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Uzamış nötropenili COVID-19 vakası

Yıl 2022, Cilt 15, Sayı 2, 391 - 394, 01.04.2022
https://doi.org/10.31362/patd.1017368

Öz

Bu yazıda sağlıklı bir erişkinde COVID-19 enfeksiyonu sırasında gelişen ve yaklaşık 1,5 ay devam eden nötropeni tablosunun takip ve tedavi sürecini sunuyoruz. Halsizlik ve eklem ağrısı şikayeti ile başvurusunda pcr pozitifliği ve laboratuvar incelemesinde nötropeni, lenfopeni saptanması ile COVID-19 tedavisi devam ederken nötropeni için ek medikal tedavi verilmesi açısından değerlendirilen hastaya sekonder enfeksiyonların gelişimini önlemek amacıyla G-CSF tedavisi başlandı. Yaklaşık 1,5 ay devam eden nötropeni durumu 1,5 ayın sonunda tamamen normale döndüğü görüldü. Sağlıklı erişkinde COVID-19 enfeksiyonuna sekonder nötropeni görülebilmektedir ve tedavide G-CSF kullanımının yararlı olacağı düşünülmektedir.

Kaynakça

  • References [1] Aydoğdu S, Celik A, Karakas Z. Nötropeniye yaklaşım. J Child 2015; 15(1):3-9.
  • [2] Husain EH, Mullah-Ali A, Al-Sharidah S, Azab AF, Adekile A. Infectious etiologies of transient neutropenia in previously healthy children.. Pediatr Infect Dis J. 2012;31:575–577.
  • [3] Sloand E. Hematologic complications of HIV infection. AIDS Rev. 2005;7:187–196.
  • [4] Pourbagheri-Sigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in COVID-19 diagnosis and prognosis. Clin Chim Acta. 2020 Nov; 510: 475–482.
  • [5] Singh N, Lubana SS, Dabrowski L. Isolated Chronic and Transient Neutropenia. Cureus 2019 Sep 10;11(9):e5616.
  • [6] Newburger PE, Dale DC. Evaluation and management of patients with isolated neutropenia. Semin Hematol. 2013;50:198–206.
  • [7] Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M. Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis. Cytometry A. 2020 Aug;97(8):772-776.
  • [8] Celkan T, Şirin Koç B. Approach to the patient with neutropenia in childhood. Turk Pediatri Ars 2015 Sep 1;50(3):136-44.
  • [9] Vehreschild JJ, Böhme A, Cornely OA, Kahl C, Karthaus M, Kreuzer KA, Maschmeyer G, Mousset S, Ossendorf V, Penack O, Vehreschild MJGT, Bohlius J. Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy-evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). Ann Oncol 2014 Sep;25(9):1709-1718.
  • [10] Antonino C. Tralongo , Marco Danova. Granulocyte colony-stimulating factors (G-CSF) and COVID-19: a double-edged sword? Infez Med. 2020 Sep 1;28(3):459-460.
  • [11] Potey PMD, Rossi AG, Lucas CD, Dorward DA. Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential. J. Pathol. 2019;247:672–685.
  • [12] Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J. Heart Lung Transplant. 2020;39:405–407.
  • [13] Frederick M. Lang, Kevin M.-C. Lee, John R. Teijaro, Burkhard Becher, and John A. Hamilton. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches. Nat Rev Immunol. 2020 Jun 23 : 1–8.

COVID-19 case with prolonged neutropenia

Yıl 2022, Cilt 15, Sayı 2, 391 - 394, 01.04.2022
https://doi.org/10.31362/patd.1017368

Öz

In this article, we present the follow-up and treatment process of neutropenia, which develops during COVID-19 infection in a healthy adult and lasts for approximately 45 days. When the patient applied with the complaints of weakness and joint pain, the PCR test was positive and neutropenia and lymphopenia were detected in the laboratory examination. Granulocyte-Colony Stimulating Factor (G-CSF) treatment was started in order to prevent the development of secondary infection to the patient, who was evaluated for additional medical treatment for neutropenia while the COVID-19 treatment was continuing. However, it was observed that neutropenia returned to normal after 1.5 months. Neutropenia secondary to COVID-19 infection can be seen in healthy adults and it is thought that the use of G-CSF in the treatment will be beneficial.

