Endometrial Hiperplazi ile Komplike Obez ve Premenopozal Hastalarda Vücut Yağ Dokusu Dağılımının Etkisi

Öz

Amaç: Obezite ile adet düzensizliği arasında yakın bir ilişki vardır.Bu çalışmanın amacı, endometriyal hiperplazili aşırı kilolu veya obez premenopozal hastalar ile benign patolojik lezyonları olan gönüllüler arasında biyoimpedans yöntemi kullanılarak lipoid doku dağılımının araştırılmasıdır.

Materyal ve Metot: Anormal uterin kanama tanılı obez veya aşırı kilolu gönüllüler incelendi. 88 hasta dahil etme kriterleini karşıladı. Multi-Frequency Body Composition Analyzer kullanarak vücut bölümlerinin yağ kütlesi, yağ yüzdesi ve empedans ölçümleri yapıldı. Tüm gönüllüler için kan lipid profili ölçümü ve endometriyal kalınlığın ultrasonografik ölçümü yapıldı.

Bulgular: Hiperplazi grubunda 33, kontrol grubunda 55 gönüllü mevcuttu. Endometriyal hiperplazi grubundaki 33 gönüllünün 28'inde (%84.8) en az bir artmış yağ asidi tespit edildi. Kontrol grubundaki 55 hastanın 41'inde (%74.5) en az bir artmış yağ asidi mevcuttu. Total kolesterol düzeyleri hiperplazi grubunda kontrol grubuna göre daha yüksek bulundu (p=0.006). Biyoimpedans analizleri için hiperplazi ve kontrol grubu arasında anlamlı bir fark yoktu.

Sonuç: Hiperlipideminin endometriyal patolojilere katkıda bulunan önemli bir faktör olmaya devam ettiği yaptığımız bu çalışmada da görülmüştür. Endometrial hiperplazi grubunda serum kolesterol düzeyleri anlamlı olarak yüksek bulunması, endometriyal hiperplazi ile komplike olan obez bireylerde, lipoid doku dağılımından ziyade, artan kolesterol düzeyinin jinekolojik patoloji oluşumuna katkıda bulunabileceğini göstermektedir. 

Anahtar Kelimeler

• Endometrial hiperplazi
• hiperlipidemi
• kolesterol
• obezite
• yağ dağılımı

The Effect of Body Fat Tissue Distribution in Obese and Premenopausal Patients Complicated with Endometrial Hyperplasia

Öz

Objective: There is a close association between obesity and menstrual irregularity. This study aims to investigate lipoid tissue accumulation between overweight or obese premenopausal patients with endometrial hyperplasia and with benign pathologic lesions via using the bioimpedance method.
Materials and Methods: Obese or overweight volunteers with abnormal uterine bleeding were examined. Eighty-eight volunteers meet the inclusion criteria. We obtained fat mass, fat percentage and impedance of body parts by using Multi-Frequency Body Composition Analyzer. Blood lipid profile and ultrasonographic measurement of endometrial thickness were also performed.
Results: 33 volunteers were in the hyperplasia group and 55 were in the control group. 28 of the 33 volunteers (84.8%) had at least one increased fatty acid. 41 of the 55 patients (74.5%) had at least one increased fatty acid in the control group. Total cholesterol levels are higher in the hyperplasia group than in the control group (p=0.006). There was no significant difference between the groups for bioimpedance analyses.
Conclusion: Hyperlipidemia remains an important factor that contributes to endometrial pathologies. Serum cholesterols were significantly high in the endometrial hyperplasia group. Rather than lipoid tissue distribution, increased cholesterol may contribute to gynecologic pathology occurrence in obese individuals complicated with endometrial hyperplasia. 

Anahtar Kelimeler

• Cholesterol
• endometrial hyperplasia
• fat distribution
• hyperlipidemia
• obesity

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