Dapsone Induced Aplastic Anemia / Dapson Kaynaklı Aplastik Anemi

Yıl 2017, Cilt: 39 Sayı: 1, 90 - 93, 07.01.2017

Hava Üsküdar Teke , Çiğdem Karakükcü Hediye Uğur Salih Tokmak Ali Ünal

https://doi.org/10.20515/otd.288777

Öz

ABSTRACT: Dapsone is a sulfone antibiotic, which has
anti-inflammatory and anti-bacterial effects and used in leprosy, intractable
skin lesions, rheumatologic diseases like systemic lupus erythematosus and Pneumocystis jiroveci prophylaxis.
Aplastic anemia is an uncommon adverse hematologic effect in patients treated
with dapsone. We present a 59 years old female patient which developed aplastic
anemia, direct coombs positively and methemoglobinemia because of dapsone.
Before starting dapsone treatment, side effect profile must be discussed
thoroughly; periodic CBC must be performed before and after the treatment, even
without any patient complaints.

KEYWORDS: Dapsone, aplastic anemia, hemolysis

ÖZET: Dapsone, romatolojik hastalıklardan sistemik lupus
eritematozis ve Pneumocystis jiroveci
proflaksisi ile lepra ve inatçı cilt lezyonlarında kullanılan,
anti-inflamatuvar ve antibakteriyel özelliklere sahip bir sülfon
antibiyotiktir. Aplastik anemi, dapsonla tedavi edilen hastalarda nadir görülen
hematolojik bir yan etkidir. Bu yazıda dapsona bağlı aplastik anemi, direkt
coombs pozitifliği ve methemoglobinemi gelişen 59 yaşındaki kadın hastayı
sunduk. Dapson başlamadan önce ilacın yan etkileri dikkatli bir şekilde gözden
geçirilmeli, ilacı başlamadan önce ve başladıktan sonra periyodik olarak tam
kan sayımı yapılmalıdır.

ANAHTAR KELİMELER: Dapson, aplastik anemi, hemoliz

Anahtar Kelimeler

Dapsone, aplastic anemia

Kaynakça

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