Yıl 2019, Cilt 12 , Sayı 3, Sayfalar 433 - 443 2019-09-30

The effects of primary tumour location on patients with all stages of colorectal cancer
Kolorektal kanserde primer tümör lokalizasyonunun tüm evrelerdeki etkileri

Esin Oktay [1] , Serkan Değirmencioğlu [2]


Abstract:

Purpose:The aim of this study was to examine the effects of tumor localization in early and advanced stage colon cancer patients.

Materials and Methods :This retrospective study enrolled  249 primary colorectal cancer (CRC) patients at medical oncology department of Adnan Menderes University between 2013-2017.

Results:In early stage, left sided tumors were significantly more common in males(p=0.027). In right sided tumours recurrence developed earlier in female patients(p=0.043) and female sex,young age were unfavorable prognostic factors for the relapse time.  Positive and unknown PANRAS mutation status were found to be unfavorable prognostic factors for both side. In metastatic stage, patients with PANRAS mutant left sided tumors lived longer than PANRAS negative patients(49.0 vs 25.5 months respectively, p <0.001). OS was 11 months and PFS was 1.8 months longer with anti-EGFR agents than anti-VEGFR agents, in right sided tumors.In left sided tumors, there was no difference, only PFS was longer with anti-VEGFR agents(13 months vs 6.3 months). In PANRAS positive patients, OS and PFS were longer with anti-VEGFR treatment in the left side tumors(OS 49.0 months vs 30.6 months PFS, 13.2 months vs 7.2 months, p=0.784).

Conclusions: In our study, the efficacy results of the treatment which was given according to the primary tumor location were not compatible with the literature. Primer tumor location is a transition period for understanding of molecular subtypes at the colon cancer. The on-going studies of genomic differences between right and left sided tumors will able to better clarifying of the biologic explanation of the observed difference.

Amaç: Bu çalışmanın amacı erken ve ileri evre kolon kanseri hastalarında tümör lokalizasyonunun etkilerini incelemektir.

Gereç ve Yöntem: 2013-2017 arasında Adnan Menderes Üniversitesi'nin tıbbi onkoloji bölümüne başvuran  primer kolorektal kanser tanılı hastaları retrospektif olarak taradık ve 249 hastayı çalışmaya dahil ettik.

Bulgular: Erken evrede, sol taraftaki kolorektal kanserler  erkeklerde anlamlı olarak daha yaygındı (p = 0.027). Sağ taraftaki tümörlerde nüks  kadın hastalarda daha erken gelişti (p = 0.043) ve kadın cinsiyet, genç yaş nüks süresi için bağımsız prognostik faktörlerdi. PANRAS pozitif ve bilinmeyen mutasyon durumunun her iki taraftaki tümörler için olumsuz prognostik faktörler olduğu bulundu.

Metastatik evrede, sol taraftaki tümörlerde PANRAS mutant olan hastalar daha uzun süre yaşadılar (sırasıyla 49.0'a 25.5 ay, p <0.001). Birinci basamak tedavide anti-EGFR ajanları alan sağ kolon kanseri hastalarında anti-VEGFR ajanları alanlara göre ortalama yaşam süresi(OS) 11 ay, progresyona kadar geçen süre(PFS) 1.8 ay daha uzundu. Sol kolon  tümörlerinde, ilk basamak tedavide fark yoktu yalnızca PFS anti-VEGFR ajanlarıyla daha uzundu (13 ay vs 6.3 ay ). PANRAS pozitif antiVEGFR tedavisi alan hastalar içinde sol kolon yerleşimli tümörlerde OS ve PFS daha uzundu (OS 49.0 ay - 30.6 ay PFS, 13.2 ay ve 7.2 ay, p = 0.784).

Sonuç: Çalışmamızda primer tümör lokasyonuna göre verilen tedavinin etkinlik sonuçları literatürle uyumlu değildi. Primer tümörün yeri, kolon kanserinde moleküler alt tiplerin anlaşılması için bir geçiş dönemidir. Sağ ve sol taraftaki tümörler arasında genomik farklılıkları araştıran çalışmalar, gözlenen farkın biyolojik açıklamasının daha iyi anlaşılmasını mümkün kılacaktır.

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Birincil Dil en
Konular Onkoloji
Yayımlanma Tarihi Eylül 2019
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-5974-6339
Yazar: Esin Oktay (Sorumlu Yazar)
Kurum: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-1213-2778
Yazar: Serkan Değirmencioğlu
Kurum: FACULTY OF MEDICINE
Ülke: Turkey


Destekleyen Kurum yok
Tarihler

Yayımlanma Tarihi : 30 Eylül 2019

Bibtex @araştırma makalesi { patd567575, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2019}, volume = {12}, pages = {433 - 443}, doi = {10.31362/patd.567575}, title = {The effects of primary tumour location on patients with all stages of colorectal cancer}, key = {cite}, author = {Oktay, Esin and Değirmencioğlu, Serkan} }
APA Oktay, E , Değirmencioğlu, S . (2019). The effects of primary tumour location on patients with all stages of colorectal cancer. Pamukkale Tıp Dergisi , 12 (3) , 433-443 . DOI: 10.31362/patd.567575
MLA Oktay, E , Değirmencioğlu, S . "The effects of primary tumour location on patients with all stages of colorectal cancer". Pamukkale Tıp Dergisi 12 (2019 ): 433-443 <https://dergipark.org.tr/tr/pub/patd/issue/48923/567575>
Chicago Oktay, E , Değirmencioğlu, S . "The effects of primary tumour location on patients with all stages of colorectal cancer". Pamukkale Tıp Dergisi 12 (2019 ): 433-443
RIS TY - JOUR T1 - The effects of primary tumour location on patients with all stages of colorectal cancer AU - Esin Oktay , Serkan Değirmencioğlu Y1 - 2019 PY - 2019 N1 - doi: 10.31362/patd.567575 DO - 10.31362/patd.567575 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 433 EP - 443 VL - 12 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.567575 UR - https://doi.org/10.31362/patd.567575 Y2 - 2019 ER -
EndNote %0 Pamukkale Tıp Dergisi The effects of primary tumour location on patients with all stages of colorectal cancer %A Esin Oktay , Serkan Değirmencioğlu %T The effects of primary tumour location on patients with all stages of colorectal cancer %D 2019 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 12 %N 3 %R doi: 10.31362/patd.567575 %U 10.31362/patd.567575
ISNAD Oktay, Esin , Değirmencioğlu, Serkan . "The effects of primary tumour location on patients with all stages of colorectal cancer". Pamukkale Tıp Dergisi 12 / 3 (Eylül 2019): 433-443 . https://doi.org/10.31362/patd.567575
AMA Oktay E , Değirmencioğlu S . The effects of primary tumour location on patients with all stages of colorectal cancer. Pamukkale Tıp Dergisi. 2019; 12(3): 433-443.
Vancouver Oktay E , Değirmencioğlu S . The effects of primary tumour location on patients with all stages of colorectal cancer. Pamukkale Tıp Dergisi. 2019; 12(3): 443-433.