Yıl 2021, Cilt 14 , Sayı 3, Sayfalar 748 - 759 2021-07-01

İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi
Evaluation of factors influencing pregnancy success rate in infertile women who underwent intracytoplasmic sperm injection (ICSI)

Ümit ÇABUŞ [1] , Nazlı ÇİL [2] , Cihan KABUKÇU [3]


Amaç: Çalışmamızın amacı, yardımcı üreme tekniği olarak intrasitoplazmik sperm enjeksiyonu uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesidir. Gereç ve yöntem: Ocak 2018 ve Aralık 2020 tarihleri arasında, intrasitoplazmik sperm enjeksiyonu uygulanan, tek ve taze embriyo transferinin yapıldığı toplam 283 infertil hastaya ait 325 siklus çalışmaya dâhil edildi. Hastaların yaşı, vücut kitle indeksleri, infertilite nedenleri, kaç adet oosit toplandığı ve maturasyon oranı, embriyo transfer günü endometriyal kalınlık, embriyonun kalitesi ve kaçıncı gün transfer edildiği belirlendi. Ayrıca hastaların Anti-Müllerian Hormon (AMH), bazal FSH, LH, estradiol (E2) düzeyleri, Human Chorionic Gonadotropin (hCG) uygulandığı gün E2 ile progesteron (P) düzeyleri ve gebelik sonuçları değerlendirildi. Bulgular: Gebelik oluşan sikluslarda (n:141), oluşmayan sikluslara (n:184) kıyasla kadın yaşı (p=0,015), bazal FSH seviyesi (p=0,005), AMH (p=0,002), elde edilen oosit sayısı (p=0,003), MII oosit sayısı (p=0,001 ), embriyo kalitesi (p<0,001 ) ve 5. gün embriyo transfer oranı (p<0,0001 ) istatiksel olarak anlamlı bulundu. VKİ (p=0,814), bazal E2 seviyesi (p=0,411), hCG günü E2 (p=0,056) ve P seviyesi (p=0,119), ET günü EMK (p=0,146), oosit maturasyon indeksi (p=0,140) ve total pogressif motil sperm sayısı (p=0,747) açısından her iki grup arasında anlamlı bir farklılık gözlenmedi. İnfertilite nedenlerinin gebelik oluşumuna etkisi değerlendirildiğinde gruplar arasında anlamlı fark olmadığı izlendi. Sonuç: ICSI uygulanan infertil kadınlarda gebelik başarısını öngörmede en önemli prognostik faktörler maternal yaş, embriyo kalitesi ve transfer günüdür.
Purpose: The aim of our study is to evaluate the factors affecting pregnancy success rate in infertile women who underwent intracytoplasmic sperm injection as an assisted reproductive technique. Materials and methods: Between January 2018 and December 2020, 325 cycles of 283 infertile patients who underwent intracytoplasmic sperm injection and a single fresh embryo transfer were included in the study. Age of patients, BMI, causes of infertility, number of collected oocytes and maturation rate, endometrial thickness on embryo transfer day, quality of embryo and transfer day were determined. In addition, anti-Müllerian Hormone, basal FSH, LH, estradiol (E2) levels and E2 and progesterone (P) levels on the day of Human Chorionic Gonadotropin (hCG) administration and pregnancy outcomes were evaluated. Results: Age of women (p=0.015), basal FSH level (p=0.005), AMH (p=0.002), number of oocytes obtained (p=0.003), number of MII oocytes (p=0.001), embryo quality (p<0.001) and embryo transfer rate on fifth day (p<0.0001) were found to be statistically significant in cycles resulting in a pregnancy (n:141) compared to nonsuccesful cycles (n:184). BMI (p=0.814), basal E2 level (p=0.411), E2 (p=0.056) and P (p=0.119) levels on hCG day, EMT (p=0.146) on ET day, oocyte maturation index (p=0.140) and total progressive motile sperm count (p=0.747) were not significantly different between the groups. When the effects of infertility causes on pregnancy succes rate were evaluated, there was no significant differences between the groups. Conclusion: The most important prognostic factors in predicting pregnancy success rate in infertile women who underwent ICSI are maternal age, embryo quality and transfer day.
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Birincil Dil tr
Konular Kadın Hastalıkları ve Doğum
Yayınlanma Tarihi Temmuz 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-5478-5673
Yazar: Ümit ÇABUŞ (Sorumlu Yazar)
Kurum: Pamukkale Üniversitesi Tıp Fakültesi, Kadın Hastalıkları Doğum AD
Ülke: Turkey


Orcid: 0000-0002-2164-8688
Yazar: Nazlı ÇİL
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0003-3331-5714
Yazar: Cihan KABUKÇU
Kurum: PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Teşekkür Pamukkale Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum AD, Histoloji ve Embriyoloji AD ve Yardımcı Üreme Teknikleri Merkezinde çalışan başta Prof. Dr. Babür Kaleli, Prof. Dr. S. Erkan Alataş, Prof. Dr. İ. Veysel Fenkçi ve Prof. Dr. Gülçin Mete hocalarımız olmak üzere tüm çalışma arkadaşlarımıza teşekkür ederiz.
Tarihler

Yayımlanma Tarihi : 1 Temmuz 2021

Bibtex @araştırma makalesi { patd899781, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {748 - 759}, doi = {10.31362/patd.899781}, title = {İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi}, key = {cite}, author = {Çabuş, Ümit and Çil, Nazlı and Kabukçu, Cihan} }
APA Çabuş, Ü , Çil, N , Kabukçu, C . (2021). İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi . Pamukkale Tıp Dergisi , 14 (3) , 748-759 . DOI: 10.31362/patd.899781
MLA Çabuş, Ü , Çil, N , Kabukçu, C . "İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi" . Pamukkale Tıp Dergisi 14 (2021 ): 748-759 <https://dergipark.org.tr/tr/pub/patd/issue/61233/899781>
Chicago Çabuş, Ü , Çil, N , Kabukçu, C . "İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi". Pamukkale Tıp Dergisi 14 (2021 ): 748-759
RIS TY - JOUR T1 - İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi AU - Ümit Çabuş , Nazlı Çil , Cihan Kabukçu Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.899781 DO - 10.31362/patd.899781 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 748 EP - 759 VL - 14 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.899781 UR - https://doi.org/10.31362/patd.899781 Y2 - 2021 ER -
EndNote %0 Pamukkale Tıp Dergisi İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi %A Ümit Çabuş , Nazlı Çil , Cihan Kabukçu %T İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 3 %R doi: 10.31362/patd.899781 %U 10.31362/patd.899781
ISNAD Çabuş, Ümit , Çil, Nazlı , Kabukçu, Cihan . "İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi". Pamukkale Tıp Dergisi 14 / 3 (Temmuz 2021): 748-759 . https://doi.org/10.31362/patd.899781
AMA Çabuş Ü , Çil N , Kabukçu C . İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi. Pam Tıp Derg. 2021; 14(3): 748-759.
Vancouver Çabuş Ü , Çil N , Kabukçu C . İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi. Pamukkale Tıp Dergisi. 2021; 14(3): 748-759.
IEEE Ü. Çabuş , N. Çil ve C. Kabukçu , "İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi", Pamukkale Tıp Dergisi, c. 14, sayı. 3, ss. 748-759, Tem. 2021, doi:10.31362/patd.899781