High Serum Osmolality May Predict the Disease Severity in Patients with Acute Ulcerative Colitis

Abstract

Objective: Ulcerative colitis (UC) is characterised by chronic immun- mediated inflammation of the colonic mucosa. The Truelove and Witts (TW) criteria have been used to define the severity of the UC. Otherhand, a simplier and unified laboratory tool is needed for better definition of high risk patients with UC. The aim of the study, especially in emergency service applications, was to determine the usefulness of serum osmalality as a biomarker which can easily and rapidly predict the severity of the disease, in which the patient will be advised to be hospitalized after the symptomatic treatment. 

Materials and Methods: In this single-center, retrospective cohort study, we collected data of 62 hospitalized patients with UC such as demographic characteristics and blood sample results evaluated by clinicians. Truelove and Witts (TW) scores of the patients along with serum osmolality were calculated. Stata 14.0. package program was used for data analysis. P <0.05 was considered statistically significant. 

Results: According to our results, patients with hyperosmolality were more likely to have severe UC as defined by having higher scores of TW criteria at baseline.

Conclusion: As a conclusion, serum osmolality can be considered as an useful predictor to demonstrate the severity of the disease.

Keywords

• Acute ulcerative colitis,serum osmolality,Truelove Witt’s score

Yüksek Serum Osmolalitesi Akut Ülseratif Kolit Hastalarında Hastalık Şiddetini Tahmin Edebilir

Öz

Amaç: Ülseratif kolit (ÜK), kolon mukozasının kronik immün aracılı enflamasyonu ile karakterizedir. ÜK’nin ciddiyetini tanımlamak için Truelove ve Witts (TW) kriterleri kullanılmıştır. Diğer taraftan, ÜK’li yüksek riskli hastaların daha iyi tanımlanabilmesi için daha basit bir laboratuvar aracına ihtiyaç vardır. Çalışmanın amacı, özellikle acil servis uygulamalarında, hastanın semptomatik tedaviden sonra hastaneye yatırılması gerekliliğini öngörebilen ve hastalığın ciddiyetini kolayca ve hızlı bir şekilde tahmin edebilen bir biyobelirteç olarak serum osmalalitesinin yararlılığını belirlemektir. 

Materyal ve Metot: Bu tek merkezli, retrospektif kohort çalışmasında ÜK’li 62 hastanın demografik özellikleri ve kan örnek sonuçları değerlendirildi ve veriler toplandı. Serum osmolalitesi ile birlikte hastaların Truelove ve Witts (TW) skorları hesaplandı. Data analizinde stata 14.0. paket programı kullanıldı. P < 0,05 istatiksel olarak anlamlı kabul edildi. 

Bulgular: Çalışma sonunda, yüksek osmolaliteli hastaların daha yüksek olasılıkla şiddetli ülseratif kolite, yüksek TW skoru, sahip oldukları görülmüştür.

Sonuç: Sonuç olarak, serum osmolalitesi hastalığın ciddiyetini göstermek için yararlı bir belirleyici olarak düşünülebilir.

Anahtar Kelimeler

• Akut ülseratif kolit,serum ozmolalitesi,Truelove Witt’s skoru

Kaynakça

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