Memenin Anjiyosarkomu: Olgu Sunumu

Yıl 2025, Cilt: 47 Sayı: 1, 146 - 150, 17.01.2025

Bartu Badak , Arda Şakir Yılmaz , Mithat Mert Yurdakul , Nazlı Sena Seker , Furkan Albayrak

https://doi.org/10.20515/otd.1516838

Öz

Anjiyosarkom, memede nadir görülen ve endotel hücrelerinden kaynaklanan agresif bir tümördür. Genellikle kronik lenfödem veya radyasyon tedavisi ile ilişkilidir. Tanı biyopsi ile konur ve mamografide spesifik bir bulgusu yoktur. Bu çalışmada, invaziv duktal karsinom nedenli radyoterapi öyküsü olan ve sonrasında primer meme anjiyosarkomu gelişen 59 yaşındaki kadın hasta sunulmaktadır. Memenin anjiyosarkomu, ilk olarak 1887 yılında belgelenmiş olup, primer ve sekonder olarak sınıflandırılır. Etiyolojisi tam olarak açıklanamamış olan bu tümörlerin tedavisi için cerrahi R0 rezeksiyon önerilirken, aksiller lenf nodu diseksiyonunun önemi belirsizdir. Adjuvan radyoterapinin lokal rekürrens oranını azalttığı, ancak adjuvan kemoterapi ve radyoterapinin 5 yıllık sağ kalım üzerinde belirgin bir etkisi olmadığı görülmüştür. Tedavi rejimleri konusunda fikir birliği olmamakla birlikte, daha geniş örneklemde daha kapsamlı çalışmalar yapılması gerektiği sonucuna varılmıştır.

Anahtar Kelimeler

Meme, anjiyosarkom, radyoterapi

Angiosarcoma of the Breast: Case Report

Öz

Angiosarcoma is a rare and aggressive tumor of the breast arising from endothelial cells. It is usually associated with chronic lymphedema or radiation therapy. The diagnosis is made by biopsy and there is no specific finding on mammography. In this study, we report a 59-year-old woman with a history of radiotherapy for invasive ductal carcinoma who subsequently developed primary angiosarcoma of the breast. Angiosarcoma of the breast was first documented in 1887 and is classified as primary and secondary. While surgical R0 resection is recommended for the treatment of these tumors with unclear etiology, the significance of axillary lymph node dissection remains uncertain. Adjuvant radiotherapy has been shown to reduce the local recurrence rate, but adjuvant chemotherapy and radiotherapy have no significant effect on 5-year survival. Although there is no consensus on treatment regimens, it is concluded that more comprehensive studies should be conducted in a larger sample.

Anahtar Kelimeler

Breast, angiosarcoma, radiotherapy

Kaynakça

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