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Tiroid ve Bilateral Adrenal Gland Metastazı olan Renal Hücreli Karsinom

Yıl 2025, Cilt: 47 Sayı: 1, 158 - 162, 17.01.2025
https://doi.org/10.20515/otd.1498147

Öz

Renal hücreli karsinom, vakaların %90’ından fazlasını temsil eden en yaygın malign böbrek hastalığı türüdür. Sıklıkla akciğerlere, kemiklere, karaciğere ve beyne metastaz yapar. Tiroid ve adrenal metastazlar nadirdir. Bu vaka raporunda, sağ radikal nefrektomiden üç yıl sonra iki taraflı adrenal metastaz ve beş yıl sonra tiroid metastazı gelişen renal hücreli karsinomlu 64 yaşındaki bir erkek hasta sunduk. Renal hücreli karsinomun yüksek metastaz oranı vardır ve dikkatli takip gerektirir. Non-invaziv görüntüleme yöntemlerinin artan kullanımı ile nadir görülen adrenal ve tiroid metastazlarının da tespit oranlarını artırmıştır. Bu tür vakaların nadir olması nedeniyle standart tedavi protokolleri iyi tanımlanmamıştır; bu da ameliyattan yıllar sonra bile dikkatli bir izlemenin gerekliliğini vurgulamaktadır.

Kaynakça

  • 1. Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, Gore JL, Sun M, Wood C, Russo P. Epidemiology of Renal Cell Carcinoma. European urology. 2019; 75(1):74-84.
  • 2. Nisi M, Izzetti R, Graziani F, Gabriele M. Renal Cell Carcinoma Metastases to the Oral Cavity: Report of 2 Cases and Review of Literature. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2020; 78(9):1557-1571.
  • 3. Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R. 2009 update on the classification of renal epithelial tumors in adults. International journal of urology: official journal of the Japanese Urological Association. 2009; 16(5):432-43.
  • 4. Iesalnieks I, Trupka A, Raab M, Glockzin G, Woenckhaus M, Schlitt HJ, Agha A. Renal cell carcinoma metastases to the thyroid gland-8 cases reported. Thyroid: official journal of the American Thyroid Association. 2007; 17(1):49-52.
  • 5. Karadağ D, Çağlar O. İki taraflı sürrenal metastazlı renal hücreli karsinom olgusu. Türk Üroloji Dergisi/Turkish Journal of Urology. 2011; 37(1): 67-70.
  • 6. HooKim K, Gaitor J, Lin O, Reid MD. Secondary tumors involving the thyroid gland: A multi-institutional analysis of 28 cases diagnosed on fine-needle aspiration. Diagnostic cytopathology. 2015; 43(11):904-11.
  • 7. Aljiabri KS, Bokhari SA, Fadag RB, et al. Thyroid metastasis from renal cell carcinoma, Archives of endocrinology and diabetes care. 2018; 1:65-70.
  • 8. Bohn OL, De las Casas LE, Leon ME. Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature. Head and neck pathology. 2009; 3(4):327-30.
  • 9. Romero Arenas MA, Ryu H, Lee S, Morris LF, Grubbs EG, Lee JE, Perrier ND. The role of thyroidectomy in metastatic disease to the thyroid gland. Annals of surgical oncology. 2014; 21(2):434-9.
  • 10. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M. Metastases to the thyroid: a review of the literature from the last decade. Thyroid: official journal of the American Thyroid Association. 2012; 22(3):258-68.
  • 11. Li Y, Ji Z, Wang D, Xie Y. Bilateral adrenal metastasis of renal cell carcinoma 4 years after radical nephrectomy: A case report and review of literature. Medicine (Baltimore). 2021; 100(31):e26838.
  • 12. Utsumi T, Suzuki H, Nakamura K, Kim W, Kamijima S, Awa Y, Araki K, Nihei N, Naya Y, Ichikawa T. Renal cell carcinoma with a huge solitary metastasis to the contralateral adrenal gland: a case report. International journal of urology: official journal of the Japanese Urological Association. 2008; 15(12):1077-9.
  • 13. Machens A, Dralle H. Outcome after thyroid surgery for metastasis from renal cell cancer. Surgery. 2010;147(1):65-71.
  • 14. Beutner U, Leowardi C, Bork U, et al. Survival after renal cell carcinoma metastasis to the thyroid: single center experience and systematic review of the literature. Thyroid. 2015;25(3):314-324.
  • 15. Iesalnieks I, Winter H, Bareck E, et al. Thyroid metastases of renal cell carcinoma: clinical course in 45 patients undergoing surgery. Assessment of factors affecting patients' survival. Thyroid. 2008;18(6):615-624.

