TERSİYER BİR MERKEZİN GEBE POPULASYONDA COVİD-19 DENEYİMİ VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Yıl 2022, Cilt: 7 Sayı: Covid-19 Ek Sayısı, 116 - 124, 23.06.2022

Burcu Timur Bergen Laleli Koç Hakan Timur

https://doi.org/10.25279/sak.1100662

Öz

Amaç: Bu çalışmadaki amaç, Covid-19 enfeksiyonunun klinik özelliklerini, enfeksiyona bağlı maternal fetal yan etkilerini incelemek, bu bağlamda kliniğimizin deneyimlerini paylaşmaktır.
Gereç ve Yöntem: Ordu Üniversitesi Eğitim ve Araştırma Hastanesi’ne eylül-mayıs 2021 tarihleri arasında Covid-19 tanısı almış toplam 63 gebe tanımlandı. Hastalığa bağlı semptomları, laboratuvar parametreleri, maternal ve fetal yan etkileri incelendi.
Bulgular: COVİD-19 pozitif olan 63 gebe hastadan antiviral tedavi alan ve almayan gruplar arasında yaş, BMI, gebelik haftası açısından istatistiksel olarak anlamlı bir fark saptanmadı. Hastaların en sık hastaneye başvuru şikayeti ateş (%41) idi. 63 gebelikten 1’inde ( % 1,5) covid pozitifliği sonrası fetal kayıp görüldü.
Sonuç: Covid-19 hastalığı aralık 2019 tarihinden bu yana dünyayı etkisi altına alan bir pandemiye neden olmuştur. Yüksek ateş, öksürük ve nefes darlığı en yaygın semptomlardır. Gebelikte maternal ve fetal etkileri ile ilgili veriler kısıtlıdır. Gebelikte solunum yolu hastalıklarına karşı hassasiyetin artmış olması, bu hasta grubunu hastalık etkenlerinin yıkıcı etkisine daha açık hale getirmektedir. Bu açıdan gebelik döneminde geçirilen covid-19 enfeksiyonu daha yakın takip, hastalığın daha hızlı kontrol altına alınması gerekliliklerini doğurmaktadır. Tersiyer bir merkez olan kliniğimizde takip ettiğimiz covid-19 tanılı gebelerin semptomları, laboratuvar değerleri ve obstetrik prognozları açısından literatürle uyumlu bulgular elde ettik.

Anahtar Kelimeler

COVİD-19, Gebelik, Enfeksiyon

COVID-19 EXPERIENCE IN A PREGNANT POPULATION OF A TERTIARY CENTER AND A LITERATURE REVIEW

Öz

Aim: This study aimed to examine the clinical features of COVID-19 infection, maternal and fetal side effects related to infection and share experiences of our clinic in this context.
Material and MethodsA total of 63 pregnant women diagnosed with COVID-19 were identified in a tertiary hospital between September-May 2021. Disease-related symptoms, laboratory parameters, maternal and fetal side effects were examined.
Results: No statistically significant difference in age, BMI, and gestational week was detected between the groups receiving and not receiving antiviral therapy among 63 pregnant patients who were positive for COVID-19. Fever (41.2%) was the most common patients' complaint at admission.
Conclusion: The COVID-19 disease has caused a pandemic that has affected the world since December 2019. There are limited data on maternal and fetal effects in pregnancy. The increased susceptibility to respiratory tract diseases during pregnancy makes this patient group more vulnerable to the devastating effects of disease agents. In this respect, COVID-19 infection during pregnancy necessitates the closer follow-up and faster control of the disease. We obtained findings consistent with the literature in terms of symptoms, laboratory values, and obstetric prognoses of pregnant women with COVID-19 infection that we followed up in our clinic, a tertiary center.

Anahtar Kelimeler

COVID-19, Pregnancy, Infection

Kaynakça

• Abbassi-Ghanavati, M., Greer, L. G., & Cunningham, F. G. (2009). Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol, 114(6), 1326-1331.
• Allotey, J., Stallings, E., Bonet, M., Yap, M., Chatterjee, S., Kew, T., Debenham, L., Llavall, A. C., Dixit, A., Zhou, D., Balaji, R., Lee, S. I., Qiu, X., Yuan, M., Coomar, D., Sheikh, J., Lawson, H., Ansari, K., van Wely, M., van Leeuwen, E., Kostova, E., Kunst, H., Khalil, A., Tiberi, S., Brizuela, V., Broutet, N., Kara, E., Kim, C. R., Thorson, A. et al. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. Bmj, 370, m3320.
• Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Li, J., Zhao, D., Xu, D., Gong, Q., Liao, J., Yang, H., Hou, W., & Zhang, Y. (2020). Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 395(10226), 809-815.
• Ferrer-Oliveras, R., Mendoza, M., Capote, S., Pratcorona, L., Esteve-Valverde, E., Cabero-Roura, L., & Alijotas-Reig, J. (2021). Immunological and physiopathological approach of COVID-19 in pregnancy. Arch Gynecol Obstet, 304(1), 39-57.
• Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Gao, H., Guo, L., Xie, J., Wang, G., Jiang, R., Gao, Z., Jin, Q., Wang, J., & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223), 497-506.
• Jering, K. S., Claggett, B. L., Cunningham, J. W., Rosenthal, N., Vardeny, O., Greene, M. F., & Solomon, S. D. (2021). Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. JAMA Intern Med, 181(5), 714-717.
• Joma, M., Fovet, C. M., Seddiki, N., Gressens, P., & Laforge, M. (2021). COVID-19 and Pregnancy: Vertical Transmission and Inflammation Impact on Newborns. Vaccines (Basel), 9(4).
• Martínez-Sánchez, N., De la Calle Fernández-Miranda, M., & Bartha, J. L. (2021). Safety profile of treatments administered in COVID 19 infection in pregnant women. Clin Invest Ginecol Obstet, 48(3), 100663.
• Mor, G., Aldo, P., & Alvero, A. B. (2017). The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol, 17(8), 469-482.
• Şahin, D., Tanaçan, A., Webster, S. N., & Moraloğlu Tekin, Ö. (2021). Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turk J Med Sci, 51(Si-1), 3312-3326.
• Vivanti, A. J., Vauloup-Fellous, C., Prevot, S., Zupan, V., Suffee, C., Do Cao, J., Benachi, A., & De Luca, D. (2020). Transplacental transmission of SARS-CoV-2 infection. Nat Commun, 11(1), 3572.
• Wu, Z., & McGoogan, J. M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Jama, 323(13), 1239-1242.
• Yilmaz, N., Buyuk, G. N., Ersak, D. T., Ersak, B., Kahyaoglu, I., Tas, D. Ö., & Tekin, O. M. (2021). The Impact of COVID 19 Pandemic on Pregnancy Outcomes of ART Cycles. Journal of Infertility and Reproductive Biology, 9(4), 155-159.
• Zambrano, L. D., Ellington, S., Strid, P., Galang, R. R., Oduyebo, T., Tong, V. T., Woodworth, K. R., Nahabedian, J. F., 3rd, Azziz-Baumgartner, E., Gilboa, S. M., & Meaney-Delman, D. (2020). Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep, 69(44), 1641-1647.
• Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Xia, S., & Zhou, W. (2020). Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr, 9(1), 51-60.