Correlation of E-Cadherin/Beta Catenin Expression with Localization in Squamous Epithelial Cell Carcinoma and Basal Cell Carcinoma

Abstract

Objective: The aim of this study is to determine whether E-cadherin and β-catenin levels in cases with squamous epithelial cell cancer observed in certain regions of the body vary according to the patient’s age, gender, tumor localization and tumor type. Materials and Methods: The sample of this retrospective study was the samples of 53 patients who applied to Ordu University Training and Research Hospital and who were diagnosed with flat epithelial cell tumors on the skin. in the sample; It was evaluated immunohistochemically in terms of β –catenin and E-cadherin. Results: There was no difference between the age distribution of the patients (p> 0.05). β-catenin and Ecadherin scores; It does not change according to the gender and the location of the sample (p= 0.129, 0.106 and 0.259, 0.120, respectively). According to the tumor type, it was determined that β-catenin scores did not change but E -cadherin changed significantly (p =0.721, 0.013, respectively). Conclusions: According to the tumor type, it was determined that E-cadherin scores changed significantly. Scientific studies to be carried out by enlarging the sample width will contribute significantly to the result.

Keywords

• Basal cell
• β –catenin
• E- kadherin
• squamaus epithelium

Yassı Epitel Hücreli Karsinom ve Bazal Hücreli Karsinomlarda E-Kadherin, β- Katenin Ekspresyonunun Lokalizasyonla İlişkisi

Öz

Amaç: Bu çalışmanın amacı; vücudun bazı bölgelerinde görülen yassı epitel hücreli karsinom vakalarında Ekadherin ve β-katenin düzeylerinin; hastaların yaşı, cinsiyeti, karsinomların yerleşim yeri ve tümör tipine göre değişip değişmediğini ortaya koymaktır. Materyal ve Metot: Retrospektif olarak yapılan bu çalışmanın örneklemini Ordu Üniversitesi Eğitim Araştırma hastanesine müracaat eden ve deride yassı epitel hücreli karsinom tanısı almış olan 53 hastanın numuneleri oluşturdu. Numuneler E-kadherin ve β-katenin yönünden immünohistokimyasal olarak değerlendirildi. Bulgular: Hastaların yaş dağılımları arasında fark tespit edilmedi (p>0,05). β-katenin ve E- kadherin skorları; cinsiyet ve numunenin alındığı yerleşim yerine göre değişmemektedir (p değerleri sırasıyla; 0,129, 0,106 ve 0,259, 0,120). Tümör tipine göre ise β-katenin skorlarının değişmediği fakat E- kadherin skorlarının önemli oranda değiştiği belirlendi (sırasıyla p değeri; 0,721, 0,013). Sonuç: E-kadherin boyama şiddetinin patolojik tanı tipine göre değiştiği belirlendi. Örneklem genişliği büyütülerek yapılacak bilimsel çalışmalar sonuca önemli katkı sağlayacaktır.

Anahtar Kelimeler

• Bazal hücre
• β-katenin
• E- kadherin
• yassı epitel

Kaynakça

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