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COVID-19 Epidemiyolojisi

Yıl 2020, Cilt: 3 Sayı: S1, 1 - 13, 15.05.2020

Öz

31 Aralık 2019'da Dünya Sağlık Örgütü (WHO), Çin'in Hubei Eyaleti, Wuhan Şehrinde tespit edilen nedeni bilinmeyen pnömoni vakalarından oluşan bir küme hakkında bilgilendirildi. 12 Ocak 2020'de vakalardan elde edilen örneklerde yeni bir koronavirüs tespit edildiği ve virüs genetik dizi analizi sonucunda, salgının virüs nedenli olduğunu açıklandı. Bu virüs SARS-CoV-2 ve buna bağlı hastalık COVID-19 olarak adlandırıldı. 26 Nisan 2020 itibariyle, Dünya genelinde 210 Ülke 203 binden den fazla ölümle birlikte 2.9 milyondan fazla vaka teşhis edilmiştir. Ülkemizde Sağlık Bakanlığı yoğun çalışmaları neticesinde vakaların izolasyonu ve yakın temaslıların karantinası ile birlikte epidemiyolojik araştırmalar yoluyla COVID-19'un yayılmasını kontrol altına almaya çalışmaktadır. Bununla birlikte, olası yayılma derecesini belirlemek için yetersiz epidemiyolojik veriler çalışmalar süreci zorlaştırmaktadır. Olası bulaşma noktaları epidemiyolojik araştırmalarla retrospektif olarak tanımlansa bile, epidemiyolojik araştırmaların desteklenmesinde kullanımını göstermede önemli bir rol oynamıştır. Korunma ve hafifletme önlemleri yoğunlaşırken, hastalığın tedavisi konusunda farmakolojik bileşikler geliştirilirken, COVID-19 yayılmaya devam etmektedir. Bu makalede COVID-19 ile ilgili güncel verilerin tanımlayıcı araştırmalar çerçevesinde kişi yer, zaman özellikleri açısından kısa bir incelemesi sunulmaktadır.

