Yıl 2021, Cilt 14 , Sayı 2, Sayfalar 444 - 450 2021-04-01

Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor
Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report

İlknur Hatice AKBUDAK [1] , Özgen KILIÇ ERKEK [2] , Egem TUZCU [3] , Hilmiye PAKYÜREK [4] , Z. Melek BOR KÜÇÜKATAY [5]


Amaç: Bazı anestezik ilaçların hemoreolojik etkileri nedeniyle dolaşımı etkilediği bilinmektedir. Deney hayvan laboratuarlarında yaygın olarak kullanılan ketamin-ksilazin anestezisinin hemoreolojik parametreler üzerine olası etkilerini araştırmayı amaçladık. Gereç ve yöntem: Yetişkin, erkek Wistar-Albino sıçanlar kontrol (anestezi öncesi) ve anestezi sonrası (n = 17) olarak ikiye ayrıldı. Ketamin-HCl / Xylazine-HCl (90 mg / kg-10 mg / kg) intraperitoneal olarak enjekte edildi. İntrakardiyak heparinize kan anestezi olmadan alındı ​​(kontrol grubu) veya anestezi sonrası (anestezi sonrası grup) düzeltme, kornea ve geri çekme gibi reflekslerin kaybını takiben. Eritrosit deformabilitesi bir ektasitometre ile belirlendi, WBV ise (38, 76 ve 190 s – 1 kesme hızlarında) ve PV (190 sn – 1 kesme hızında) standartta (% 40) ve otolog hematokrit (Hct) bir koni plakalı rotasyonel viskometre ile ölçülmüştür. Bulgular: Doğrultma refleksinin kaybolması için alınan ortalama süre 4 ± 3.6, kornea refleksi 8 ± 6.8 ve geri çekilme refleksi 10 ± 6.7 dakika idi. 90 mg / kg Ketamin-10 mg / kg Xylazine uygulaması, sıçanların RBC deforme olabilirliğini, WBV ve PV'sini etkilememiştir. Sonuç: Bu sonuçlar, Ketamin / Xylazine anestezisinin özellikle hemoreolojik, kardiyovasküler ve hematolojik parametrelerle uğraşırken önerilebileceğini göstermektedir.
Purpose: Some anesthetic drugs are known to have influence on circulation due to hemorheological effects. We aimed to investigate the possible effects of ketamin-xylazine anesthesia, which is extensively used in experimental animal laboratories on hemorheological parameters. Materials and methods: Adult, male Wistar-Albino rats were divided into two as control (pre-anesthesia) and post-anesthesia (n=17). Ketamin-HCl/Xylazine-HCl (90 mg/kg-10 mg/kg) were injected intraperitoneally. Intracardiac heparinized blood was collected either without anesthesia (control group) or after anesthesia (post-anesthesia group) following the loss of reflexes such as righting, cornea and withdrawal. Erythrocyte deformability was determined by an ektacytometer, while WBV (at shear rates of 38, 76 and 190 s–1) and PV (at 190 s–1 shear rate) at standard (40%) and otolog hematocrit (Hct) were measured via a cone-plate rotational viscometer. Results: Mean time taken for the disappearance of righting reflex was 4 ± 3.6, corneal reflex 8 ± 6.8 and for withdrawal reflex 10 ± 6.7 min. 90 mg/kg Ketamin-10 mg/kg Xylazine administration did not affect RBC deformability, WBV and PV of the rats. Conclusion: These results demonstrate that, use of Ketamin/Xylazine anesthesia may be recommended especially when dealing with hemorheological, cardiovascular and hematological parameters.
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Birincil Dil en
Konular Anestezi, Fizyoloji
Yayınlanma Tarihi Nisan 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-9937-9169
Yazar: İlknur Hatice AKBUDAK (Sorumlu Yazar)
Kurum: PAU. Tıp Fakültesi Anestezi ve Reanimasyon
Ülke: Turkey


Orcid: 0000-0001-8037-099X
Yazar: Özgen KILIÇ ERKEK
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0002-9499-2316
Yazar: Egem TUZCU
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0002-7084-3770
Yazar: Hilmiye PAKYÜREK
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0002-9366-0205
Yazar: Z. Melek BOR KÜÇÜKATAY
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Nisan 2021

Bibtex @araştırma makalesi { patd839939, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {444 - 450}, doi = {10.31362/patd.839939}, title = {Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report}, key = {cite}, author = {Akbudak, İlknur Hatice and Kılıç Erkek, Özgen and Tuzcu, Egem and Pakyürek, Hilmiye and Bor Küçükatay, Z. Melek} }
APA Akbudak, İ , Kılıç Erkek, Ö , Tuzcu, E , Pakyürek, H , Bor Küçükatay, Z . (2021). Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report . Pamukkale Tıp Dergisi , 14 (2) , 444-450 . DOI: 10.31362/patd.839939
MLA Akbudak, İ , Kılıç Erkek, Ö , Tuzcu, E , Pakyürek, H , Bor Küçükatay, Z . "Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report" . Pamukkale Tıp Dergisi 14 (2021 ): 444-450 <https://dergipark.org.tr/tr/pub/patd/issue/60284/839939>
Chicago Akbudak, İ , Kılıç Erkek, Ö , Tuzcu, E , Pakyürek, H , Bor Küçükatay, Z . "Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report". Pamukkale Tıp Dergisi 14 (2021 ): 444-450
RIS TY - JOUR T1 - Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report AU - İlknur Hatice Akbudak , Özgen Kılıç Erkek , Egem Tuzcu , Hilmiye Pakyürek , Z. Melek Bor Küçükatay Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.839939 DO - 10.31362/patd.839939 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 444 EP - 450 VL - 14 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.839939 UR - https://doi.org/10.31362/patd.839939 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report %A İlknur Hatice Akbudak , Özgen Kılıç Erkek , Egem Tuzcu , Hilmiye Pakyürek , Z. Melek Bor Küçükatay %T Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 2 %R doi: 10.31362/patd.839939 %U 10.31362/patd.839939
ISNAD Akbudak, İlknur Hatice , Kılıç Erkek, Özgen , Tuzcu, Egem , Pakyürek, Hilmiye , Bor Küçükatay, Z. Melek . "Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report". Pamukkale Tıp Dergisi 14 / 2 (Nisan 2021): 444-450 . https://doi.org/10.31362/patd.839939
AMA Akbudak İ , Kılıç Erkek Ö , Tuzcu E , Pakyürek H , Bor Küçükatay Z . Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report. Pam Tıp Derg. 2021; 14(2): 444-450.
Vancouver Akbudak İ , Kılıç Erkek Ö , Tuzcu E , Pakyürek H , Bor Küçükatay Z . Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report. Pamukkale Tıp Dergisi. 2021; 14(2): 444-450.
IEEE İ. Akbudak , Ö. Kılıç Erkek , E. Tuzcu , H. Pakyürek ve Z. Bor Küçükatay , "Ketamıne/xylazine anesthesia ıs safe in hemorheological point of view: a preliminary report", Pamukkale Tıp Dergisi, c. 14, sayı. 2, ss. 444-450, Nis. 2021, doi:10.31362/patd.839939