Hipotiroid hastalarda plazma visfatin konsantrasyonlarının tiroid otoimmünitesi ve ateroskleroz ile ilişkisi

Yıl 2018, Cilt: 10 Sayı: 4, 498 - 505, 01.12.2018

Bekir Ucan , M. Nur Kebapci Sema Uslu Mehmet Kara Nevbahar Akcar Degirmenci Setenay Oner

https://doi.org/10.21601/ortadogutipdergisi.364345

Öz

Amaç: Visfatin/pre-B cell enhancement factor; insülin direnci, diyabet,
dislipidemi, inflamasyon, otoimmun hastalıklar ve ateroskleroz
patogeneziyle ilişkili adipoz dokudan salınan TNF-alfa ve IL-6 gibi inflamatuar
sitokinlerin yapımını uyarır. Bu çalışmada amacımız otoimmün hipotiroidizmli
hastalarda plazma visfatin düzeyi ve bunun tiroid otoimmünitesi ve ateroskleroz
ile ilişkisini değerlendirmektir.

Gereç ve Yöntem: Çalışmamıza 35 yeni tanı almış Hashimoto hipotiroidili olgu (32 kadın/3 erkek,
ort. yaş 43.8±9.6) ve 18 sağlıklı kontrol (17 kadın/1 erkek, ort. yaş 43.3±5.2)
dahil edildi. Tiroid hormon replasmanı öncesi ve sonrası antropometrik
ölçümler, karotid intima-media kalınlığı (KİMK), serum anti-Tg, anti-TPO,
hsCRP, homosistein, lipo(a), ApoA, ApoB1, β-2 mikroglobulin, insulin, glukoz,
visfatin, IL6, TNF-α, okside-LDL, lenfosit subgrupları ve lipid profile
ölçümleri yapıldı. Serum visfatin konsantrasyonları ELİSA yöntemiyle çalışıldı.

Bulgular: Serum visfatin konsantrasyonları otoimmün hipotiroidizm grubu ile
kontrol grubu arasında benzerdi (6.29 ± 1.63 ng/ml to 6.36 ± 1.51 ng/ml,
p>0.05), tiroid otoimmünitesi ve ateroskleroz belirteçleriyle korelasyonu
saptanmadı. Tedavi öncesi ve sonrası hipotiroidi hastalarının plazma visfatin,
okside LDL, IL-6 ve TNF-α konsantrasyonları ile sağlıklı kontrol grubu
arasında istatiksel farklılık görülmedi. Sistolik ve diyastolik kan
basıncı, HOMA-IR, trigliserid, Apo B and ApoB/ApoA, homosistein, β-2
mikroglobulin, KİMK gibi kardiyovasküler risk faktörleri hasta grubunda yüksek
olarak bulundu. Okside-LDL, kolesterol, homosistein ve proteinuria
konsantrasyonları anti-Tg ile pozitif korele idi.

Sonuç: Serum visfatin konsantrasyonları ile tiroid otoimmünitesi ve
ateroskleroz arasında ilişki bulunmadı.

Anahtar Kelimeler

Visfatin, otoimmüne hipotiroidi, ateroskleroz

Plasma visfatin concentrations in hypothyroid patients and its relationship with thyroid autoimmunity and atherosclerosis

Öz

Aim: Visfatin/pre-B cell enhancement factor stimulates the
production of inflammatory cytokines released from adipose tissue such as TNF-α
and IL-6, which are shown to be related to the pathogenesis of insulin
resistance, diabetes, dyslipidemia, inflammation, autoimmune diseases, and
atherosclerosis. Our aim was to evaluate plasma visfatin concentrations in
patients with autoimmune hypothyroidism and its relationship with thyroid
autoimmunity and atherosclerosis.

Material and Method: Thirty-five patients with newly diagnosed Hashimoto’s thyroiditis
(32 women/3 men, mean age 43.8±9.6 years) and 18 healthy controls (17 women/1
men, mean age 43.3±5.2 years) were enrolled in the study. Anthropometric
measurements, carotid intima-media thickness (CIMT), serum anti-Tg, anti-TPO,
hsCRP, homocysteine, lipo(a), ApoA, ApoB1, β-2 microglobulin, insulin, glucose,
visfatin, IL6, TNF-α, oxidized-LDL concentrations, lymphocyte subgroups and
lipid profile were investigated both before and after thyroid hormone
replacement therapy. Serum visfatin concentrations were determined by
enzyme-linked immunosorbent assay (ELISA).

Results: Mean serum visfatin concentrations were similar between autoimmune
hypothyroidism group and control group (6.29 ± 1.63 ng/ml to 6.36 ± 1.51 ng/ml,
p>0.05) and it was not correlated with thyroid autoimmunity and
atherosclerosis markers.  Plasma
visfatin, oxidized LDL, IL-6, and TNF-α concentrations did not differ
statistically between the control group and hypothyroid patients both before
and after the therapy. The cardiovascular risk factors for systolic and
diastolic blood pressure, HOMA-IR index, triglyceride, Apo B and ApoB/ApoA,
homocysteine, β-2 microglobulin, and CIMT were found to be elevated in
patients. Ox-LDL, cholesterol, homocysteine, and proteinuria concentrations
were positively correlated with anti-Tg concentrations.

Conclusion: Serum visfatin concentrations were not associated with thyroid
autoimmunity and atherosclerosis. 

Anahtar Kelimeler

Visfatin, autoimmune hypothyroidism, atherosclerosis

Kaynakça

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