Kaynakça

  • 1. Bilgel N.: Bölüm 1: Epidemiyoloji Nedir? Bölüm 3: Çalışma Tipleri. (Basic Epidemiology .Eds:R. Beaglehole, R. Bonita, T. Kjellström. WHO -1993). Temel Epidemiyoloji Bursa. Nobel & Güneş Tıp Kitapevi.1997.p.1-5,37-45
  • 2. Tezcan S: Bölüm 2: Epidemiyolojinin Tarihsel Gelişim- 11-Bulaşıcı Hastalıklar Epidemiyolojisi. Temel Epidemiyoloji. Ankara. Hipokrat Kitabevi. 2017.p:23-25,179-198.
  • 3. Bulut C , Kato Y. Epidemiology of COVID-19 Turk J Med Sci 2020;50:563-70.
  • 4. Ramirez VB : What is R0? Gauging Contagious infections. https://www.healthline.com/health /r-nought-reproduction-number: Erişim 20.04.2020
  • 5. Sanche S , Lin YT, Xu C, Romero-Severson E, Hengartner NW et al. The novel coronavirus, 2019nCoV, is highly contagious and more infectious than initially estimated. MedRxiv 2020. https:// doi. org/10.1101/2020.02.07.20021154.
  • 6. Lipsitch M, Cohen T, Cooper B, Robins JM, Ma S et al. Transmission dynamics and control of severe acute respiratory syndrome. Science 2003; 300(5627):1966-70. doi: 10.1126/ science.1086616
  • 7. World Health Organization (2020). WHO Director-General’s opening remarks at the media briefing on COVID-19 (online). Website https:// www.who.int/dg/speeches/detail/who-directorgeneral-s-opening-remarks-at-the-mediabriefing-on-covid-19.
  • 8. World Health Organization (2020). WHO characterizes COVID-19 as a pandemic (online) Website https:// www.who. int/emergencies/diseases/novelcoronavirus-2019/events-as-they-happen.
  • 9. Petersen E, Gökengin D. SARS-CoV-2 epidemiology and control, different scenarios for Turkey. Turk J Med Sci 2020;50:509-14
  • 10. World Health Organization Director-General’s opening remarks at the media briefing on COVID-19 - 24 February 2020 https://www.who. int/dg/speeches/detail/who-director-general-sopening-remarks-at-the-media-briefing-oncovid-19. Erişim 26.2.2020.
  • 11. CDC COVID-19 Response Team. Geographic Differences in COVID-19 Cases, Deaths, and Incidence .United States, February 12–April 7, 2020. MMWR Morb Mortal Wkly Rep 2020.
  • 12. World Health Organization. Novel coronavirus situation report -2. January 22, 2020. https://www. who.int/docs/default-source/coronaviruse/ situation-reports/20200122-sitrep-2-2019-ncov. pdf. Erişim 23.01.2020.
  • 13. Van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med 2020;382:1564.
  • 14. Chen W, Lan Y, Yuan X, et al. Detectable 2019nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect 2020;9:469.
  • 15. Wang W, Xu Y, Gao R, et al. Detection of SARSCoV-2 in Different Types of Clinical Specimens. JAMA 2020. JAMA. 2020 Mar 11. doi: 10.1001/ jama.2020.3786. [Epub ahead of print]
  • 16. Colavita F, Lapa D, Carletti F, et al. SARS-CoV-2 Isolation From Ocular Secretions of a Patient With COVID-19 in Italy With Prolonged Viral RNA Detection. Ann Intern Med 2020.
  • 17. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. Gastroenterology 2020.
  • 18. Zheng S, Fan J, Yu F, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ 2020;369:m1443.
  • 19. Report of the WHO-China Joint Mission on Coronavirus DIsease 2019 (COVID-2019). February 16-24, 2020. http://www.who.int/docs/defaultsource/coronaviruse/who-china-joint-mission-oncovid-19-final-report.pdf. Erişim 04.03 2020.
  • 20. Kenneth McIntosh,K : Coronavirus disease 2019 (COVID-19): Epidemiology, virology, clinical features, diagnosis, and prevention https://www. uptodate.com/contents/coronavirus-disease. Erişim 20.04.2020
  • 21. Wong SC, Kwong RT, Wu TC, et al. Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect 2020; pii: S01956701(20)30174-2. doi: 10.1016/j.jhin.2020.03.036.
  • 22. Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med 2020;382:1177.
  • 23. To KK, Tsang OT, Leung WS, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis 2020.
  • 24. Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature 2020. 25. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020.
  • 26. Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med 2020;382:970.
  • 27. Kupferschmidt K. Study claiming new coronavirus can be transmitted by people without symptoms was flawed. Science. February 3, 2020. https://www. sciencemag.org/news/2020/02/paper-nonsymptomatic-patient-transmitting-coronaviruswrong (Erişim 04.02.2020).
