Alzheimer Hastalığında Demirin Rolü

Yıl 2020, Cilt: 42 Sayı: 2, 254 - 257, 17.03.2020

Mevra Al Cansu Kılıç Fatma Sultan Kılıç

Öz

Alzheimer hastalığı
(AH), demans tablosunun en sık nedeni (%60-80) olan kronik nörodejeneratif bir
hastalıktır. Her yıl tüm dünyada 4.6 milyon yeni AH olgusu geliştiği tahmin
edilmektedir. Hastalığın görülme riski yaşa bağlı olarak logaritmik
biçimde artar. Yaşı 60-65 arasında olan popülasyonda görülme sıklığı
yaklaşık olarak %0.1 iken 85 yaşın üzerinde görülme sıklığı %47’ye kadar
çıkar. Tanı konulmasında özel bir belirteç olmaması, bilim adamlarını farklı
tanı yolları aramaya itmiştir. Bu nedenle yapılan incelemelerde serum demiri yüksek
ve transferrin saturasyonu düşük erişkinlerde nörolojik demansiyel hastalıkların
başlayabileceği ortalama 6 ay öncesinden öngörülebilmektedir. Serum demiri yüksekliği
beyin dokusunda da demir yüksekliğine yol açabilmektedir. Bu süreç, AH’de erken
tanı açısından faydalı olacaktır.

Anahtar Kelimeler

Alzheimer hastalığı

The Role of Iron in Alzheimer’s Disease

Öz

Alzheimer’s
disease is a chronical neurodegenerative disease and it is the most commanly
seen (%60-80) reason of dementia.  It is
predicted that every year 4.6 million new cases occur around the world. The
risk increases logarithmically depending on age. The incidence is %0.1 between
ages 60-65  while it is %47 over age 85.
Scientists are researching on  different
diagnostic methods since there isn’t a certain indicator for diagnosis.
Research showed that blood iron levels increasing and transferrin saturation
starts decreasing 6 months before the neurogical demential diseases occur. High
iron levels in blood serum causes high iron levels in the brain tissue. This
process will be useful for early diagnosis of AD.

Anahtar Kelimeler

Alzheimer Disease and blood iron levels

Kaynakça

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