Elektrolif çekim yöntemi ile β-arbutin içeren nanolifli tekstil yüzeyi üretimi

Öz

Bu çalışmada, cilt lekeleri azaltıcı etkisi bilinen β-arbutin ilave edilmiş polimer çözeltisinden nanoliflerin elektrolif çekim yöntemi ile üretimi amaçlanmıştır. Bu amaçla %2, %5 ve %10 (w/v) oranlarında β-arbutin, formik asit ile hazırlanmış poliamid 6 çözeltisine ilave edilerek, çözeltilerin elektrolif çekimleri gerçekleştirilmiş ve gerçekleştirilen taramalı elektron mikroskobu (SEM) analizi ile optimum elektrolif çekim parametreleri belirlenmeye çalışılmıştır. SEM görüntüleri, en düzgün morfolojili nanoliflerin %2 (w/v)’lik β-arbutin içeren çözelti ile elde edilebildiğini göstermiştir. %2 (w/v) konsantrasyon değeri ile çalışılırken denenen 3 farklı voltajdan 30 kV’un en iyi sonucu verdiği gözlemlenmiştir. Ortalama lif çapları için gerçekleştirilen istatistiksel analizde, nanoliflerin çaplarının konsantrasyon değerlerine göre değiştiği belirlenmiştir. Bu çalışmada, cilt lekeleri azaltıcı madde içeren nanolifli tekstil yüzeylerinin hafif ve oldukça ince formda bir kozmetik tekstil ürünü olarak kullanılmak üzere elektrolif çekim yöntemi ile üretilebileceği gözler önüne serilmiştir.

Anahtar Kelimeler

• Nanolif
• Elektrolif çekim
• Kozmetik tekstil
• Nanolifli tekstil yüzeyi
• Cilt lekeler

Production of nanofiber textile surfaces with β-arbutin via electrospinning method

Abstract

In this study, it is aimed to produce nanofibers via electrospinning method using a polymer solution doped with β-arbutin, which is known as an agent reducing skin blemishes. For this purpose, β-arbutin was added to the polyamide 6/formic acid solution with chosen concentrations as 2%, 5%, and 10% (w/v). After preliminary electrospinning process, scanning electron microscope (SEM) analysis was performed to determine the optimum spinning parameters. The SEM images presented that nanofibers with uniform morphology were obtained with the 2% (w/v) β-arbutin concentration. Three different voltages were applied for 2% (w/v) β-arbutin added solution and the best morphology was obtained by 30 kV voltages. According to the statistical analysis performed, it was seen that the mean diameters of nanofibers varied due to the β-arbutin concentration. In this study, it has been demonstrated that the thin and light nanofiber textile surfaces containing skin blemishes reducing agent can be produced via electrospinning method to be used as a cosmetic textile product.

Keywords

• Nanofibers
• Electrospinning
• Cosmetic textile
• Nanofiber
• Textile surface
• Skin blemishes

Kaynakça

1. [1] Chaudhri SK, Jain NK. “History of cosmetics”. Asian Journal of Pharmaceutics, 3(3), 164-167, 2009.
2. [2] Yapar EA, Ölgen S. “Cosmetics and in silico approaches”. Journal of Marmara University Institute of Health Sciences, 4(4), 253-260, 2014.
3. [3] Patil A, Sandewicz RW. Cosmetic Science and Polymer Chemistry: Perfect Together. Editors: Patil A, Ferritto MS. Polymers for Personal Care and Cosmetics, 13-37, Washington, USA, American Chemical Society, 2013.
4. [4] Özkaleli M, Erdem A. “Nanoatıklar ve çevre: Atık yönetiminde yeni bir yaklaşım”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 22(3), 183-188, 2016.
5. [5] Pokropivny V, Lohmus R, Hussainova I, Pokropivny A, Vlassov S. Introduction to Nanomaterials and Nanotechnology. 1st ed. Estonia, Tartu University Press, 2007.
6. [6] Yilmaz F, Celep G, Tetik G. Nanofibers in Cosmetics. Editors: Rahman M and Asiri AM, Nanofiber Research-Reaching New Heights, 127-146, Croatia, Intechopen, 2016.
7. [7] Ko FI. Nanofiber Technology: Bridging the Gap Between nano and Macro World. Editors: Guceri S, Gogotsi YA. Nanoengineered Nanofibrous Materials, 18 p, Chichester, England, Kluwer Academic Publishers, 2004.
8. [8] İkiz Y.“Elektro çekim yöntemi işlem parametrelerinin PVA nanolif morfolojisine etkileri”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 15(3), 363-369, 2009.

