Schizo-obsessive Disorder

Abstract

Obsessive-compulsive features are common in schizophrenia. Current genetic, neurobiological, clinical and epidemiological data about obsessive-compulsive symptoms/disorder in schizophrenia suppose that schizophrenia combined with obsessive compulsive disorder is more than a mere comorbidity. Epidemiologic and neurobiological evidence suggest that the patients with comorbid obsessive compulsive disorder and schizophrenia may present a special category among patients with schizophrenia. Although a specific profile has not been emerged yet; clinical, neurobiological research about schizo-obsessive patients have been extensively pursued.

Keywords

• Schizophrenia, obsessive compulsive disorder, schizo-obsessive disorder.

Şizo-obsesif Bozukluk

Öz

Şizofrenide obsesif-kompulsif belirtiler yaygın olarak görülmektedir. Şizofrenide görülen obsesif-kompulsif belirtiler/bozukluk hakkındaki güncel genetik, nörobiyolojik, klinik ve epidemiyolojik veriler obsesif kompulsif bozukluk ile birlikte görülen şizofreninin bir komorbiditeden daha fazlası olduğunu, şizofreni hastaları arasında özgül bir grubu temsil ediyor olabileceğini ortaya koymuştur. Henüz bu hastalara özgü bir hastalık profili ortaya konulamadıysa da şizo-obsesif hastalarla ilişkili klinik, nörobiyolojik çalışmalar yaygın olarak yürütülmektedir.

Anahtar Kelimeler

• Şizofreni, obsesif kompulsif bozukluk, şizo-obsesif bozukluk.

Kaynakça

1. Berrios GE. Obsessive-compulsive disorder: its conceptual history in France during the 19th century. Compr Psychiatry 1989; 30:283–295.
2. Kayahan B, Ozturk O, Veznedaroglu B, Eraslan D. Obsessive-compulsive symptoms in schizophrenia: prevalence and clinical correlates. Psychiatry Clin Neurosci 2005; 59:291–295.
3. Lykouras L, Alevizos B, Michalopoulou P, Rabavilas A. Obsessive compulsive symptoms induced by atypical antipsychotics: a review of the reported cases. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27:333-346.
4. Hwang MY, Hollander E. Schizo-obsessive disorders. Psychiatr Ann 1993; 23:39640
5. Bottas A, Cooke RG, Richter MA. Comorbidity and pathophysiology of obsessivecompulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia? J Psychiatry Neurosci 2005; 30:187-193.
6. Martin EB. The evidence before one’s eyes: a case report on schizo-obsessive disorder. Case Reports in Psychiatry 2012; 851785.
7. Kayahan B, Ozturk O, Veznedaroglu B. Şizofrenide obsesif kompulsif belirtiler. Turk Psikiyatri Derg 2005; 16:205-215.
8. Attademo L, De Giorgio G, Quartesan R, Moretti P. Schizophrenia and obsessivecompulsive disorder:from comorbidity to schizo-obsessive disorder. Riv Psichiatr 2012; 47:106-115.

