Yıl 2020, Cilt 13 , Sayı 1, Sayfalar 207 - 214 2020-01-21

Fibromyalji klinik ve laboratuar parametreleri ile obezite ilişkisi
Relationship between fibromyalgia clinical and laboratory parameters with obesity

Hülya DEVECİ [1]


           

Amaç: Fibromiyalji sendromu (FMS) yaygın ağrı ile karakterize sık görülen bir hastalıktır. Obezite de sık görülen,  adipoz dokuda aşırı yağ birikimi ile karakterize kompleks bir hastalıktır. Obez bireylerde normal kişilere göre daha fazla kas iskelet sistemi ağrıları olduğu bilinmektedir. Biz de bu çalışmamızda obezite ile fibromyalji klinik ve laboratuar parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Çalışmaya 50 FMS hastası ve 35 sağlıklı kontrol grubu alındı. FMS hastaları VKİ’lerine göre obez (VKİ≥30) ve non-obez (VKİ<30) olarak iki alt gruba ayrıldı. Gruplar arasında Vizual Analog Skalası (VAS), Fibromyalji Etki Anketi (FEA), Kısa Form-36 (KF-36), Beck Depresyon ölçeği (BDÖ) ile klinik olarak, serum CRP, vitamin B12, folat, TSH düzeyleri ile laboratuar olarak karşılaştırmalar yapıldı.

Bulgular: BDÖ, KF-36’nın fiziksel fonksiyon skoru obez grupta non-obez ve sağlıklı kontrol grubuna göre anlamlı olarak daha yüksekti (p<0.001). Parestezi ve dinlendirmeyen uyku semptomları da obez grupta non-obez gruptan anlamlı derecede daha yüksekti (p<0.05). Obez FMS grupta serum vitamin B12 değerleri non-obez FMS gruptan anlamlı düzeyde düşük, serum CRP değerleri ise anlamlı düzeyde yüksek bulundu (sırasıyla p<0.001 ve p<0.05). VAS, ağrı süresi, hassas nokta sayısı, FEA, TSH, folat düzeyleri açısından gruplar arasında istatiksel anlamlı farklılık gözlenmedi.

Sonuç: Obezitenin, FMS’li hastalarda hastalığın patogenez ve prognozuna etkisi olabileceği düşüncesi hakimdir. Bizim çalışmamızdaki bulgular da kısmi olarak literatürdeki FMS-obezite ilişkisini destekler niteliktedir. Bu ilişkinin daha net ortaya konulabilmesi için daha geniş sayıda hasta gruplarını içeren ve daha iyi homojenize edilmiş hasta ve kontrol gruplarının kullanıldığı prospektif çalışmalara ihtiyaç vardır.

 

Anahtar Kelimeler: Fibromyalji, Obezite,Kısa Form-36, Beck Depresyon Ölçeği, Vitamin B12

 

 

Purpose: Fibromyalgia syndrome (FMS) is a common disease characterized by diffuse pain. Obesity is also a common disease characterized by excessive fat accumulation in adipose tissue. Obese individuals are known to have more musculoskeletal pain than normal people. In this study, we aimed to evaluate the relationship between obesity and fibromyalgia clinical and laboratory parameters.

 

Materials and Methods: The study included 50 FMS patients and 35 healthy control groups. FMS patients were divided into two subgroups according to their BMI: obese (BMI≥30) and non-obese (BMI<30). Clinical comparisons were made with Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FEA), Short Form-36 (SF-36), and Beck Depression Inventory (BDI). In addition, serum CRP, vitamin B12, folate, TSH levels were compared.

 

Results: BDI, SF-36 physical function score was significantly higher in the obese group compared to the non-obese and healthy control group (p<0.001). Paresthesia and restless sleep symptoms were also significantly higher in the obese group than the non-obese group (p<0.05). Serum vitamin B12 levels were significantly lower and serum CRP values were significantly higher in the obese FMS group than the non-obese FMS group (p<0.001 and p<0.05, respectively). There was no statistically significant difference between groups in terms of VAS, FIQ score, pain duration, tender point count, serum TSH and folate levels.

 

Conclusion: Obesity is thought to have an impact on the pathogenesis and prognosis of the disease in patients with FMS. The findings of our study support the FMS-obesity relationship in the literature. To clarify this relationship, prospective studies involving more patient groups and using better homogenized patients and control groups are needed.


 

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Birincil Dil en
Konular Romatoloji
Yayımlanma Tarihi Ocak 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-7491-1569
Yazar: Hülya DEVECİ (Sorumlu Yazar)
Kurum: TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 21 Ocak 2020

Bibtex @araştırma makalesi { patd647570, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {207 - 214}, doi = {10.31362/patd.647570}, title = {Relationship between fibromyalgia clinical and laboratory parameters with obesity}, key = {cite}, author = {DEVECİ, Hülya} }
APA DEVECİ, H . (2020). Relationship between fibromyalgia clinical and laboratory parameters with obesity. Pamukkale Tıp Dergisi , 13 (1) , 207-214 . DOI: 10.31362/patd.647570
MLA DEVECİ, H . "Relationship between fibromyalgia clinical and laboratory parameters with obesity". Pamukkale Tıp Dergisi 13 (2020 ): 207-214 <https://dergipark.org.tr/tr/pub/patd/issue/51998/647570>
Chicago DEVECİ, H . "Relationship between fibromyalgia clinical and laboratory parameters with obesity". Pamukkale Tıp Dergisi 13 (2020 ): 207-214
RIS TY - JOUR T1 - Relationship between fibromyalgia clinical and laboratory parameters with obesity AU - Hülya DEVECİ Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.647570 DO - 10.31362/patd.647570 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 207 EP - 214 VL - 13 IS - 1 SN - -1308-0865 M3 - doi: 10.31362/patd.647570 UR - https://doi.org/10.31362/patd.647570 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Relationship between fibromyalgia clinical and laboratory parameters with obesity %A Hülya DEVECİ %T Relationship between fibromyalgia clinical and laboratory parameters with obesity %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 1 %R doi: 10.31362/patd.647570 %U 10.31362/patd.647570
ISNAD DEVECİ, Hülya . "Relationship between fibromyalgia clinical and laboratory parameters with obesity". Pamukkale Tıp Dergisi 13 / 1 (Ocak 2020): 207-214 . https://doi.org/10.31362/patd.647570
AMA DEVECİ H . Relationship between fibromyalgia clinical and laboratory parameters with obesity. Pamukkale Tıp Dergisi. 2020; 13(1): 207-214.
Vancouver DEVECİ H . Relationship between fibromyalgia clinical and laboratory parameters with obesity. Pamukkale Tıp Dergisi. 2020; 13(1): 214-207.