Atenolol tayini için nafion ve çok duvarlı karbon nanotüp kaplı camsı karbon elektrot kullanılarak ultra hassas yöntem geliştirilmesi

Yıl 2018, Cilt: 24 Sayı: 7, 1287 - 1292, 28.12.2018

Hilal Çelik Kazıcı

Öz

Atenolol
(Şekil 1), hipertansiyon tedavisinde yaygın olarak kullanılan β-bloker grubunu
oluşturan antihipertansif ilaçtır. Bu çalışmada; Tansiyon tedavisinde
kullanılan Tensinör ilacının redoks özellikleri, modifiye camsı karbon elektrot
ve bu modifiye elektrot üzerine karbon nano tüp kaplanarak hazırlanmış
elektrotlarda incelenmiştir. Nafion kaplı çok duvarlı karbon nanotüp (MWCNT/NGCE)
elektrot yanıtı ile Nafion kaplı camsı karbon elektrot (NGCE) ve sadece camsı
karbon elektrot (GCE) yüzeylerinin elektrot yanıtlarının destek elektroliti,
pH, ve tarama hızı üzerine etkilerini araştırmak için Çevrimsel voltametri (CV)
ve Diferansiyel puls voltametri (DPV) yöntemleri kullanılmıştır. Atenolol (ATN)
Britton-Robinson (BR) tampon çözeltisinde (pH 7.0) 1.11 V (vsAg/AgCl (3.0 mol
L-1 KC1) civarında gözlenmiştir. Voltametrik yöntem, optimum analitik deney
koşulları altında, 3x10-5 µM -9x10-2 mM konsantrasyon aralığında lineer tepki
göstermiştir. Britton-Robinson (BR) (pH=7) tamponundaki Tensinör belirme sınırı
sonuçları, sırasıyla 7.67 x 10-5 mM ve 2.5x10-4 mM olarak bulunmuştur. Ayrıca
çalışmada ilaçların hazırlanmasında kullanılan yardımcı maddeler ile girişim
etkisi deneyleri gerçekleştirilmiş ve olumsuz bir etkiye rastlanmamıştır.

Anahtar Kelimeler

Çevrimsel voltametri, Atenolol, Karbon nano tüp

Development of an ultra-sensitive method using nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

Öz

Atenolol
(Scheme 1) is antihypertensive drug that form β-blocker group, which widely
used in the treatment of hypertension In this study, the redox properties of
the Tensinor drug used in blood pressure treatment were examined on modified
glassy carbon electrode and the electrodes prepared by coating carbon nanotubes
on this modified electrode. In order to investigate the effects of nafion
coated multi-walled glass nanotube (MWCNT / NGCE) electrode response and nafion
coated glassy carbon electrode (NGCE) and electrode responses of only glassy
carbon electrode (GCE) surfaces on the support electrolyte, pH and scan rate,
the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods
were used. Atenolol (ATN) was observed in the Britton-Robinson (BR) buffer
solution (pH 7.0) thereabouts 1.11 V (vsAg / AgCl (3.0 mol L-1 KCl). Voltammetric
method reacted linear at a concentration range between 3x10-5 μM and 9x10-2 μM
under optimum analytical experimental conditions. The results of Tensinor's
limit of detection on the Britton-Robinson (BR) (pH=7) buffer were found to be
7.67 x 10-5 mM and 2.5 x 10-4 mM, respectively. Additionally, in the study,
interference effects experiments were performed with auxiliary substances used
in the preparation of medicines and no negative effect was observed.

Anahtar Kelimeler

Cyclic voltammetry, Atenolol, Carbon nano tube

Kaynakça

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