9. Özer S, Tiryaki A. Şizofreni ile ilişkili yeni bir kavram: şizo-obsesif bozukluk. In Şizofreni ve Diğer Psikotik Bozukluklar (Eds H Soygür, K Alptekin, C Atbaşoğlu, H Herken):321-329. Ankara, Türkiye Psikiyatri Derneği, 2007.
10. Foa EB, Kozak MJ. DSM-IV field trial: obsessive-compulsive disorder. Am J Psychiatry 1995; 152:90-96.
11. Insel TR, Akiskal HS. Obsessive-compulsive disorder with psychotic features: a phenomenologic analysis. Am J Psychiatry 1986; 143:1527-1533.
12. Aydın A, Ceylan ME, Türkcan A. Şizofrenide obsesif-kompulsif fenomenler: bir gözden geçirme. Klinik Psikofarmakoloji Bülteni 2008; 18:222-234
13. Erdoğan S. Şizofrenide obsesif kompulsif belirtiler. In Neden Nasıl Şizofreni (Ed S Candansayar):121-145. Ankara, Peday Yayınevi, 2005.
14. Amerikan Psikiyatri Birliği. Psikiyatride Hastalıkların Tanımlanması ve Sınıflandırılması El Kitabı,Yeniden Gözden Geçirilmiş Dördüncü Baskı, (DSM-IV-TR), Amerikan Psikiyatri Birliği Washington DC, 2000’den çeviren Köroğlu E, Hekimler Yayın Birliği, Ankara, 2001.
15. Sevinçok L.Şizofrenide obsesif-kompulsif belirtiler (Şizoobsesif bozukluk). In Psikiyatri Temel Kitabı 2. baskı(Eds. E Köroğlu, C Güleç):217-226. Ankara, HYB Basım Yayın, 2007.
16. Zohar J. Is there room for another diagnostic subtype-the schizoobsessive subtype? CNS Spectr 1997; 2:49-50.
17. Poyurovsky M, Fuchs C, Faragian S, Kriss V, Weisman G, Pashinian A. et al. Preferential aggregation of obsessivecompulsive spectrum disorder in schizophrenia patients with obsessive-compulsive disorder. Can J Psychiatry 2006; 51:746-754
18. Cunill R, Castells X. Schizo-obsessive disorder. In Handbook of Schizophrenia Spectrum Disorders (Ed. MS Ritsner):403-448. Heidelberg, Springer, 2011
19. Cunill R, Castells X, Simeon D. Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis. J Clin Psychiatry 2009; 70:70-82.
20. Tibbo P, Warneke L. Obsessive-compulsive disorder in schizophrenia: epidemiologic and biologic overlap. J Psychiatry Neurosci 1999; 24:15-24.
21. Fenton WS, McGlashan TH The prognostic significance of obsessive-compulsive symptoms in schizophrenia. Am J Psychiatry 1986; 143:437-441.
22. Berman I, Kalinowski A, Berman SM, Lengua J, Green AI. Obsessive and compulsive symptoms in chronic schizophrenia. Compr Psychiatry 1995; 36:6-10.
23. Poyurovsky M, Hramenkov S, Isakov V, Rauchverger B, Modai I, Schneidman M. Obsessive-compulsive disorder in hospitalized patients with chronic schizophrenia. Psychiatr Res 2001; 102:49-57.
24. Poyurovsky M, Fuchs C, Weizman A. Obsessive-compulsive disorder in patients with first episode schizophrenia. Am J Psychiatry 1999; 156:1998-2000.
25. Tibbo P, Kraetsch M, Chue P,Warneke L. Obsessive-compulsive disorder in schizophrenia. J Psychiatr Res 2000; 34:139-146.
26. Poyurovsky M, Bergman J, Weizman R. Obsessive-compulsive disorder in elderly schizophrenia patients. J Psychiatr Res 2006; 40:189-191.
27. Nechmad A, Ratzoni G, Poyurovsky M, Meged S, Avidan G, Fuchs C et al. Obsessive-compulsive disorder in adolescent schizophrenia patients. Am J Psychiatry 2003; 160:1002-1004.
28. Buckeley PF, Miller BJ, Lehrer DS. Psychiatric comorbidities and schizophrenia. Schizophr Bull 2009; 35:383-402.
29. Eisen J, Rasmussen S. Obsessive-compulsive disorder with psychotic features. J Clin Psychiatry 1993; 54:373-9
30. Thomsen PH, Jensen J. Obsessive-compulsive ddisorder: admission patterns and diagnostic stability. A case register study. Acta Psychiatr Sound 1994; 90:19-24
31. Poyurovsky M, Kriss V, Weisman G, Faragian S, Schneidman M, Fuchs C et al. Familial aggregation of schizophreniaspectrum disorders and obsessive-compulsive associated disorders in schizophrenia probands with and without OCD. Am J Med Genet B Neuropsychiatr Genet 2005; 133:31–36.
32. Poyurovsky M, Michaelovsky E, Frisch A, Knoll G, Amir I, Finkel B et al. COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study. Neurosci Lett 2005; 389:21–24.
33. Zinkstok J, van Nimwegen L, van Amelsvoort T, de Haan L, Yusuf MA, Baas F et al. Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: preliminary results. Psychiatry Res 2008; 157:1-8. Lykouras L, Alevizos B, Michalopoulou P, Rabavilas A. Obsessive-compulsive symptoms induced by atypical antipsychotics: a review of the reported cases.. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27:333-346.