Kaynakça

  • References [1] Aydoğdu S, Celik A, Karakas Z. Nötropeniye yaklaşım. J Child 2015; 15(1):3-9.
  • [2] Husain EH, Mullah-Ali A, Al-Sharidah S, Azab AF, Adekile A. Infectious etiologies of transient neutropenia in previously healthy children.. Pediatr Infect Dis J. 2012;31:575–577.
  • [3] Sloand E. Hematologic complications of HIV infection. AIDS Rev. 2005;7:187–196.
  • [4] Pourbagheri-Sigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in COVID-19 diagnosis and prognosis. Clin Chim Acta. 2020 Nov; 510: 475–482.
  • [5] Singh N, Lubana SS, Dabrowski L. Isolated Chronic and Transient Neutropenia. Cureus 2019 Sep 10;11(9):e5616.
  • [6] Newburger PE, Dale DC. Evaluation and management of patients with isolated neutropenia. Semin Hematol. 2013;50:198–206.
  • [7] Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M. Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis. Cytometry A. 2020 Aug;97(8):772-776.
  • [8] Celkan T, Şirin Koç B. Approach to the patient with neutropenia in childhood. Turk Pediatri Ars 2015 Sep 1;50(3):136-44.
  • [9] Vehreschild JJ, Böhme A, Cornely OA, Kahl C, Karthaus M, Kreuzer KA, Maschmeyer G, Mousset S, Ossendorf V, Penack O, Vehreschild MJGT, Bohlius J. Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy-evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). Ann Oncol 2014 Sep;25(9):1709-1718.
  • [10] Antonino C. Tralongo , Marco Danova. Granulocyte colony-stimulating factors (G-CSF) and COVID-19: a double-edged sword? Infez Med. 2020 Sep 1;28(3):459-460.
  • [11] Potey PMD, Rossi AG, Lucas CD, Dorward DA. Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential. J. Pathol. 2019;247:672–685.
  • [12] Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J. Heart Lung Transplant. 2020;39:405–407.
  • [13] Frederick M. Lang, Kevin M.-C. Lee, John R. Teijaro, Burkhard Becher, and John A. Hamilton. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches. Nat Rev Immunol. 2020 Jun 23 : 1–8.

Ayrıntılar

Birincil Dil İngilizce
Konular Genel ve Dahili Tıp
Yayınlanma Tarihi Nisan 2022
Bölüm Olgu Sunumu
Yazarlar

Nilüfer YİĞİT (Sorumlu Yazar)
PAMUKKALE ÜNİVERSİTESİ
0000-0002-5871-6461
Türkiye


Başak ÜNVER KOLUMAN
PAMUKKALE ÜNİVERSİTESİ
0000-0003-1106-5021
Türkiye


Erhan UGURLU
PAMUKKALE ÜNİVERSİTESİ
0000-0001-5402-6925
Türkiye


Göksel ALTINIŞIK ERGUR
PAMUKKALE ÜNİVERSİTESİ
0000-0001-6869-1301
Türkiye

Yayımlanma Tarihi 1 Nisan 2022
Kabul Tarihi 31 Ocak 2022
Yayınlandığı Sayı Yıl 2022, Cilt 15, Sayı 2

Kaynak Göster

Bibtex @olgu sunumu { patd1017368, journal = {Pamukkale Tıp Dergisi}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2022}, volume = {15}, number = {2}, pages = {391 - 394}, doi = {10.31362/patd.1017368}, title = {COVID-19 case with prolonged neutropenia}, key = {cite}, author = {Yiğit, Nilüfer and Ünver Koluman, Başak and Ugurlu, Erhan and Altınışık Ergur, Göksel} }
APA Yiğit, N. , Ünver Koluman, B. , Ugurlu, E. & Altınışık Ergur, G. (2022). COVID-19 case with prolonged neutropenia . Pamukkale Tıp Dergisi , 15 (2) , 391-394 . DOI: 10.31362/patd.1017368
MLA Yiğit, N. , Ünver Koluman, B. , Ugurlu, E. , Altınışık Ergur, G. "COVID-19 case with prolonged neutropenia" . Pamukkale Tıp Dergisi 15 (2022 ): 391-394 <https://dergipark.org.tr/tr/pub/patd/issue/65532/1017368>
Chicago Yiğit, N. , Ünver Koluman, B. , Ugurlu, E. , Altınışık Ergur, G. "COVID-19 case with prolonged neutropenia". Pamukkale Tıp Dergisi 15 (2022 ): 391-394
RIS TY - JOUR T1 - COVID-19 case with prolonged neutropenia AU - Nilüfer Yiğit , Başak Ünver Koluman , Erhan Ugurlu , Göksel Altınışık Ergur Y1 - 2022 PY - 2022 N1 - doi: 10.31362/patd.1017368 DO - 10.31362/patd.1017368 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 391 EP - 394 VL - 15 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.1017368 UR - https://doi.org/10.31362/patd.1017368 Y2 - 2022 ER -
EndNote %0 Pamukkale Tıp Dergisi COVID-19 case with prolonged neutropenia %A Nilüfer Yiğit , Başak Ünver Koluman , Erhan Ugurlu , Göksel Altınışık Ergur %T COVID-19 case with prolonged neutropenia %D 2022 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 15 %N 2 %R doi: 10.31362/patd.1017368 %U 10.31362/patd.1017368
ISNAD Yiğit, Nilüfer , Ünver Koluman, Başak , Ugurlu, Erhan , Altınışık Ergur, Göksel . "COVID-19 case with prolonged neutropenia". Pamukkale Tıp Dergisi 15 / 2 (Nisan 2022): 391-394 . https://doi.org/10.31362/patd.1017368
AMA Yiğit N. , Ünver Koluman B. , Ugurlu E. , Altınışık Ergur G. COVID-19 case with prolonged neutropenia. Pam Tıp Derg. 2022; 15(2): 391-394.
Vancouver Yiğit N. , Ünver Koluman B. , Ugurlu E. , Altınışık Ergur G. COVID-19 case with prolonged neutropenia. Pamukkale Tıp Dergisi. 2022; 15(2): 391-394.
IEEE N. Yiğit , B. Ünver Koluman , E. Ugurlu ve G. Altınışık Ergur , "COVID-19 case with prolonged neutropenia", Pamukkale Tıp Dergisi, c. 15, sayı. 2, ss. 391-394, Nis. 2022, doi:10.31362/patd.1017368
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