafyaya sahiptir ve bu nedenle ilaç etken maddesi olarak kullanılabilecek çok sayıda bitki türü mevcuttur. Bu bitkilerden biri olan Micromeria fruticosa, Lamiaceae ailesine ait çok yıllık aromatik bir çalıdır. Bitki, geleneksel tıpta birçok rahatsızlığın tedavisinde semptomları hafifletmek için yaygın olarak mevcılmaktadır. Biyotik ve abiyotik koşullara göre bitkinin içerdiği bileşenler ve oranları büyük ölçüde değişebilmektedir. Bu nedenle, bu çalışma Türkiye'nin Erzurum ili Tortum ilçesinde yetiştiği bilinen M. fruticosa bitkisinin yapraklarından elde edilen etil asetat ekstraktındaki biyoaktif bileşiklerin belirlenmesi amacıyla gerçekleştirilmiştir. Analizin gerçekleştirilmesi için ilk adım olarak, M. fruticosa yaprak etil asetat (EA-MFL) ekstraksiyonu maserasyon yöntemi kullanılarak elde edildi. M. fruticosa bitkisinin kimyasal bileşenlerinin belirlenmesi için Gaz Kromatografisi Kütle Spektroskopisi (GC-MS) yöntemi kullanılmış ve yaprakta 7 bileşik tanımlanmıştır. Major bileşenler heptacosane (%73,939) ve piperitenone (%12,658) olup; tespit edilen diğer bileşenler sırasıyla ethyl iso-allocolate (%5,722), 3-ethyl-5- (2-ethylbutyl) octadecane (%3,861), pulegone (%2,590), toluene (%0,898) ve o-acetylserine (0,332) olarak belirlenmiştir.

Anahtar Kelimeler

Micromeria fruticosa , Gaz Kromatografisi -Kütle Spektroskopisi , Etil asetat ekstraksiyonu , Piperitenone

Phytochemical Profile of Micromeria fruticosa Leaf Ethyl Acetate Extract from Erzurum, Türkiye

Öz

The utilization of plants for nutritional, medicinal, and traditional purposes dates back to ancient times. Various bioactive compounds and secondary metabolites found in plants are effectively utilized for various purposes in the pharmaceutical and biotechnology industries. Türkiye’s extensive plant biodiversity has led to the identification of numerous plant species as potential active pharmaceutical ingredients. One of these plants, Micromeria fruticosa, is a perennial aromatic shrub belonging to the Lamiaceae family. The plant is widely used in traditional medicine to alleviate symptoms associated with the treatment of numerous ailments. The components and proportions contained in the plant can vary greatly depending on biotic and abiotic conditions. Therefore, this study was conducted to determine the bioactive compounds present in the ethyl acetate extract obtained from the leaves of M. fruticosa, a plant species known to be native to the Tortum district of Erzurum province, Türkiye. The initial phase of analysis involved the extraction of M. fruticosa leaf ethyl acetate (EA-MFL) through the maceration method. The chemical components of M. fruticosa were determined by Gas Chromatography Mass Spectrometry (GC-MS). The analysis revealed the presence of seven compounds in the leaf. The major components were identified as heptacosane (73.939%) and piperitenone (12.658%). Other detected components included ethyl iso-allocolate (5.722%), 3-ethyl-5-(2-ethylbutyl) octadecane (3.861%), pulegone (2.590%), toluene (0.898%), and o-acetylserine (0.332%).

Anahtar Kelimeler

Micromeria fruticosa , Gas Chromatography Mass Spectroscopy , Ethyl acetate extraction , Piperitenone

Etik Beyan

The present study is an original research article designed and produced by the authors.

Destekleyen Kurum

This research was not supported by any public, commercial, or non-profit organization.

Teşekkür

We would like to thank Prof. Dr. Bilal Yılmaz, Faculty Member of Atatürk University Faculty of Pharmacy, for her support and contributions to the GC-MS analysis of the study.

Kaynakça

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