34. De Haan L, Beuk N, Hoogenboom B, Dingemans P, Linszen D. Obsessivecompulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent onset schizophrenia or related disorders. J Clin Psychiatry 2002; 63:104–107.
35. Veznedaroglu B, Ercan ES, Kayahan B, Varan A, Bayraktar E. Reduced short-term obsessivecompulsive symptoms in schizophrenic patients treated with risperidone: a single-blind prospective study. Hum Psychopharmacol 2003; 18:635-640.
36. Stein DJ. Neurobiology of the obsessive–compulsive spectrum disorders. Biol Psychiatry 2000; 47:296-304.
37. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43:114-124.
38. Ma N, Tan LW, Wang Q, Li ZX, Li LJ. Lower levels of whole blood serotonin in obsessivecompulsive disorder and in schizophrenia with obsessive-compulsive symptoms. Psychiatry Res 2007; 150:61-69.
39. Aoyama F, Iida J, Inoue M, Iwasaka H, Sakiyama S, Hata K. Brain imaging in childhood- and adolescent-onset schizophrenia associated with obsessive-compulsive symptoms. Acta Psychiatr Scand 2000; 1002:32-37.
40. Iida J, Matumura K, Aoyama F, Iwasaka H, Hirao F, Sakiyama S et al. Cerebral MRI findings in childhood onset schizophrenia, comparison on patients with prodromal obsessive-compulsive symptoms and those without symptoms. In Recent Progress in Child and Adolescent Psychiatry Vol.2 (Ed M Hanada):75-83. Tokyo, Springer, 19 Levine JB, Gruber SA, Baird AA, Yurgelun-Todd DA. Obsessivecompulsive disorder among schizophrenic patients: an exploratory study using fMRI data. Compr Psychiatry 1998; 39:308-312.
41. Berman I, Merson A, Viegner B, Losonczy MF, Pappas D, Green AI. Obsessions and compulsions as a distinct cluster of symptoms in schizophrenia: a neuropsychological study. J Nerv Ment Dis 1998; 186:150-156.
42. Lysaker PH, Bryson GJ, Marks KA, Greig TC, Bell MD. Association of obsessions and compulsions in schizophrenia with neurocognition and negative symptoms. J Neuropsychiatry Clin Neurosci 2002; 14:449-453.
43. Lysaker PH, Whitney KA, Davis LW. Associations of executive function with concurrent and prospective reports of obsessive-compulsive symptoms in schizophrenia. J Neuropsychiatry Clin Neurosci 2009; 21:38-42
44. Borkowska A, Pilaczynska E, Rybakowski JK. The frontal lobe neuropsychological tests in patients with schizophrenia and/or obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 2003; 15:359-362.
45. Pallanti S, Castellini G, Chamberlain SR, Quercioli L, Zaccara G, Fineberg NA. Cognitive event-related potentials differentiate schizophrenia with obsessivecompulsive disorder (schizo-OCD) from OCD and schizophrenia without OC symptoms. Psychiatry Res 2009; 170:52-60.
46. Sevincok L, Akoglu A, Kokcu F. Suicidality in schizophrenic patients with and without obsessive-compulsive disorder. Schizopr Res 2007; 90:198-202.
47. Hwang MY, Morgan JE, Losconzcy MF. Clinical and neuropsychological profiles of obsessive compulsive schizophrenia: a pilot study. J Neuropsychiatr Clin Neurosci 2000; 12:91-94.
48. Poyurovsky M, Kriss V, Weisman G, Faragian S, Kurs R, Schneidman M. Comparison of clinical characteristics and comorbidity in schizophrenia patients with and without obsessive–compulsive disorder: schizophrenic and obsessivecompulsive symptoms in schizophrenia. J Clin Psychiatry 2003; 64:1300-1307.
49. Poyurovsky M, Faragian S, Shabeta A, Kosov A. Comparison of clinical characteristics, co-morbidity and pharmacotherapy in adolescent schizophrenia patients with and without obsessive-compulsive disorder. Psychiatry Res 2008; 159:133-139.
50. Faragian S, Fucks C, Pashinian A, Weizman R, Weizman A, Poyurovsky M. Age-ofonset of schizophrenic and obsessive-compulsive symptoms in patients with schizoobsessive disorder. Psychiatr Res 2012; 197:19-22
51. Özdemir Ö, Tükel R, Türksoy N, Üçok A. Clinical characteristics in obsessivecompulsive disorder with schizophrenia. Compr Psychiatry 2003; 44:311-316. Volkan Gelegen, Dr., Çukurova Üniv.Tıp Fakültesi Psikiyatri ABD, Adana; Lut Tamam, Prof. Dr., Çukurova Üniv.Tıp Fakültesi Psikiyatri ABD, Adana. Yazışma Adresi/Correspondence: Volkan Gelegen, Çukurova Üniv.Tıp Fak. Psikiyatri ABD, Adana, Turkey. E-mail: [e-mail] Yazarlar bu makale ile ilgili herhangi bir çıkar çatışması bildirmemişlerdir. The authors reported no conflict of interest related to this article. Çevrimiçi adresi / Available online at: www.cappsy.org/archives/vol5/no2/ Çevrimiçi yayım / Published online 23 Şubat/February 23, 2013; doi:10.5455/cap.20130513