9. [9] Evcin A, Bezir NÇ, Kayalı R, Mehmet ARI, Küçük A. “Elektroeğirme yöntemiyle üretilen GaInP nanoliflerin elektriksel ve optik karakterizasyonu”. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, 14(3), 303-306, 2005.
10. [10] Lukáš D, Sarkar A, Martinová L, Vodsed'álková K, Lubasová D, Chaloupek J, Pokorný P, Mikeš P, Chvojka J, Komárek M. “Physical principles of electrospinning (Electrospinning as a nanoscale technology of the twentyfirst century)”. Textile Progress, 41(2), 59- 140, 2009.
11. [11] Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S. “A Review on polymer nanofibers by electrospinning and their applications in nanocomposites”. Composite Science and Technology, 63(15), 2223-2253, 2003.
12. [12] Doğan G. Elektrolif Çekim Yöntemiyle Elde edilen Biyopolimer Nanoliflerin Doku Mühendisliği ve İlaç Salımı Uygulamalarında Kullanım Olanaklarının Araştırılması. Doktora Tezi, Ege Üniversitesi, İzmir, Türkiye, 2012.
13. [13] Wen JC, Bin JX, Xiang JW. “Fabrication and characterization of PSA nanofibers via electrospinning”. Journal of Industrial Textiles, 44(1), 159-179, 2014.
14. [14] Valipouri A, Ravandi SAH, Pishevar A. “Optimization of the parameters involved in fabrication of solid state polymerized polyamide (SSP PA66) nanofibers via an enhanced electro-centrifuge spinning”. Journal of Industrial Textiles, 45, 368-386, 2015.
15. [15] Liu H, Zuo B. “Sound absorption property of PVA/PEO/GO nanofiber membrane and non-woven composite material”. Journal of Industrial Textiles, 50(4), 512-525, 2020.
16. [16] Doğan G, Başal BG, Bayraktar O, Ozyildiz F, Uzel A, Erdogan I. “Bioactive sheath core nanofibers containing olive leaf extract”. Microscopy Research and Technique, 79(1), 38-49, 2016.
17. [17] Fathi-Azarbayjani A, Qun L, Chan YW, Chan SY. “Novel vitamin and gold-loaded nanofiber facial mask for topical delivery”. American Association of Pharmaceutical Scientists, 11(3), 1164-1170, 2010.
18. [18] Kim C. “Cosmetic Sheet Formed from Nanofiber with Controlled Dissolution Velocity and Method of Manufacturing the same”. U.S. Patent 20150272855, 2015.
19. [19] Smith D, Reneker D, Kataphinan W, Dabney S. “Electrospun Skin Masks and Uses Thereof”. PCT Patent WO 01/26610 A1, 2001.
20. [20] Taepaiboon P, Rungsardthong U, Supaphol P. “Vitaminloaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E”. European Journal of Pharmaceutics and Biopharmaceutics, 67(2), 387-397, 2007.
21. [21] Sheng X, Fan L, He C, Zhang K, Mo X, Wang H. “Vitamin Eloaded silk fibroin nanofibrous mats fabricated by green process for skin care application”. International Journal of Biological Macromolecules, 56, 49-56, 2013.
22. [22] Charernsriwilaiwat N, Rojanarata T, Ngawhirunpat T, Sukma M, Opanasopit P. “Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts”. International Journal of Pharmaceutics, 452(1-2), 333-343, 2013.
23. [23] Karakaya G. Kojik Asit Türevi Mannich Bazlarını Sentezi ve İnsan Melanoma Hücrelerine Etkisi ile Antitirozinaz Aktivitelerinin Araştırılması. Doktora Tezi, Hacettepe Üniversitesi, Ankara, Türkiye, 2017.
24. [24] Zhu W, Gao J. “The use of botanical extracts as topical skinlightening agents for the improvement of skin pigmentation disorders”. Journal of Investigative Dermatology Symposium Proceedings, 13(1), 20-24, 2008.
25. [25] Maeda K, Fukuda M. “Arbutin: mechanism of its depigmenting action in human melanocyte culture”. Journal of Pharmacology and Experimental Therapeutics, 276(2), 765-769, 1996.
26. [26] Sugimoto K, Nomura K, Nishimura T, Kiso T, Sugimoto K, Kuriki T. “Syntheses of α-arbutin-α-glycosides and their inhibitory effects on human tyrosinase”. Journal of Bioscience and Bioengineering, 99(3), 272-276, 2005.
27. [27] Sugimoto K, Nishimura T, Nomura K, Sugimoto K, Kuriki T. “Inhibitory effects of α-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model”. Biological and Pharmaceutical Bulletin, 27(4), 510-514, 2004.
28. [28] Hu ZM, Zhou Q, Lei TC, Ding SF, Xu SZ. “Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation: Biosafety as skin whitening agents”. Journal of Dermatological Science, 55(3), 179-184, 2009.
29. [29] Seo DH, Jung JH, Ha SJ, Cho HK, Jung DH, Kim TJ, Park CS. “High-yield enzymatic bioconversion of hydroquinone to α-arbutin, a powerful skin lightening agent, by amylosucrase”. Applied Microbiology and Biotechnology, 94(5), 1189-1197, 2012.
30. [30] Deitzel JM, Kleinmeyer J, Harris D, Beck TNC. “The effect of processing variables on the morphology of electrospun nanofibers and textiles”. Polymer, 42(1), 261-272, 2001.