Öz
Purpose: Some anesthetic drugs are known to have influence on circulation due to hemorheological effects.
We aimed to investigate the possible effects of ketamin-xylazine anesthesia, which is extensively used in
experimental animal laboratories on hemorheological parameters.
Materials and methods: Adult, male Wistar-Albino rats were divided into two as control (pre-anesthesia)
and post-anesthesia (n=17). Ketamin-HCl/Xylazine-HCl (90 mg/kg-10 mg/kg) were injected intraperitoneally.
Intracardiac heparinized blood was collected either without anesthesia (control group) or after anesthesia
(post-anesthesia group) following the loss of reflexes such as righting, cornea and withdrawal. Erythrocyte
deformability was determined by an ektacytometer, while WBV (at shear rates of 38, 76 and 190 s-1) and PV
(at 190 s-1 shear rate) at standard (40%) and otolog hematocrit (Hct) were measured via a cone-plate rotational
viscometer.
Results: Mean time taken for the disappearance of righting reflex was 4±3.6, corneal reflex 8±6.8 and for
withdrawal reflex 10±6.7 min. 90 mg/kg Ketamin-10 mg/kg Xylazine administration did not affect RBC
deformability, WBV and PV of the rats.
Conclusion: These results demonstrate that, use of Ketamin/Xylazine anesthesia may be recommended
especially when dealing with hemorheological, cardiovascular and hematological parameters.
Kaynakça
- Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), Handbook of Hemorheology and Hemodynamics. IOS Press: Netherlands, 2007
- Rampling MW. History of Hemorheology, In: Handbook of Hemorheology and Hemodynamics, Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), IOS Press: Netherlands, 2007
- Sengoz, T., E. Kilic-Toprak, O. Yaylali, O. Kilic-Erkek, Y. Ozdemir, B. Oymak, H. Senol, D. Yuksel, V. Kucukatay, ve M.Bor-Kucukatay, “Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment.” Clin. Hemorheol. Microcirc., 74 (2), 209-221 (2020). https://doi.org/10.3233/CH-190717. PMID: 31884456
- Unver F., E. Kilic-Toprak, O. Kilic-Erkek, H. Korkmaz, O. Yasin, B. Oymak, A. Oskay ve M. Bor-Kucukatay, “Hemorheological alterations following an acute bout of nordic hamstring exercise in active male participants1.” Clin. Hemorheol. Microcirc., 71(4):463-473 (2019) https://doi.org/10.3233/CH-180402.
- Yaylali Y.T., E. Kilic-Toprak, Y. Ozdemir, H. Senol ve M.Bor-Kucukatay, “Impaired Blood Rheology in Pulmonary Arterial Hypertension.” Heart Lung Circ., Jul;28(7):1067-1073 (2019) https://doi.org/10.1016/j.hlc.2018.07.014.
- Lowe GDO, Barbenel JC: Plasma and blood viscosity. In: Lowe GDO (eds.), Clinical Blood Rheology. Boca Raton: FL CRC Press, 1998; 11–44
- Myung J, Park SJ, Lim J, Kim YH, Shin S, Lim CH. Effects of lipopolysaccharide on changes in red blood cells in a mice endotoxemia model. Clin Hemorheol Microcirc. 2016 Oct 5;63(4):305-312. https://doi.org/10.3233/CH-152017
Öz
Akbudak ve ark.’nın “Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor” başlıklı araştırma makalesi ile ilgili bir “Editöre Mektup” yazılarak çalışmayla ilgili bazı eleştirilerde bulunulmuş ve çalışmanın özgün olmadığı iddia edilmiştir. Bu yazı, iddialara cevap verilmesi ve çalışmanın “ÖZGÜN” olduğunun bilimsel kurallara uyularak, gerekli literatür bilgileri sunularak net biçimde ortaya konması amacıyla kaleme alınmıştır.
Kaynakça
- Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), Handbook of Hemorheology and Hemodynamics. IOS Press: Netherlands, 2007
- Rampling MW. History of Hemorheology, In: Handbook of Hemorheology and Hemodynamics, Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), IOS Press: Netherlands, 2007
- Sengoz, T., E. Kilic-Toprak, O. Yaylali, O. Kilic-Erkek, Y. Ozdemir, B. Oymak, H. Senol, D. Yuksel, V. Kucukatay, ve M.Bor-Kucukatay, “Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment.” Clin. Hemorheol. Microcirc., 74 (2), 209-221 (2020). https://doi.org/10.3233/CH-190717. PMID: 31884456
- Unver F., E. Kilic-Toprak, O. Kilic-Erkek, H. Korkmaz, O. Yasin, B. Oymak, A. Oskay ve M. Bor-Kucukatay, “Hemorheological alterations following an acute bout of nordic hamstring exercise in active male participants1.” Clin. Hemorheol. Microcirc., 71(4):463-473 (2019) https://doi.org/10.3233/CH-180402.
- Yaylali Y.T., E. Kilic-Toprak, Y. Ozdemir, H. Senol ve M.Bor-Kucukatay, “Impaired Blood Rheology in Pulmonary Arterial Hypertension.” Heart Lung Circ., Jul;28(7):1067-1073 (2019) https://doi.org/10.1016/j.hlc.2018.07.014.
- Lowe GDO, Barbenel JC: Plasma and blood viscosity. In: Lowe GDO (eds.), Clinical Blood Rheology. Boca Raton: FL CRC Press, 1998; 11–44
- Myung J, Park SJ, Lim J, Kim YH, Shin S, Lim CH. Effects of lipopolysaccharide on changes in red blood cells in a mice endotoxemia model. Clin Hemorheol Microcirc. 2016 Oct 5;63(4):305-312. https://doi.org/10.3233/CH-152017
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Anesteziyoloji |
| Bölüm | Editöre Mektup |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2021 |
| Gönderilme Tarihi | 10 Mayıs 2021 |
| Kabul Tarihi | 27 Mayıs 2021 |
| Yayımlandığı Sayı | Yıl 2021 |
