Akciğer Fibrozisinin Moleküler Mekanizmaları

Öz

Akciğer fibrozisi oldukça heterojen ve yaşamı tehdit eden bir hastalıktır. Akciğer fibrozisinin moleküler patogenezi üzerine yapılan çalışmalar daha çok hücre dışı matriks ve kollajen artışını düzenleyen mekanizmalara odaklanmıştır. Bu çalışmalar var olsa da, birçok farklı yeni çalışma da yapılmaktadır. Bu çalışmalar daha çok fibroblast aktivasyonunu ve farklılaşmasını düzenleyen mekanizmalara, fibrozisin nasıl başladığına ve nasıl ilerlediğine odaklanmaktadır. Bu derlemede özellikle akciğer fibrozisinin moleküler mekanizmaları üzerinde durulmuş ve mekanizmaları incelenmiştir.

Anahtar Kelimeler

• Lung fibrosis
• Molecular mechanism
• Fibrosis

Lung fibrosis molecular mechanisms

Öz

Lung fibrosis is a highly heterogeneous and life-threatening disease in patients. Studies on the molecular pathogenesis of lung fibrosis have more often focused on the mechanisms regulating the increase of extracellular matrix and collagen. Although these studies have been conducted in this way, many different new studies are also being conducted. These studies have focused more on the mechanisms regulating fibroblast activation and differentiation, how fibrosis starts and how it progresses. In this review, especially the molecular mechanisms of lung fibrosis are emphasized and examined.

Anahtar Kelimeler

• Lung Fibrosis
• Molecular Mechanism
• Fibrosis

Kaynakça

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