COVID-19 pnömonisi ile ilişkili uygunsuz antidiüretik hormon salınım sendromu olgusu

Yıl 2021, Cilt: 14 Sayı: 3, 768 - 773, 01.07.2021

Fethiye Akgül , Pınar Atabey , Eren Zileligil

https://doi.org/10.31362/patd.813814

Öz

Uygunsuz antidiüretik hormon salınım sendromu (UADHSS), hastanede yatan hastalarda hiponatreminin en sık nedenlerinden biridir. Hiponatreminin etiyolojisinde birçok neden olmasından dolayı sebebinin bulunup  tedavi edilmesinde güçlük yaşanabilmektedir. UADHSS’a neden olabilecek birçok infeksiyon hastalığı bildirilmiştir. Bununla birlikte Koronavirüs 2019 hastalığı (COVID-19) ile ilişkili hiponatremi ve UADHSS son zamanlarda birkaç olgu raporunda belirtilmiştir. Bizim olgumuzda ise ilk hastaneye başvuru sırasında COVID-19 pnömonisinin klasik semptomları olan öksürük, nefes darlığı ve ateş şikayeti, ikinci başvurusunda ise hiponatreminin klinik semptomlarından olan halsizlik, genel durum bozukluğu görülmekteydi. COVID-19 olan bir hastada hiponatremi ve UADHSS’nın görülebileceğini vurgulamayı amaçladık.

Anahtar Kelimeler

COVİD-19, hiponatremi, UADHSS

Destekleyen Kurum

Destekleyen herhangi bir kurum yoktur..

A case with the syndrome of inappropriate antidiuretic hormone secretion associated with COVID-19 pneumonia

Öz

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hyponatremia in hospitalized patients. Since there are several etiologies of hyponatremia, it may be difficult to identify and treat the etiology. Several infectious diseases have been reported to cause SIADH. However, hyponatremia and SIADH induced by Coronavirus 2019 disease (COVID-19) have been reported in several recent case reports. However, our case admitted to hospital with the classic symptoms of COVID-19 pneumonia including cough, dyspnea and fever at his first admission, and with the clinical symptoms of hyponatremia, including weakness and general condition disorderat his second admission. Our aim is to emphasize that hyponatremia and SIADHmay be observed in our COVID-19 patient.

Anahtar Kelimeler

COVİD-19, hyponatremia, SIADH

Kaynakça

• Referans1 Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 2020; 395:507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
• Referans2 Türkiye Cumhuriyeti Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü, Covıd-19 (2019-N Cov Hastalığı) Rehberi, Bilim Kurulu Çalışması, 1 Haziran 2020. Erişebilirlik: (erişim: 02.10.2020), https://covid19.saglik.gov.tr/Eklenti/37702/0/covid-19rehberiantisitokin-antiinflamatuartedavilerkoagulopatiyonetimipdf.pdf.
• Referans3 Hong XW, Chi ZP, Liu GY, et al. Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection. MedRxiv 2020. https://doi.org/10.1101/2020.03.07.20032599
• Referans4 Aggarwal S, Garcia-Telles N, Aggarwal G, Lavie C, Lippi G, l Henry BM. Clinical features,laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States. Diagnosis 2020;7:91-96. https://doi.org/10.1515/dx-2020-0046
• Referans5 Corona G, Giuliani C, Parenti G, et al. Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PloS one, 8, e80451. https://doi.org/10.1371/journal.pone.0080451
• Referans6 Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness and attention deficits. Am J Med 2006;119:1-8. https://doi.org/10.1016/j.amjmed.2005.09.026
• Referans7 Ellison DH, Berl T. The syndrome of inappropriate antidiuresis . New England Journal of Medicine 2007;356:2064-2072. DOI: 10.1056/NEJMcp066837
• Referans8 Gaglani B, Gupta S, Chavez O, Libardo R. Influenza as a cause of SIADH related hyponatremia: a case report. J Clin Diagn Res. 2017;11:10-11. doi: 10.7860/JCDR/2017/25785.9797
• Referans9 Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression.The Lancet. 2020;395:1033-1034. doi: 10.1016/S0140-6736(20)30628-0
• Referans10 Park SJ, Shin JI. Inflammation and hyponatremia: an underrecognized condition?. Korean J Pediatr. 2013;56:519-522. doi: 10.3345/kjp.2013.56.12.519
• Referans11 Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020;71:762-768. DOI: 10.1093/cid/ciaa248
• Referans12 Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrology Dialysis Transplantation 2014;29:1-39. doi: 10.1093/ndt/gfu040.
• Referans13 Uslu N, Sinangil A, Çelik A, Ecder T. Hiponatremiye güncel yaklaşım. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2016;2,63-68.