Effects of Probiotics on Acne Vulgaris

Öz

Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes increased colonization of Cutibacterium acnes in hair follicles, follicular hyperkeratinization, excessive sebum production, and immunological and inflammatory processes. It has been reported that several strains of C. acnes may play role in acne. However, acne is commonly associated with microbial dysbiosis. Studies show that probiotics can have effects on treating acne by providing microbial diversity, controlling the growth of C. acnes strains, and reducing the production of sebum and inflammatory cytokines. Probiotics have also been reported to have potential effects on systemic inflammation, oxidative-stress, tissue lipid content, and even mood. However, since the majority of studies in this area are in vitro, further studies are needed to prove the true efficacy and safety of probiotics. In this study, current literature information is thought to address the effects of probiotics on the development of acne vulgaris.

Anahtar Kelimeler

• Acne vulgaris
• probiotics
• microbiota

Probiyotiklerin Akne Vulgaris’e Etkisi

Öz

Akne vulgaris, pilosebase ünitenin yaygın bir kronik inflamatuar hastalığıdır. Patofizyolojisi, kıl köklerinde Cutibacterium acnes kolonizasyonunun artmasını, foliküler hiperkeratinizasyonu, aşırı sebum üretimini ve immünolojik ve inflamatuar süreçleri içermektedir. C. acnes’in birkaç suşunun aknede rol oynayabileceği bildirilmiştir. Bununla birlikte akne yaygın olarak mikrobiyal disbiyozisle ilişkilidir. Çalışmalar; probiyotiklerin, mikrobiyal çeşitliliği sağlayarak, C. acnes suşlarının büyümesini kontrol ederek ve sebum ve inflamatuar sitokinlerin üretimini azaltarak akne tedavisinde etkileri olabileceğini göstermektedir. Probiyotiklerin ayrıca, sistemik inflamasyonu, oksidatif stresi, doku lipit içeriğini ve hatta ruh halini etkileme potansiyelinin de, aknede etkileri olabileceği bildirilmiştir. Ancak bu alanda yapılan çalışmaların çoğunluğu in vitro olduğundan, probiyotiklerin gerçek etkinlik ve güvenliğini kanıtlamak için daha ileri çalışmalara ihtiyaç duyulmaktadır. Bu çalışmada, güncel literatür bilgileriyle probiyotiklerin akne vulgaris gelişimi üzerine etkilerine değinilmesi düşünülmektedir.

Anahtar Kelimeler

• Akne vulgaris
• probiyotikler
• Mikrobiota

Kaynakça

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