  • 28. Yu P, Zhu J, Zhang Z, et al. A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-toperson transmission during the incubation period. J Infect Dis 2020.
  • 29. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA 2020. JAMA. 2020 Feb 21. doi: 10.1001/jama.2020.2565. [Epub ahead of print]
  • 30. Hu Z, Song C, Xu C, et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Sci China Life Sci 2020.
  • 31. Qian G, Yang N, Ma AHY, et al. A COVID-19 Transmission within a family cluster by presymptomatic infectors in China. Clin Infect Dis. 2020 Mar 23. pii: ciaa316. doi: 10.1093/cid/ ciaa316. [Epub ahead of print]
  • 32. Wei WE, Li Z, Chiew CJ, et al. Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020. MMWR Morb Mortal Wkly Rep 2020.
  • 33. Li Z, Yi Y, Luo X, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020 Feb 27. doi: 10.1002/jmv.25727. [Epub ahead of print]
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  • 35. Liu Y, Yan LM, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020;Mar 19 doi: 10.1016/S14733099(20)30232-2 [Epub ahead of print].
  • 36. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):10541062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
  • 37. Xu K, Chen Y, Yuan J, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. 2020 Apr 9. pii: ciaa351. doi: 10.1093/cid/ciaa351. [Epub ahead of print].
  • 38. Xiao AT, Tong YX, Zhang S. Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients. Clin Infect Dis. 2020 Apr 19. pii: ciaa460. doi: 10.1093/cid/ciaa460. [Epub ahead of print]
  • 39. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Feb 7. doi: 10.1001/ jama.2020.1585. [Epub ahead of print]
  • 40. McMichael TM, Clark S, Pogosjans S, et al. COVID-19 in a Long-Term Care Facility - King County, Washington, February 27-March 9, 2020. MMWR Morb Mortal Wkly Rep 2020;69:339.
  • 41. Kakimoto K, Kamiya H, Yamagishi T, et al. Initial Investigation of Transmission of COVID-19 Among Crew Members During Quarantine of a Cruise Ship - Yokohama, Japan, February 2020. MMWR Morb Mortal Wkly Rep 2020;69:312.
  • 42. Burke RM, Midgley CM, Dratch A, et al. Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 - United States, JanuaryFebruary 2020. MMWR Morb Mortal Wkly Rep 2020;69:245.
  • 43. COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention. Coronavirus Disease-19: Summary of 2,370 Contact Investigations of the First 30 Cases in the Republic of Korea. Osong Public Health Res Perspect. 2020 Apr;11(2):81-84. doi: 10.24171/j. phrp.2020.11.2.04.
  • 44. Ghinai I, Woods S, Ritger KA, et al. Community Transmission of SARS-CoV-2 at Two Family Gatherings . Chicago, Illinois, February–March 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):446-450. doi: 10.15585/mmwr. mm6915e1.
  • 45. Pung R, Chiew CJ, Young BE, et al. Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Lancet 2020;395:1039.
  • 46. Ong SWX, Tan YK, Chia PY, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient. JAMA. 2020 Mar 4. doi: 10.1001/jama.2020.3227. [Epub ahead of print]
  • 47. Liu Y, Yan LM, Wan L, Xiang TX, Le A et al. Viral dynamics in mild and severe cases of COVID-19. The Lancet Infectious Diseases 2020; pii: S14733099(20)30232-2. doi: 10.1016/S1473- 3099(20)30232-2
  • 48. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID- outbreak in China: summary of a report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13): 1239-42. doi: 10.1001/jama.2020.2648
  • 49. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARSCoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; April 6, (Epub ahead of print). doi:10.1001/jama.2020.5394
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  • 51. Kang YJ. Mortality rate of infection with COVID-19 in Korea from the perspective of underlying disease Disaster Medicine and Public Health Preparedness Disaster Med Public Health Prep. 2020;3:31:1-3. doi: 10.1017/dmp.2020.60. [Epub ahead of print]
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Epidemiology of COVID-19

