Evaluation of clinical and demographic data of children with chronic spontaneous urticaria in Antalya province.

Öz

Purpose: The aim of the study was to investigate the etiology of chronic urticaria in children and the related clinical and laboratory findings in our city.

Materials and methods: 107 patients aged between 7-17 years who were diagnosed with CSU in our clinic were retrospectively reviewed. Demographic and clinical characteristics were evaluated. In addition, Urticaria Activity Score (UAS) and Urticaria Control Test (UCT) were applied to evaluate disease severity.

Results: A total of 107 patients with a mean age of 11.99±3.34 were evaluated. Angioedema was associated with 66% of the patients. The mean duration of urticaria was 13.5±15.10 months. Allergic diseases were associated with 36% of the patients. 12% of patients had asthma and 21% had allergic rhinitis. In 33% of cases, inhalant sensitivity and 6.5% of food sensitivity were determined. Antinuclear antibody (ANA) positivity was found in 16.8%, thyroid autoantibody was present in 6.5%, urinary tract infection was found in 3%, helicobacter pylori positivity was found in 1.9% and had positive stool examination for parasites. The mean UAS7 was 12.96±9.8 and the mean UCT was 8.43±2.8. No significant difference was found between the groups in terms of age, gender, presence of angioedema, duration of disease and ANA positivity when compared with control (n=24) and uncontrolled (n=83) patients (respectively, p=0.842, p=0.646, p=0.347, p=0.590, p=0.316).

Conclusion: In children, atopic diseases, infections, parasitic infestations are present in the etiology of CSF, where as in most cases the diagnosis remains idiopathic.

Anahtar Kelimeler

• Chronic urticaria,childhood,autoimmune thyroiditis,urticaria control test,urticaria activity scoring

Antalya il merkezinde kronik spontan ürtikeri olan çocukların klinik ve demografik verilerinin değerlendirilmesi.

Öz

Amaç: Çalışmada, ilimizdeki çocuklarda KSÜ etiyolojisinde rol oynayabilecek faktörler ve ilişkili klinik ve laboratuvar bulguların araştırılması amaçlandı.

Yöntemler: Kliniğimizde KSÜ tanısı alan 7-17 yaş arası 107 hastanın kayıtları retrospektif olarak incelendi.  KSÜ’lü hastaların demografik ve klinik özellikleri, laboratuvar bulguları, atopi, enfeksiyon, otoimmüniteye yönelik tetkikleri değerlendirildi. Ek olarak hastalık şiddetinin değerlendirilmesi için Ürtiker Aktivite Skoru (ÜAS7)  ve hastalık kontrolünün değerlendirilmesi için Ürtiker Kontrol Testi (ÜKT) uygulandı.

Bulgular: Ortalama yaşı 11,99.2±3,34 olan 107 hasta çalışmaya dahil edildi. Hastaların %66’sına anjioödem eşlik etmekteydi.  Ürtiker ortalama süresi 13,5±15,10 ay idi.  Hastaların %36’sına alerjik hastalıklar eşlik etmekte idi. Hastaların %12’sinde astım ve %21’inde alerjik rinit öyküsü vardı. Olguların %33’ünde inhalen duyarlılığı ve  % 6,5’inde besin alerjen duyarlılığı saptandı. %16,8’inde antinükleer antikor (ANA) pozitifliği, %6,5’inde tiroid otoantikor varlığı, %3’ünde idrar yolu enfeksiyonu, %1,9’ unda helikobakter pylori pozitifliği ve gaitada parazit tespit edildi.ÜAS7 ortalaması 12,96±9,8 ve ÜKT ortalaması 8,43±2,8 idi. ÜKT kontrollü (n=24) ve kontrolsüz (n=83) olan hastalar karşılaştırıldığında, yaş cinsiyet, anjioödem varlığı, hastalık süresi ve ANA pozitifliği açısından gruplar arasında anlamlı bir fark saptanmadı (sırasıyla, p=0,842, p=0,646, p=0,34, p=0,590, p=0,316).

Sonuç: Çocuklarda KSÜ etiyolojisinde atopik hastalıklar, enfeksiyonlar, paraziter enfestasyonlar yer tutarken çoğu vakada tanı idiyopatik olarak kalmaktadır.

Anahtar Kelimeler

• Kronik ürtiker,çocuklar,otoimmün tiroidit,otoimmün tiroidit,ürtiker kontrol test,ürtiker aktivite skorlaması

Kaynakça

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