Evaluation of osteoporosis and the risk of secondary fractures in postmenopausal 55- 60 years old patients with type-2 diabetes mellitus

Abstract

Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi

Öz

Tip 2 DM hastalarda KMD değerlerinden bağımsız olarak kırık riskinde artış olduğunu gösteren meta analizler mevcuttur. Diyabette kemik frajilitesindeki artış pentosidin ile ilişkilendirilmiştir. Çalışmamızda postmenopozal Tip 2 DM hastalarda kontrol grubuna göre diyabete bağlı olarak artmış kırık riskini ortaya koymak için WHO FRAX ölçeğini kullanarak hesapladığımız kırık riski yüzdesi ile kemik turnover belirteçleri, sclerostin ve pentosidin düzeylerinin ilişkisini göstermeyi planladık. Çalışmaya 55-65 yaş arası 80 postmenopozal kadın alındı. 50 kişi Tip 2 DM grubuna ve 30 kişi (DM olmayan) kontrol grubuna alındı. Çalışmaya sekonder osteoporoz nedenlerine sahip hastalar alınmadı. Diyabetik ve kontrol grubu arasında kırık riski yüzdeleri ve kemik turnover belirteçleri, pentosidin, sclerostin düzeyleri arasında anlamlı fark saptanmadı. Ayrıca kırık riski yüzdesi, KMD değerleri ile serumda bakılan belirteçler arasında korelasyon saptanmadı. Diyabetik hastalarda osteoporoza bağlı kırık riskini değerlendirmede KMD yetersiz olup, kandaki belirteçlerden faydalanılması ve FRAX a entegre edilebilmesi için yeni çalışmalara ihtiyaç vardır. There are some meta analysis about high fracture risk in type 2 DM group, independent of high BMD values. Fracture risk in DM; related with Pentosidine. In this study we aimed to determine whether there is a relation between bone turnover markers, pentosidin, sclerostin and increased fracture risk, calculated with WHO FRAX algoritm. In totaly, 80 postmenupausal women between ages 55-65 were included to this study. 50 patients with type 2 DM for DM group and 30 patients choosed for control group. Patients who have seconder osteoporosis were excluded. As a result of study there was no significant difference between with diabetics and control group as following parameters: Bone turnover markers, pentosidin and sclerostin levels and fracture risk percentages. Morover, among the markers assesed by fracture risk persentages no significant correlation determined.

Anahtar Kelimeler

• Osteoporoz
• Tip 2 DM de fraktür riski
• pentosidin
• sclerostin

Kaynakça

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