The Relationship Between Neutrophil/Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) with Microalbuminuria in Participants with Different Glucose Tolerances

Öz

Neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of subclinical inflammation for chronic diseases. Mean platelet volume (MPV) is a platelet function index. This study aimed to evaluate the relationship of NLR and MPV with microalbuminuria in participants with different glucose tolerances. 951 patients (male/female=302/649) were divided into five groups according to their oral glucose tolerance test (OGTT) results: group 1=normal glucose tolerance (NGT), group 2=impaired fasting glucose (IFG), group 3=isolated impaired glucose tolerance (IGT), group 4=both IFG and IGT, and group 5=type 2 diabetes mellitus (DM). Additionally, patients were divided into three groups according to their glycated hemoglobin (HbA1c) results: group 1=NGT, group 2=prediabetes, and group 3=type 2 DM. Outcomes were compared between groups. According to the OGTT, HbA1c, and OGTT+HbA1c criteria, there was a significantly positive correlation of microalbuminuria with MPV and NLR in all DM patients (p<0.001). Additionally, according to the OGTT, HbA1c, and OGTT+HbA1c criteria, there was a significantly positive correlation between MPV and microalbuminuria in all NGT patients (p<0.001). According to the OGTT and OGTT+HbA1c criteria, there was no significant correlation between NLR and microalbuminuria in prediabetic patients (p>0.05); however, there was a significantly positive correlation between NLR and microalbuminuria in the group with HbA1c 5.7–6.49 (p<0.001). Except isolated IFG and IGT, there was a significantly positive correlation between MPV and microalbuminuria in all prediabetic patients according to the OGTT, HbA1c, and OGTT+HbA1c criteria (p<0.001). NLR and MPV levels may be reliable predictive markers for the detection of microalbuminuria in prediabetes and DM.

Anahtar Kelimeler

• Neutrophil/Lymphocyte Ratio
• Mean Platelet Volume
• Microalbuminuria
• Prediabetes
• Diabetes Mellitus

Farklı Glukoz Toleranslarına Sahip Katılımcılarda Nötrofil/Lenfosit Oranı (NLO) ve Ortalama Trombosit Hacmi (MPV) ile Mikroalbüminüri Arasındaki İlişki

Öz

Nötrofil/lenfosit oranı (NLO), kronik hastalıklar için subklinik inflamasyonun basit ve ucuz bir belirtecidir. Ortalama trombosit hacmi (MPV) bir trombosit fonksiyon indeksidir. Bu çalışma, farklı glukoz toleranslarına sahip katılımcılarda NLO ve MPV'nin mikroalbüminüri ile ilişkisini değerlendirmeyi amaçladı. 951 hasta (erkek / kadın = 302/649) oral glukoz tolerans testi (OGTT) sonuçlarına göre beş gruba ayrıldı: grup 1 = normal glikoz toleransı (NGT), grup 2 = bozulmuş açlık glikozu (BAG), grup 3 = izole bozulmuş glukoz toleransı (BGT), grup 4 = hem BAG hem de BGT ve grup 5 = tip 2 diabetes mellitus (DM). Ek olarak, hastalar glikolize hemoglobin (HbA1c) sonuçlarına göre üç gruba ayrıldı: grup 1 = NGT, grup 2 = prediyabet ve grup 3 = tip 2 DM. Sonuçlar gruplar arasında karşılaştırıldı. OGTT, HbA1c ve OGTT + HbA1c kriterlerine göre tüm DM hastalarında mikroalbüminüri ile MPV ve NLO arasında anlamlı pozitif korelasyon vardı (p <0.001). Ayrıca OGTT, HbA1c ve OGTT + HbA1c kriterlerine göre tüm NGT hastalarında MPV ile mikroalbüminüri arasında anlamlı pozitif korelasyon vardı (p <0.001). OGTT ve OGTT + HbA1c kriterlerine göre prediyabetik hastalarda NLO ile mikroalbüminüri arasında anlamlı bir ilişki yoktu (p> 0.05); ancak HbA1c 5,7–6,49 olan grupta NLO ile mikroalbüminüri arasında anlamlı pozitif korelasyon vardı (p <0,001). İzole BAG ve BGT dışında OGTT, HbA1c ve OGTT + HbA1c kriterlerine göre tüm prediyabetik hastalarda MPV ile mikroalbüminüri arasında anlamlı pozitif korelasyon vardı (p <0,001). NLO ve MPV seviyeleri prediyabet ve DM'de mikroalbüminüri tespiti için güvenilir prediktif belirteçler olabilir.

Anahtar Kelimeler

• Nötrofil/Lenfosit Oranı
• Ortalama Trombosit Hacmi
• Mikroalbüminüri
• Prediyabet
• Diabetes Mellitus

Kaynakça

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