Renal Cell Carcinoma with Thyroid and Bilateral Adrenal Gland Metastases

Yıl 2025, Cilt: 47 Sayı: 1, 158 - 162, 17.01.2025
https://doi.org/10.20515/otd.1498147

Öz

Renal cell carcinoma is the most common type of malignant kidney disease, representing more than 90% of cases. It frequently metastasizes to the lungs, bones, liver and brain. Thyroid and adrenal metastases are rare. In this case report, we present a 64-year-old man with renal cell carcinoma who developed bilateral adrenal metastases three years after right radical nephrectomy and thyroid metastases five years later. Renal cell carcinoma has a high metastasis rate and requires careful follow-up. The increasing use of non-invasive imaging modalities has increased the detection rates of rare adrenal and thyroid metastases. Due to the rarity of such cases, standard treatment protocols are not well defined, emphasizing the need for careful follow-up even years after surgery.

Kaynakça

  • 1. Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, Gore JL, Sun M, Wood C, Russo P. Epidemiology of Renal Cell Carcinoma. European urology. 2019; 75(1):74-84.
  • 2. Nisi M, Izzetti R, Graziani F, Gabriele M. Renal Cell Carcinoma Metastases to the Oral Cavity: Report of 2 Cases and Review of Literature. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2020; 78(9):1557-1571.
  • 3. Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R. 2009 update on the classification of renal epithelial tumors in adults. International journal of urology: official journal of the Japanese Urological Association. 2009; 16(5):432-43.
  • 4. Iesalnieks I, Trupka A, Raab M, Glockzin G, Woenckhaus M, Schlitt HJ, Agha A. Renal cell carcinoma metastases to the thyroid gland-8 cases reported. Thyroid: official journal of the American Thyroid Association. 2007; 17(1):49-52.
  • 5. Karadağ D, Çağlar O. İki taraflı sürrenal metastazlı renal hücreli karsinom olgusu. Türk Üroloji Dergisi/Turkish Journal of Urology. 2011; 37(1): 67-70.
  • 6. HooKim K, Gaitor J, Lin O, Reid MD. Secondary tumors involving the thyroid gland: A multi-institutional analysis of 28 cases diagnosed on fine-needle aspiration. Diagnostic cytopathology. 2015; 43(11):904-11.
  • 7. Aljiabri KS, Bokhari SA, Fadag RB, et al. Thyroid metastasis from renal cell carcinoma, Archives of endocrinology and diabetes care. 2018; 1:65-70.
  • 8. Bohn OL, De las Casas LE, Leon ME. Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature. Head and neck pathology. 2009; 3(4):327-30.
  • 9. Romero Arenas MA, Ryu H, Lee S, Morris LF, Grubbs EG, Lee JE, Perrier ND. The role of thyroidectomy in metastatic disease to the thyroid gland. Annals of surgical oncology. 2014; 21(2):434-9.
  • 10. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M. Metastases to the thyroid: a review of the literature from the last decade. Thyroid: official journal of the American Thyroid Association. 2012; 22(3):258-68.
  • 11. Li Y, Ji Z, Wang D, Xie Y. Bilateral adrenal metastasis of renal cell carcinoma 4 years after radical nephrectomy: A case report and review of literature. Medicine (Baltimore). 2021; 100(31):e26838.
  • 12. Utsumi T, Suzuki H, Nakamura K, Kim W, Kamijima S, Awa Y, Araki K, Nihei N, Naya Y, Ichikawa T. Renal cell carcinoma with a huge solitary metastasis to the contralateral adrenal gland: a case report. International journal of urology: official journal of the Japanese Urological Association. 2008; 15(12):1077-9.
  • 13. Machens A, Dralle H. Outcome after thyroid surgery for metastasis from renal cell cancer. Surgery. 2010;147(1):65-71.
  • 14. Beutner U, Leowardi C, Bork U, et al. Survival after renal cell carcinoma metastasis to the thyroid: single center experience and systematic review of the literature. Thyroid. 2015;25(3):314-324.
  • 15. Iesalnieks I, Winter H, Bareck E, et al. Thyroid metastases of renal cell carcinoma: clinical course in 45 patients undergoing surgery. Assessment of factors affecting patients' survival. Thyroid. 2008;18(6):615-624.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Genel Cerrahi
Bölüm OLGU SUNUMLARI / CASE REPORTS
Yazarlar

Bartu Badak 0000-0003-3465-8719

İbrahim Kısalar 0009-0002-2316-0093

Arda Şakir Yılmaz 0000-0003-1269-0814

Emel Yaldir 0000-0001-7297-9869

Yayımlanma Tarihi 17 Ocak 2025
Gönderilme Tarihi 8 Haziran 2024
Kabul Tarihi 12 Kasım 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 47 Sayı: 1

Kaynak Göster

Vancouver Badak B, Kısalar İ, Yılmaz AŞ, Yaldir E. Renal Cell Carcinoma with Thyroid and Bilateral Adrenal Gland Metastases. Osmangazi Tıp Dergisi. 2025;47(1):158-62.


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