Yıl 2020, Cilt 13 , Sayı 1, Sayfalar 199 - 206 2020-01-21

Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial
Endometriozisli hastalarda ovulasyon indüksiyonu ajanı olarak letrozol ve gonedotropinlerin karşılaştırılması: prospektif randomize çalışma

Tolga ATAKUL [1] , S.özlem ALTINKAYA [2] , Gökalp ÖNER [3] , Mahmut Tuncay ÖZGÜN [4] , Yılmaz ŞAHİN [5] , Ercan Mustafa AYGEN [6]


Purpose: This study aimed to compare the effects of letrozole and gonadotropins for ovulation induction in infertile patients with stage 1-2 endometriosis.

Materials and methods: Twenty patients who underwent diagnostic laparoscopy and histologically diagnosed stage 1-2 endometriosis were included in this prospective randomized study.   Patients who planned to continue with timed sexual intercourse were randomized into two treatment groups including letrozole (n=10) or gonadotropins (n=10) for minimum three and maximum five treatment cycles.

Results: Ovulation occurred in 37/45 cycles (82.2%) in the letrozole group and 32/37 cycles (86.4%) in the gonadotropin group, without statistically significant difference (p=0.590). Total number of follicles was significantly higher in gonadotropin group on the day of hCG administration (2.33±0.71 vs. 3.05±0.91, p<0.001). Clinical pregnancy rates both per completed cycles and per patients were similar between two groups (8.1% vs. 9.4%, p=0.850 and 30% vs. 30%, p=1.000; respectively).

Conclusions: Letrozole is well tolerated and cost effective ovulation induction agent in patients with endometriosis and effects of letrozole for ovulation induction were comparable to gonadotropins. 

Amaç: Bu çalışmada letrozol ve gonadotropinlerin evre 1-2 endometriozisli infertil hastalarda ovülasyon indüksiyonu üzerine etkilerinin karşılaştırılması amaçlanmıştır.

Gereç ve yöntem: Prospektif randomize olarak dizayn edilen çalışmaya tanısal laparoskopi yapılan ve histolojik olarak tanı konulan evre 1-2 endometriozisli 20 hasta dahil edildi. Zamanlanmış cinsel ilişki ile devam etmeyi planlayan hastalar, en az üç en fazla beş ovulasyon indüksiyonu döngüsü için letrozol (n=10) veya gonadotropinler (n=10) olmak üzere iki tedavi grubuna ardışık olarak randomize edildi.

Bulgular: Ovulasyon, letrozol grubunda %82,2 (37/45 siklus) ve gonadotropin grubunda %86,4 (32/37 siklus) oranlarında gerçekleşti. İki grup arasında ovulasyon oranları istatistiksel olarak benzerdi (p=0,590). hCG uygulamasının yapıldığı gün gonadotropin grubunda toplam folikül sayısı anlamlı olarak yüksekti (2,33±0,71 ve 3,05±0,91, p<0,001). Klinik gebelik oranları hem tamamlanmış siklus başına hem de hasta başına iki grup arasında benzerdi (sırasıyla siklus başına %8,1 ve %9,4  p=0,850 ve hasta başına %30 ve%30, p=1,000).

Sonuç: Letrozol iyi tolere edilebilen bir ovulasyon indüksiyonu ajanıdır.  Evre 1-2 Endometriozisli hastalarda letrozolün ovülasyon indüksiyonu üzerindeki etkileri gonadotropinlerle karşılaştırılabilir bulunmuştur.

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Birincil Dil en
Konular Kadın Hastalıkları ve Doğum
Yayımlanma Tarihi Ocak 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0219-000X
Yazar: Tolga ATAKUL
Kurum: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-0991-7443
Yazar: S.özlem ALTINKAYA (Sorumlu Yazar)
Kurum: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-6270-4340
Yazar: Gökalp ÖNER
Kurum: Kayseri Magnet Hospital
Ülke: Turkey


Orcid: 0000-0003-4946-2268
Yazar: Mahmut Tuncay ÖZGÜN
Kurum: ERCİYES UNIVERSITY FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-3415-8151
Yazar: Yılmaz ŞAHİN
Kurum: ERCİYES UNIVERSITY FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-8677-0940
Yazar: Ercan Mustafa AYGEN
Kurum: ERCİYES UNIVERSITY FACULTY OF MEDICINE
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 21 Ocak 2020

Bibtex @araştırma makalesi { patd548470, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {199 - 206}, doi = {10.31362/patd.548470}, title = {Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial}, key = {cite}, author = {ATAKUL, Tolga and ALTINKAYA, S.özlem and ÖNER, Gökalp and ÖZGÜN, Mahmut Tuncay and ŞAHİN, Yılmaz and AYGEN, Ercan Mustafa} }
APA ATAKUL, T , ALTINKAYA, S , ÖNER, G , ÖZGÜN, M , ŞAHİN, Y , AYGEN, E . (2020). Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial. Pamukkale Tıp Dergisi , 13 (1) , 199-206 . DOI: 10.31362/patd.548470
MLA ATAKUL, T , ALTINKAYA, S , ÖNER, G , ÖZGÜN, M , ŞAHİN, Y , AYGEN, E . "Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial". Pamukkale Tıp Dergisi 13 (2020 ): 199-206 <https://dergipark.org.tr/tr/pub/patd/issue/51998/548470>
Chicago ATAKUL, T , ALTINKAYA, S , ÖNER, G , ÖZGÜN, M , ŞAHİN, Y , AYGEN, E . "Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial". Pamukkale Tıp Dergisi 13 (2020 ): 199-206
RIS TY - JOUR T1 - Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial AU - Tolga ATAKUL , S.özlem ALTINKAYA , Gökalp ÖNER , Mahmut Tuncay ÖZGÜN , Yılmaz ŞAHİN , Ercan Mustafa AYGEN Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.548470 DO - 10.31362/patd.548470 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 199 EP - 206 VL - 13 IS - 1 SN - -1308-0865 M3 - doi: 10.31362/patd.548470 UR - https://doi.org/10.31362/patd.548470 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial %A Tolga ATAKUL , S.özlem ALTINKAYA , Gökalp ÖNER , Mahmut Tuncay ÖZGÜN , Yılmaz ŞAHİN , Ercan Mustafa AYGEN %T Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 1 %R doi: 10.31362/patd.548470 %U 10.31362/patd.548470
ISNAD ATAKUL, Tolga , ALTINKAYA, S.özlem , ÖNER, Gökalp , ÖZGÜN, Mahmut Tuncay , ŞAHİN, Yılmaz , AYGEN, Ercan Mustafa . "Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial". Pamukkale Tıp Dergisi 13 / 1 (Ocak 2020): 199-206 . https://doi.org/10.31362/patd.548470
AMA ATAKUL T , ALTINKAYA S , ÖNER G , ÖZGÜN M , ŞAHİN Y , AYGEN E . Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial. Pamukkale Tıp Dergisi. 2020; 13(1): 199-206.
Vancouver ATAKUL T , ALTINKAYA S , ÖNER G , ÖZGÜN M , ŞAHİN Y , AYGEN E . Letrozole versus gonadotropins for ovulation induction in patients with endometriosis: a prospective randomized trial. Pamukkale Tıp Dergisi. 2020; 13(1): 206-199.