COVID-19 Pandemisinde Psikotik Süreç: Dopamin Etkisi

Öz

Ağır akut solunum yolu sendromu COVID-19'un küresel etkisi, fiziksel sağlığın ötesine geçerek dünya çapında ruh sağlığını önemli ölçüde etkilemiştir. Pandeminin ilk dalgasının ortasında, COVID-19 hastaları travma sonrası stres bozukluğu ve özellikle depresif semptomlar sergilemiştir. Pandemi sırasında deliryum, konfüzyon, ajitasyon ve bilinç değişikliği gibi belirtilerin yanı sıra depresyon, anksiyete ve uykusuzluk gibi yaygın ruh sağlığı sorunları da ortaya çıkmıştır. COVID-19'dan iyileşen bireyler, hastaneden taburcu olduktan sonra, dopamine bağlı olması muhtemel kalıcı psikiyatrik zorluklarla karşılaşabilirler. Dopaminerjik reseptörler, belirli virüslerin merkezi sinir sistemine bağlanma duyarlılığını artırarak virüsün erken enfeksiyon aşamalarında viral ensefaliti tetikleyebilir. Dopamin ayrıca insan bazal karotis cisimciğinin hipoksiye karşı solunum tepkisini de bozabilir. Ayrıca virüs, dopamin düzeylerini yükselterek bağışıklık sistemini etkileyebilir ve viral girişi kolaylaştırabilir. Bu bulgular, COVID-19 hastalarının ve psikoz teşhisi konmuş kişilerin tanı, tedavi ve bakımında dopaminin rolünün dikkate alınmasının önemini vurgulamaktadır. Ayırt edici özellikler sergileyen bireylere özgü müdahalelerde bulunulması çok önemlidir. Araştırmaya değer bir başka ilgi çekici konu da dopaminin COVID-19'a karşı koruma sağlayıp sağlamadığıdır. Bu derlemede, Covid-19 salgını ile dopamin arasındaki karmaşık ilişkinin aydınlatılması, potansiyel sonuçlarına ve daha fazla araştırmaya yönelik olası noktalara ışık tutulması amaçlanmaktadır.

Anahtar Kelimeler

• Covid-19
• psikoz
• dopamin
• pandemi

Psychotic Process in the COVID-19 Pandemic: Dopamine Effect

Öz

The global impact of severe acute respiratory syndrome COVID-19 has extended beyond physical health, significantly affecting mental well-being worldwide. Amid the pandemic's initial wave, COVID-19 patients exhibited symptoms of post-traumatic stress disorder and notably depressive symptoms. Alongside manifestations like delirium, confusion, agitation, and altered consciousness, prevalent mental health issues during the pandemic encompassed depression, anxiety, and insomnia. Individuals recovering from COVID-19 may face enduring psychiatric challenges post-hospital discharge, potentially linked to dopamine. Dopaminergic receptors might heighten the susceptibility of certain viruses to bind with the central nervous system, instigating viral encephalitis in the virus's early infection stages. Dopamine could also disrupt the human basal carotid body's respiratory response to hypoxia. Additionally, the virus could manipulate the immune system by elevating dopamine levels, facilitating viral entry. These findings emphasize the significance of considering dopamine's role in the diagnosis, treatment, and care of COVID-19 patients and those with diagnosed psychosis. Tailored interventions are crucial for individuals exhibiting distinctive features. Another intriguing aspect worthy of investigation is whether dopamine confers protection against COVID-19. This review article aims to elucidate the intricate relationship between the impactful COVID-19 pandemic and dopamine, shedding light on its potential implications and avenues for further exploration.

Anahtar Kelimeler

• COVID-19
• psychosis
• dopamine
• pandemic

Kaynakça

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