Yıl 2021, Cilt 14 , Sayı 2, Sayfalar 452 - 459 2021-04-01

Orta şiddette ve şiddetli psoriasis hastalarında ustekinumab tedavisi sonrası inflamatuar belirteçlerde azalma
Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis

Banu TAŞKIN [1] , Bachar MEMET [2] , Eren VURGUN [3] , Sibel ALPER [4]


Giriş: Psoriazis kronik, inflamatuar ve sistemik bir hastalıktır. Psoriaziste hastalık şiddetini ölçmek için Psoriazis Alan Şiddet İndeksi (PAŞİ) yanı sıra daha objektif laboratuar araçlarına ihtiyaç vardır. Nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (TLO), ve oratalama trombosit hacmi (OTH) çeşitli inflamatuar hastalıklarda arttığı bilinen belirteçlerdir. Bu çalışmada amacımız orta şiddette ve şiddetli psoriasis vulgarisi olan hastalarda NLO, TLO ve OTH değerlerinin ustekinumab tedavisi ile değişimlerini araştırmaktır. Gereç ve yöntem: Çalışmada orta şiddette veya şiddetli psoriazis vulgarisi olup, ustekinumab tedavisi verilen kronik plak tipi psoriasis tanılı 25 hasta retrospektif olarak değerlendirilmiştir. Hastaların tedavi öncesi PASI, tam kan sayımı parametreleri, serum CRP seviyeleri ve PAŞİ 75 ve/veya üzeri başarı elde edildikleri kontrollerindeki değerleri kaydedilmiştir. Tam kan sayımı belirteçleri, OTH ve CRP değeri determine edilmiştir. Ek inflamatuar hastalığı ve eşlik eden enfeksiyonu olanlar çalışma dışı bırakılmıştır. Bulgular: Hastaların PASI 75 başarı ve üzeri elde ettikleri incelemelerde NLO, TLO oranlarında istatistiksel olarak anlamlı düşme (p<0.05) saptanırken OTH ve CRP değerlerinde tedavi başarısı sonrası anlamlı değişiklik izlenmemiştir. Tartışma: NLO ve TLO değerlerinde tedavi yanıtı alınmasıyla anlamlı düşme olduğu gösterdik. Bu göstergeler rutin pratikte kolay ölçülebilen ve maliyet açısından verimli belirteçlerdir.
Purpose: Psoriasis is a chronic, inflammatory, and systemic disease. The disease activity is usually measured by Psoriasis Area and Severity Index (PASI), however, further objective laboratory tools are needed. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) are objectively calculated markers that increase in inflammation. This study aimed to investigate the utility of these markers for follow-up of systemic inflammation and response to treatment. Material and methods: A total of 25 patients who had moderate or severe psoriasis vulgaris, who received ustekinumab treatment were retrospectively evaluated in the study. In patients, pre-treatment PASI, complete blood count parameters, serum CRP levels and NLR, PLR and MPV values in the follow up when they achieved PASI 75 and/or more improvement were recorded. Patients with an additional inflammatory disease or accompanying infection were excluded from the study. Results: While a statistically significant decline was recorded in NLR and PLR (p<0.05), no significant change was observed in MPV and CRP after the therapy success where patients achieved an improvement greater than or equal to PASI 75. Conclusion: We conclude that the correlation with the response to treatment and NLR and PLR levels show that these markers may be beneficial for assessment of disease severity either in combination with current scores or alone. These markers are cost effective predictors that can easily be measured in routine practice.
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Birincil Dil en
Konular Dermatoloji
Yayınlanma Tarihi Nisan 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-9651-9258
Yazar: Banu TAŞKIN (Sorumlu Yazar)
Kurum: Koç University Hospital, Department of Dermatology, Istanbul
Ülke: Turkey


Orcid: 0000-0001-7731-943X
Yazar: Bachar MEMET
Kurum: Koç University Hospital, Department of Dermatology, Istanbul
Ülke: Turkey


Orcid: 0000-0002-2288-1123
Yazar: Eren VURGUN
Kurum: Department of Medical Biochemistry, Sorgun State Hospital, Yozgat,
Ülke: Turkey


Orcid: 0000-0001-9086-2250
Yazar: Sibel ALPER
Kurum: Koç University Hospital, Department of Dermatology, Istanbul
Ülke: Turkey


Destekleyen Kurum yok
Proje Numarası yok
Teşekkür yok
Tarihler

Yayımlanma Tarihi : 1 Nisan 2021

Bibtex @araştırma makalesi { patd748871, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {452 - 459}, doi = {10.31362/patd.748871}, title = {Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis}, key = {cite}, author = {Taşkın, Banu and Memet, Bachar and Vurgun, Eren and Alper, Sibel} }
APA Taşkın, B , Memet, B , Vurgun, E , Alper, S . (2021). Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis . Pamukkale Tıp Dergisi , 14 (2) , 452-459 . DOI: 10.31362/patd.748871
MLA Taşkın, B , Memet, B , Vurgun, E , Alper, S . "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis" . Pamukkale Tıp Dergisi 14 (2021 ): 452-459 <https://dergipark.org.tr/tr/pub/patd/issue/60284/748871>
Chicago Taşkın, B , Memet, B , Vurgun, E , Alper, S . "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis". Pamukkale Tıp Dergisi 14 (2021 ): 452-459
RIS TY - JOUR T1 - Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis AU - Banu Taşkın , Bachar Memet , Eren Vurgun , Sibel Alper Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.748871 DO - 10.31362/patd.748871 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 452 EP - 459 VL - 14 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.748871 UR - https://doi.org/10.31362/patd.748871 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis %A Banu Taşkın , Bachar Memet , Eren Vurgun , Sibel Alper %T Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 2 %R doi: 10.31362/patd.748871 %U 10.31362/patd.748871
ISNAD Taşkın, Banu , Memet, Bachar , Vurgun, Eren , Alper, Sibel . "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis". Pamukkale Tıp Dergisi 14 / 2 (Nisan 2021): 452-459 . https://doi.org/10.31362/patd.748871
AMA Taşkın B , Memet B , Vurgun E , Alper S . Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pam Tıp Derg. 2021; 14(2): 452-459.
Vancouver Taşkın B , Memet B , Vurgun E , Alper S . Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis. Pamukkale Tıp Dergisi. 2021; 14(2): 452-459.
IEEE B. Taşkın , B. Memet , E. Vurgun ve S. Alper , "Decrease in inflammation markers with ustekinumab treatment in moderate-severe psoriasis", Pamukkale Tıp Dergisi, c. 14, sayı. 2, ss. 452-459, Nis. 2021, doi:10.31362/patd.748871