Relationship between fibromyalgia clinical and laboratory parameters with obesity

Öz

Purpose: Fibromyalgia syndrome (FMS) is a common disease characterized by diffuse pain. Obesity is also a common disease characterized by excessive fat accumulation in adipose tissue. Obese individuals are known to have more musculoskeletal pain than normal people. In this study, we aimed to evaluate the relationship between obesity and fibromyalgia clinical and laboratory parameters.

 

Materials and Methods: The study included 50 FMS patients and 35 healthy control groups. FMS patients were divided into two subgroups according to their BMI: obese (BMI≥30) and non-obese (BMI<30). Clinical comparisons were made with Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FEA), Short Form-36 (SF-36), and Beck Depression Inventory (BDI). In addition, serum CRP, vitamin B12, folate, TSH levels were compared.

 

Results: BDI, SF-36 physical function score was significantly higher in the obese group compared to the non-obese and healthy control group (p<0.001). Paresthesia and restless sleep symptoms were also significantly higher in the obese group than the non-obese group (p<0.05). Serum vitamin B12 levels were significantly lower and serum CRP values were significantly higher in the obese FMS group than the non-obese FMS group (p<0.001 and p<0.05, respectively). There was no statistically significant difference between groups in terms of VAS, FIQ score, pain duration, tender point count, serum TSH and folate levels.

 

Conclusion: Obesity is thought to have an impact on the pathogenesis and prognosis of the disease in patients with FMS. The findings of our study support the FMS-obesity relationship in the literature. To clarify this relationship, prospective studies involving more patient groups and using better homogenized patients and control groups are needed.

 

Anahtar Kelimeler

• Fibromyalgia,Obesity,Short Form 36,Beck Depression Inventory,Vitamin B12

Fibromyalji klinik ve laboratuar parametreleri ile obezite ilişkisi

Öz

           

Amaç: Fibromiyalji sendromu (FMS) yaygın ağrı ile karakterize sık görülen bir hastalıktır. Obezite de sık görülen,  adipoz dokuda aşırı yağ birikimi ile karakterize kompleks bir hastalıktır. Obez bireylerde normal kişilere göre daha fazla kas iskelet sistemi ağrıları olduğu bilinmektedir. Biz de bu çalışmamızda obezite ile fibromyalji klinik ve laboratuar parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Çalışmaya 50 FMS hastası ve 35 sağlıklı kontrol grubu alındı. FMS hastaları VKİ’lerine göre obez (VKİ≥30) ve non-obez (VKİ<30) olarak iki alt gruba ayrıldı. Gruplar arasında Vizual Analog Skalası (VAS), Fibromyalji Etki Anketi (FEA), Kısa Form-36 (KF-36), Beck Depresyon ölçeği (BDÖ) ile klinik olarak, serum CRP, vitamin B12, folat, TSH düzeyleri ile laboratuar olarak karşılaştırmalar yapıldı.

Bulgular: BDÖ, KF-36’nın fiziksel fonksiyon skoru obez grupta non-obez ve sağlıklı kontrol grubuna göre anlamlı olarak daha yüksekti (p<0.001). Parestezi ve dinlendirmeyen uyku semptomları da obez grupta non-obez gruptan anlamlı derecede daha yüksekti (p<0.05). Obez FMS grupta serum vitamin B12 değerleri non-obez FMS gruptan anlamlı düzeyde düşük, serum CRP değerleri ise anlamlı düzeyde yüksek bulundu (sırasıyla p<0.001 ve p<0.05). VAS, ağrı süresi, hassas nokta sayısı, FEA, TSH, folat düzeyleri açısından gruplar arasında istatiksel anlamlı farklılık gözlenmedi.

Sonuç: Obezitenin, FMS’li hastalarda hastalığın patogenez ve prognozuna etkisi olabileceği düşüncesi hakimdir. Bizim çalışmamızdaki bulgular da kısmi olarak literatürdeki FMS-obezite ilişkisini destekler niteliktedir. Bu ilişkinin daha net ortaya konulabilmesi için daha geniş sayıda hasta gruplarını içeren ve daha iyi homojenize edilmiş hasta ve kontrol gruplarının kullanıldığı prospektif çalışmalara ihtiyaç vardır.

 

Anahtar Kelimeler: Fibromyalji, Obezite,Kısa Form-36, Beck Depresyon Ölçeği, Vitamin B12

 

 

Anahtar Kelimeler

• Vitamin B12,Fibromyalji,Obezite,Kısa Form 36,Beck Depresyon Ölçeği,Vitamin B12

Kaynakça

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