Yıl 2020, Cilt: 3 Sayı: S1, 1 - 13, 15.05.2020

Öz

On December 31, 2019, the World Health Organization (WHO) was informed about a cluster of unknown causes of pneumonia detected in Wuhan City, Hubei Province, China. On January 12, 2020, a new coronavirus was detected in samples from cases, and the first analysis of virus genetic sequences suggested that this was the cause of the epidemic. This virus was called SARS-CoV-2 and associated disease COVID-19. As of April 26, 2020, more than 2.9 million cases were identified, with more than 203 000 deaths from 210 countries worldwide. As a result of the intensive studies of the Ministry of Health in our country, it is trying to control the spread of COVID-19 through the isolation of cases and quarantine of close contacts, through epidemiological research. However, insufficient epidemiological data to determine the degree of possible spread make studies more difficult (complicate the studies) . Although possible points of contamination have been identified retrospectively by epidemiological research, they have played an important role in demonstrating their use in supporting epidemiological research. COVID-19 continues to spread, while pharmacological compounds are being developed in the treatment of the disease, and while prevention and mitigation measures are intensifying. In this article (research), a brief review of current data about COVID-19 in terms of person-place and time characteristics is presented within the framework of descriptive studies

Kaynakça

  • 1. Bilgel N.: Bölüm 1: Epidemiyoloji Nedir? Bölüm 3: Çalışma Tipleri. (Basic Epidemiology .Eds:R. Beaglehole, R. Bonita, T. Kjellström. WHO -1993). Temel Epidemiyoloji Bursa. Nobel & Güneş Tıp Kitapevi.1997.p.1-5,37-45
  • 2. Tezcan S: Bölüm 2: Epidemiyolojinin Tarihsel Gelişim- 11-Bulaşıcı Hastalıklar Epidemiyolojisi. Temel Epidemiyoloji. Ankara. Hipokrat Kitabevi. 2017.p:23-25,179-198.
  • 3. Bulut C , Kato Y. Epidemiology of COVID-19 Turk J Med Sci 2020;50:563-70.
  • 4. Ramirez VB : What is R0? Gauging Contagious infections. https://www.healthline.com/health /r-nought-reproduction-number: Erişim 20.04.2020
  • 5. Sanche S , Lin YT, Xu C, Romero-Severson E, Hengartner NW et al. The novel coronavirus, 2019nCoV, is highly contagious and more infectious than initially estimated. MedRxiv 2020. https:// doi. org/10.1101/2020.02.07.20021154.
  • 6. Lipsitch M, Cohen T, Cooper B, Robins JM, Ma S et al. Transmission dynamics and control of severe acute respiratory syndrome. Science 2003; 300(5627):1966-70. doi: 10.1126/ science.1086616
  • 7. World Health Organization (2020). WHO Director-General’s opening remarks at the media briefing on COVID-19 (online). Website https:// www.who.int/dg/speeches/detail/who-directorgeneral-s-opening-remarks-at-the-mediabriefing-on-covid-19.
  • 8. World Health Organization (2020). WHO characterizes COVID-19 as a pandemic (online) Website https:// www.who. int/emergencies/diseases/novelcoronavirus-2019/events-as-they-happen.
  • 9. Petersen E, Gökengin D. SARS-CoV-2 epidemiology and control, different scenarios for Turkey. Turk J Med Sci 2020;50:509-14
  • 10. World Health Organization Director-General’s opening remarks at the media briefing on COVID-19 - 24 February 2020 https://www.who. int/dg/speeches/detail/who-director-general-sopening-remarks-at-the-media-briefing-oncovid-19. Erişim 26.2.2020.
  • 11. CDC COVID-19 Response Team. Geographic Differences in COVID-19 Cases, Deaths, and Incidence .United States, February 12–April 7, 2020. MMWR Morb Mortal Wkly Rep 2020.
  • 12. World Health Organization. Novel coronavirus situation report -2. January 22, 2020. https://www. who.int/docs/default-source/coronaviruse/ situation-reports/20200122-sitrep-2-2019-ncov. pdf. Erişim 23.01.2020.
  • 13. Van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med 2020;382:1564.
  • 14. Chen W, Lan Y, Yuan X, et al. Detectable 2019nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect 2020;9:469.
