Alzheimer Hastalığında Demirin Rolü

Öz

Alzheimer hastalığı (AH), demans tablosunun en sık nedeni (%60-80) olan kronik nörodejeneratif bir hastalıktır. Her yıl tüm dünyada 4.6 milyon yeni AH olgusu geliştiği tahmin edilmektedir. Hastalığın görülme riski yaşa bağlı olarak logaritmik biçimde artar. Yaşı 60-65 arasında olan popülasyonda görülme sıklığı yaklaşık olarak %0.1 iken 85 yaşın üzerinde görülme sıklığı %47’ye kadar çıkar. Tanı konulmasında özel bir belirteç olmaması, bilim adamlarını farklı tanı yolları aramaya itmiştir. Bu nedenle yapılan incelemelerde serum demiri yüksek ve transferrin saturasyonu düşük erişkinlerde nörolojik demansiyel hastalıkların başlayabileceği ortalama 6 ay öncesinden öngörülebilmektedir. Serum demiri yüksekliği beyin dokusunda da demir yüksekliğine yol açabilmektedir. Bu süreç, AH’de erken tanı açısından faydalı olacaktır.

Anahtar Kelimeler

• Alzheimer hastalığı

The Role of Iron in Alzheimer’s Disease

Öz

Alzheimer’s disease is a chronical neurodegenerative disease and it is the most commanly seen (%60-80) reason of dementia.  It is predicted that every year 4.6 million new cases occur around the world. The risk increases logarithmically depending on age. The incidence is %0.1 between ages 60-65  while it is %47 over age 85. Scientists are researching on  different diagnostic methods since there isn’t a certain indicator for diagnosis. Research showed that blood iron levels increasing and transferrin saturation starts decreasing 6 months before the neurogical demential diseases occur. High iron levels in blood serum causes high iron levels in the brain tissue. This process will be useful for early diagnosis of AD.

Anahtar Kelimeler

• Alzheimer Disease and blood iron levels

Kaynakça

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