Akciğerin dev hücreli tümörü: cerrahi tedavi yönetimi

Yıl 2019, , 125 - 130, 01.06.2019

Funda İncekara , Ebru Sayılır Güven Şevki Mustafa Demiröz , Merve Şengül İnan Koray Aydoğdu , Funda Demirağ Selim Şakir Erkmen Gülhan Sadi Kaya , Göktürk Fındık

https://doi.org/10.21601/ortadogutipdergisi.440816

Öz

Amaç: Pulmoner dev hücreli karsinom (PDHK) küçük
hücreli dışı akciğer kanserinin bir histolojik tipidir ve akciğer sarkomatoid karsinomunun
beş subtipinden biri olarak sınıflandırılır. Pür PDHK çok nadirdir.

 Gereç ve Yöntem: Kliniğimizde PDHK nedeni ile tedavi gören 7 hastayla
ilgili tecrübelerimizi sunduk (6 erkek ve 1 kadın, yaş aralığı 46-63 yıl). En sık
görülen semptomlar öksürük ve hemoptizi idi. Üst lobektomi (n=7) ve ek olarak mediastinal
lenfadenektomi bütün hastalara uygulandı.

Bulgular: Kesin histolojik inceleme ile tüm hastalarda PDHK tanısı doğrulandı.
Herhangi bir perioperatif mortalite görülmemesine rağmen bir olguda ameliyat sonrası
komplikasyon gelişti; erken perioperatif dönemde hemoraji ve operasyondan iki ay
sonra bronşiyal fistül gelişti. Hastaların ortalama sağkalımı 28,8 ay (38 gün-116
ay) olarak bulundu.

Sonuç: PDHK için asıl tedavi komplet cerrahi rezeksiyondur. Komplet cerrahi
rezeksiyonun erken evre PDHK için yararlı bir tedavi tercihi olduğu ve sağkalıma
katkı sağladığı bulunmuştur.

Anahtar Kelimeler

Kemoterapi, dev hücreli karsinom, radyoterapi, cerrahi, Dünya Sağlık Örgütü

Giant Cell Carcinoma of the Lung: Management of Surgical Treatment

Öz

Objectives: Pulmonary giant cell carcinoma (PGCC) is a
histological type of nonsmall cell lung cancer and classified as one of the five
subtypes of sarcomatoid carcinoma of the lung. Pure PGCC is very rare.

Material and Method: We represent our experience in the management
of 7 patients (6 males and 1 female, with a range of 44-63 yr) with PGCC. The most
representing symptoms were cough and hemoptysis. Upper lobectomy (n=7) and additionally
mediastinal lymphadenectomy were performed in all patients.

Results: Definitive histological examination confirmed
the diagnosis of PGCC in all cases. Even though there was no perioperative mortality,
postoperative complications developed in a case were hemorrhage in the early perioperative
period and bronchus fistula after two months from the operation. The mean survival
of the patients was estimated as 28.8 months (38 days - 116 months).

Conclusion: The main treatment for PGCC is the complete
surgical resection. Complete surgical resection was found to be usefull as a treatment
of choice of PGCC in the early stage and contributed to survival.

Anahtar Kelimeler

Chemotherapy, giant cell carcinoma, radiotherapy, surgery, World Health Organization

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