Evaluation of the relationship of leptin, adiponectin and carnitine levels with lung function, asthma severity and BMI in children with asthma

Öz

Purpose: The aim of this study is to evaluate the relationship between serum levels of leptin, adiponectin and carnitine with lung function, disease severity and BMI (Body Mass Index) in children with asthma. Materials and methods: 97 Pediatric patients with not in acute attack period bronchial asthma and 40 healthy control subjects were included in the study. Pulmonary function tests done to all asthma patients with a spirometer. Children with asthma were divided into 3 groups according to GINA criteria, mild intermittent, mild persistent, and moderate persistent, with using symptoms and spirometric parameters according to the severity of airway obstruction. Leptin, total carnitine and adiponectin analyzes were performed from venous blood by ELISA method. Results: Patient group serum leptin values were found to be significantly higher than the control group serum leptin values (p = 0.001). Patient group serum total carnitine values were found to be significantly lower than the control group (p = 0.001). Moderate persistent group adiponectin and total carnitine values were found to be significantly lower than mild intermittent group (p <0.05). A weak negative correlation was found between leptin and total carnitine, eosinophil, BMI values. A weak negative correlation was found between total carnitine and eosinophil, BMI values. A moderate negative correlation was found between age and leptin, adiponectin, total carnitine values. Conclusions: It suggested that leptin levels increased, adiponectin and total carnitine levels decreased in children with asthma and at the same time the decrease in adiponectin and total carnitine levels may be associated with disease severity.

Anahtar Kelimeler

• Asthma
• leptine
• adiponectine
• carnitine

Astımlı çocuklarda leptin, adiponektin ve karnitin düzeylerinin akciğer fonksiyonları, astım şiddeti ve BMI ile ilişkisinin değerlendirilmesi

Öz

Amaç: Bu çalışmanın amacı astımlı çocuklarda leptin, adiponektin gibi adipokinlerin ve karnitin gibi mediatörlerin serum düzeylerinin akciğer fonksiyonları, hastalık şiddeti ve BMI ile ilişkisini değerlendirmektir. Gereç ve yöntem: Çalışma kapsamına akut atak döneminde olmayan 97 bronşial astımlı çocuk hasta ve 40 sağlıklı kontrol bireyi alındı. Tüm astım hastalarına spirometre ile solunum fonksiyon testleri yapıldı. Astımlı çocuk hastalar hava yolu obstruksiyon şiddetine göre semptomlar ve spirometrik parametreler kullanılarak GINA kriterlerine göre hafif intermittan, hafif persistan, orta persistan 3 gruba ayrıldı. Venöz kandan ELİSA yöntemi ile leptin, total karnitin ve adiponektin analizleri yapıldı. Bulgular: Hasta grubu serum leptin değerleri, kontrol grup serum leptin değerlerinden anlamlı düzeyde yüksek bulundu (p=0.001). Hasta grubu serum total karnitin değerleri kontrol gruuninkinden anlamlı düzeyde düşük bulundu (p=0.001). Orta persistan grup adiponektin ve total karnitin değerleri hafif intermitant gruptan anlamlı düzeyde düşük bulundu (p<0.05). Leptin ve total karnitin değerleri ile eozinofil ve BMI değerleri arasında zayıf negatif korelasyon bulundu. Yaş ile leptin, adiponektin ve total karnitin değerleri arasında orta düzey negatif korelasyon bulundu. Sonuç: Astımlı çocuklarda leptin düzeylerinin arttığını, adiponektin ve total karnitin düzeylerinin azaldığını, adiponektin ve total karnitin düzeylerindeki azalmamın hastalık şiddeti ile ilişkili olabileceğini düşündürdü.

Anahtar Kelimeler

• astım
• leptin
• adiponektin
• karnitin

Kaynakça

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