Maternal and neonatal outcomes related to iron deficiency anemia and serum ferritin status: A multicenter prospective study from Eastern Marmara, Turkey

Abstract

Background: Iron deficiency is the most common nutritional deficit in the world. More than 50% of anemia in pregnancy results from iron deficiency and it is suggested that it may be associated with negative pregnancy outcomes.

Aim: The aim of this study was to evaluate the incidence of irony deficiency anemia in pregnancy in the East Marmara region of Turkey in order to determine its prevalence in the country along with the effects and associations of iron supplementation or iron status on maternal and neonatal outcomes.

Study Design: The study was designed as a prospective, longitudinal qualitative study.

Method: This study was conducted in six centers in three provinces of the East Marmara region(Turkey) and included a total of 1102 pregnant women. Blood samples were collected for hematological status and serum ferritin levels during pregnancy, and the adverse maternal and perinatal outcomes were determined.

Results: The rate of anemia among the women included in the study was 19.8%, with 44% of them receiving iron supplementation. The maternal age was lower in the anemic group(26.5 vs. 27.7, p = 0.01). Selective iron use was more frequent in the anemic group, while routine iron use was more frequent in the non-anemic group(47.1% vs. 29.3%; p = 0.01).

Conclusions: Iron deficiency anemia is a frequent problem in pregnancy. However, many anemic pregnant women do not receive iron therapy. Iron supplementation may have positive effects on some maternal and perinatal outcomes. In order to combat iron deficiency anemia in pregnancy, widespread use of iron supplements should be established.

Keywords

• Anemia,ferritin,iron deficiency,iron supplementation,pregnancy

Demir Eksikliği Anemisi ve Serum Ferritin Düzeyi ile İlgili Maternal ve Neonatal Sonuçlar: Doğu Marmara Bölgesine Ait Çok Merkezli Bir Prospektif Çalışma, Türkiye

Öz

Amaç: Bu çalışmanın amacı, demir takviyesi ve demir durumunun maternal ve neonatal etkileri ile birlikte Türkiye'nin Doğu Marmara bölgesinde gebelikte görülen demir eksikliği anemisi insidansını değerlendirmektir.

Yöntem: Bu çalışma Doğu Marmara Bölgesi'nin (Türkiye) üç ilinde altı merkezde gerçekleştirilmiş ve toplam 1102 gebeyi kapsamıştır. Gebelik sırasında hematolojik durum ve serum ferritin düzeyleri için kan örnekleri toplandı ve olumsuz maternal ve perinatal sonuçlar belirlendi.

Bulgular: Çalışmaya dahil edilen kadınlarda anemi oranı % 19.8 idi ve bunların % 44'ü demir desteği alıyordu. Maternal yaş anemik grupta daha düşüktü (26.5'e karşı 27.7, p = 0.01). Anemik grupta selektif demir kullanımı daha sık görülürken, anemik olmayan grupta rutin demir kullanımı daha sık görüldü (% 47.1'e karşılık% 29.3; p = 0.01).

Sonuçlar: Demir eksikliği anemisi gebelikte sık görülen bir problemdir. Bununla birlikte, birçok anemik gebeye demir tedavisi verilmez. Demir takviyesi, bazı maternal ve perinatal sonuçlar üzerinde olumlu etkileri olabilir. Gebelikte demir eksikliği anemisiyle mücadele etmek için demir takviyelerinin yaygın kullanımı sağlanmalıdır.

Anahtar Kelimeler

• Anemi,demir eksikliği,demir desteği,gebelik

Kaynakça

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