  • 15. Wang W, Xu Y, Gao R, et al. Detection of SARSCoV-2 in Different Types of Clinical Specimens. JAMA 2020. JAMA. 2020 Mar 11. doi: 10.1001/ jama.2020.3786. [Epub ahead of print]
  • 16. Colavita F, Lapa D, Carletti F, et al. SARS-CoV-2 Isolation From Ocular Secretions of a Patient With COVID-19 in Italy With Prolonged Viral RNA Detection. Ann Intern Med 2020.
  • 17. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. Gastroenterology 2020.
  • 18. Zheng S, Fan J, Yu F, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ 2020;369:m1443.
  • 19. Report of the WHO-China Joint Mission on Coronavirus DIsease 2019 (COVID-2019). February 16-24, 2020. http://www.who.int/docs/defaultsource/coronaviruse/who-china-joint-mission-oncovid-19-final-report.pdf. Erişim 04.03 2020.
  • 20. Kenneth McIntosh,K : Coronavirus disease 2019 (COVID-19): Epidemiology, virology, clinical features, diagnosis, and prevention https://www. uptodate.com/contents/coronavirus-disease. Erişim 20.04.2020
  • 21. Wong SC, Kwong RT, Wu TC, et al. Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect 2020; pii: S01956701(20)30174-2. doi: 10.1016/j.jhin.2020.03.036.
  • 22. Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med 2020;382:1177.
  • 23. To KK, Tsang OT, Leung WS, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis 2020.
  • 24. Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature 2020. 25. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020.
  • 26. Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med 2020;382:970.
  • 27. Kupferschmidt K. Study claiming new coronavirus can be transmitted by people without symptoms was flawed. Science. February 3, 2020. https://www. sciencemag.org/news/2020/02/paper-nonsymptomatic-patient-transmitting-coronaviruswrong (Erişim 04.02.2020).
  • 28. Yu P, Zhu J, Zhang Z, et al. A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-toperson transmission during the incubation period. J Infect Dis 2020.
  • 29. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA 2020. JAMA. 2020 Feb 21. doi: 10.1001/jama.2020.2565. [Epub ahead of print]
  • 30. Hu Z, Song C, Xu C, et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Sci China Life Sci 2020.
  • 31. Qian G, Yang N, Ma AHY, et al. A COVID-19 Transmission within a family cluster by presymptomatic infectors in China. Clin Infect Dis. 2020 Mar 23. pii: ciaa316. doi: 10.1093/cid/ ciaa316. [Epub ahead of print]
  • 32. Wei WE, Li Z, Chiew CJ, et al. Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020. MMWR Morb Mortal Wkly Rep 2020.
  • 33. Li Z, Yi Y, Luo X, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020 Feb 27. doi: 10.1002/jmv.25727. [Epub ahead of print]
  • 34. US Food and Drug Administration. Emergency Use Authorizations. https://www.fda.gov/ emergency-preparedness-and-response/ coronavirus-disease-2019-covid-19/coronavirusdisease-2019-covid-19-frequently-askedquestions. Erişim 16.04.2020
  • 35. Liu Y, Yan LM, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020;Mar 19 doi: 10.1016/S14733099(20)30232-2 [Epub ahead of print].
  • 36. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):10541062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
  • 37. Xu K, Chen Y, Yuan J, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. 2020 Apr 9. pii: ciaa351. doi: 10.1093/cid/ciaa351. [Epub ahead of print].
  • 38. Xiao AT, Tong YX, Zhang S. Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients. Clin Infect Dis. 2020 Apr 19. pii: ciaa460. doi: 10.1093/cid/ciaa460. [Epub ahead of print]
  • 39. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Feb 7. doi: 10.1001/ jama.2020.1585. [Epub ahead of print]
  • 40. McMichael TM, Clark S, Pogosjans S, et al. COVID-19 in a Long-Term Care Facility - King County, Washington, February 27-March 9, 2020. MMWR Morb Mortal Wkly Rep 2020;69:339.
  • 41. Kakimoto K, Kamiya H, Yamagishi T, et al. Initial Investigation of Transmission of COVID-19 Among Crew Members During Quarantine of a Cruise Ship - Yokohama, Japan, February 2020. MMWR Morb Mortal Wkly Rep 2020;69:312.
