Yıl 2021, Cilt 14 , Sayı 2, Sayfalar 322 - 329 2021-04-01

Myelofibrozis hastalarında Ruxolitinib kullanımı: tek merkez deneyimi ve JAK-2 allel yükü ile Ruxolitinib yanıtı arasındaki ilişki
Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response

Mesut GÖÇER [1] , Erdal KURTOĞLU [2]


Abstract: Purpose: Ruxolitinib is an oral JAK-1/2 inhibitor approved for the treatment of splenomegaly and/or constitutional symptoms in intermediate and high-risk myelofibrosis patients. The aim of our study is to evaluate the efficacy and safety of ruxolitinib in primary MF, post-ET MF and post-PV MF patients, to evaluate the relationship between response and JAK-2 mutation rate and to compare them with literature data. Materials and Methods: In our single centered and retrospective study, we investigated the data of 30 MF patients diagnosed in our clinic between May 2015 and December 2019. We reported demographic features, laboratory values, and spleen sizes. Results: 18 patients (60%) with a median age of 67.5 (45-78) had primary myelofibrosis. Spleen sizes decreased significantly 3 and 6 months after treatment. Constitutional symptoms have disappeared in 28 patients (93.3%). No association was found between JAK-2 mutation rate and treatment response success. Conclusion: Ruxolitinib MF is very safe and effective to relieve constitutional symptoms and decrease spleen size. Despite JAK-2 inhibition, no linear relationship was found between JAK-2 mutation rate and treatment efficacy.
Purpose: Ruxolitinib is an oral JAK-1/2 inhibitor approved for the treatment of splenomegaly and/or constitutional symptoms in intermediate and high-risk myelofibrosis patients. The aim of our study is to evaluate the efficacy and safety of ruxolitinib in primary MF, post-ET MF and post-PV MF patients, to evaluate the relationship between response and JAK-2 mutation rate and to compare them with literature data. Materials and Methods: In our single centered and retrospective study, we investigated the data of 30 MF patients diagnosed in our clinic between May 2015 and December 2019. We reported demographic features, laboratory values, and spleen sizes. Results: 18 patients (60%) with a median age of 67.5 (45-78) had primary myelofibrosis. Spleen sizes decreased significantly 3 and 6 months after treatment. Constitutional symptoms have disappeared in 28 patients (93.3%). No association was found between JAK-2 mutation rate and treatment response success. Conclusion: Ruxolitinib MF is very safe and effective to relieve constitutional symptoms and decrease spleen size. Despite JAK-2 inhibition, no linear relationship was found between JAK-2 mutation rate and treatment efficacy.
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Birincil Dil en
Konular Hematoloji
Yayınlanma Tarihi Nisan 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0346-7154
Yazar: Mesut GÖÇER (Sorumlu Yazar)
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANTALYA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey


Orcid: 0000-0002-6867-6053
Yazar: Erdal KURTOĞLU
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANTALYA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Nisan 2021

Bibtex @araştırma makalesi { patd770631, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {322 - 329}, doi = {10.31362/patd.770631}, title = {Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response}, key = {cite}, author = {Göçer, Mesut and Kurtoğlu, Erdal} }
APA Göçer, M , Kurtoğlu, E . (2021). Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response . Pamukkale Tıp Dergisi , 14 (2) , 322-329 . DOI: 10.31362/patd.770631
MLA Göçer, M , Kurtoğlu, E . "Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response" . Pamukkale Tıp Dergisi 14 (2021 ): 322-329 <https://dergipark.org.tr/tr/pub/patd/issue/60284/770631>
Chicago Göçer, M , Kurtoğlu, E . "Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response". Pamukkale Tıp Dergisi 14 (2021 ): 322-329
RIS TY - JOUR T1 - Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response AU - Mesut Göçer , Erdal Kurtoğlu Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.770631 DO - 10.31362/patd.770631 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 322 EP - 329 VL - 14 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.770631 UR - https://doi.org/10.31362/patd.770631 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response %A Mesut Göçer , Erdal Kurtoğlu %T Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 2 %R doi: 10.31362/patd.770631 %U 10.31362/patd.770631
ISNAD Göçer, Mesut , Kurtoğlu, Erdal . "Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response". Pamukkale Tıp Dergisi 14 / 2 (Nisan 2021): 322-329 . https://doi.org/10.31362/patd.770631
AMA Göçer M , Kurtoğlu E . Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response. Pam Tıp Derg. 2021; 14(2): 322-329.
Vancouver Göçer M , Kurtoğlu E . Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response. Pamukkale Tıp Dergisi. 2021; 14(2): 322-329.
IEEE M. Göçer ve E. Kurtoğlu , "Ruxolitinib use in myelofibrosis patients: the single center experience and the relationship between JAK-2 allele burden and Ruxolitinib response", Pamukkale Tıp Dergisi, c. 14, sayı. 2, ss. 322-329, Nis. 2021, doi:10.31362/patd.770631