  • 42. Burke RM, Midgley CM, Dratch A, et al. Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 - United States, JanuaryFebruary 2020. MMWR Morb Mortal Wkly Rep 2020;69:245.
  • 43. COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention. Coronavirus Disease-19: Summary of 2,370 Contact Investigations of the First 30 Cases in the Republic of Korea. Osong Public Health Res Perspect. 2020 Apr;11(2):81-84. doi: 10.24171/j. phrp.2020.11.2.04.
  • 44. Ghinai I, Woods S, Ritger KA, et al. Community Transmission of SARS-CoV-2 at Two Family Gatherings . Chicago, Illinois, February–March 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):446-450. doi: 10.15585/mmwr. mm6915e1.
  • 45. Pung R, Chiew CJ, Young BE, et al. Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Lancet 2020;395:1039.
  • 46. Ong SWX, Tan YK, Chia PY, et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient. JAMA. 2020 Mar 4. doi: 10.1001/jama.2020.3227. [Epub ahead of print]
  • 47. Liu Y, Yan LM, Wan L, Xiang TX, Le A et al. Viral dynamics in mild and severe cases of COVID-19. The Lancet Infectious Diseases 2020; pii: S14733099(20)30232-2. doi: 10.1016/S1473- 3099(20)30232-2
  • 48. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID- outbreak in China: summary of a report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13): 1239-42. doi: 10.1001/jama.2020.2648
  • 49. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARSCoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; April 6, (Epub ahead of print). doi:10.1001/jama.2020.5394
  • 50. Istituto Superiore di Sanità (2020). Integrated surveillance of COVID-19 in Italy (online). Website https://www.epicentro. iss.it/en/ coronavirus/ bollettino/Infografica_6aprile%20 ENG. pdf . Erişim 07.04.2020).
  • 51. Kang YJ. Mortality rate of infection with COVID-19 in Korea from the perspective of underlying disease Disaster Medicine and Public Health Preparedness Disaster Med Public Health Prep. 2020;3:31:1-3. doi: 10.1017/dmp.2020.60. [Epub ahead of print]
  • 52. World Health Organization (2020). Coronavirus disease 2019 (COVID-19) Situation Report–84 (online). Website https:// https://www.who.int/ emergencies/diseases/novel-coronavirus-2019. Erişim 26.04.2020).
  • 53. Istituto Superiore di Sanità (2020). Characteristics of COVID-19 patients dying in Italy Report based on available data on April 2nd, 2020 (online). Website https://www.epicentro.iss.it/en/ coronavirus/bollettino/Report-COVID-2019_2_ april_2020. pdf. Erişim 07.04.2020.
  • 54. Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health-care resource availability. The Lancet Global Health 2020;8 (4): e480. doi: 10.1016/ S2214-109X(20)30068-1
  • 55. Korea Center for Disease Control and Prevention (2020). The updates of the COVID-19 in the Republic of Korea (online). Website. https://www. cdc.go.kr/board/board. es?. Erişim 28.03.2020.
  • 56. Lee VJ, Chiew CJ, Khong WX. Interrupting transmission of COVID-19: lessons from containment efforts in Singapore. Journal of Travel Medicine 2020; pii: taaa039. doi: 10.1093/ jtm/ taaa039 (Epub ahead of print).
  • 57. Demirbilek Y, Pehlivantürk G, Özgüler ZÖ, Meşe EA :COVID-19 outbreak control, example of ministry of health of Turkey . Turk J Med Sci .2020;50:489-494 58. Türkiye Cumhuriyeti Sağlık Bakanlığı, https:// covid19bilgi.saglik.gov.tr/tr/alinan-karalar.html. Erişim 25 .04 2020.
Toplam 56 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Diş Hekimliği, Eczacılık ve İlaç Bilimleri, Toksikoloji , Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

Halim İşsever Bu kişi benim 0000-0002-5435-706X

Tuğçe İşsever Bu kişi benim 0000-0002-9059-8709

Gözde Öztan Bu kişi benim 0000-0002-2970-1834

Yayımlanma Tarihi 15 Mayıs 2020
Gönderilme Tarihi 20 Nisan 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 3 Sayı: S1

Kaynak Göster

MLA İşsever, Halim vd. “COVID-19 Epidemiyolojisi”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, c. 3, sy. S1, 2020, ss. 1-13.