Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines

Duygu Yasar Sırın; Hande Akalan

doi:10.19113/sdufbed.99971

Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines

Öz

Prognostic molecular markers identified in leukemia are becoming increasingly important especially in risk stratification and to determine therapy. In this study, we investigate the role of ELK-1 transcription factor and its potential target genes in four cell lines; Daudi, Jurkat, K-562 and HL-60. To evaluate ELK-1, MCPIP, MCL-1, BCL-10, CEBPB and SRF genes expression profiles we have performed a Real-time PCR analysis on Daudi, Jurkat, K-562 and HL-60 cell lines. ELK-1 over expression concomitant with SRF overexpression was detected only in Daudi cell line while only SRF overexpression was detected in jurkat cells. Expression of MCPIP, MCL-1, BCL-10 and CEBPB genes were decreased in all cell lines. Protein levels or phosphorylation status of ELK-1, BCL-10, CEBPB, MCL-1, MCPIP and SRF, moreover, changes that may occur when ELK-1 continuous overexpression is provided or completely silenced in these cell lines have not been evaluated. These questions are suggestions for future investigations.

Anahtar Kelimeler

ELK-1,ELK-1 Target Genes; Expression profile

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Duygu Yasar Sırın

Hande Akalan Bu kişi benim

Yayımlanma Tarihi

15 Ağustos 2018

Gönderilme Tarihi

9 Ocak 2018

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2018 Cilt: 22 Sayı: 2

DOI

https://doi.org/10.19113/sdufbed.99971

IZ

https://izlik.org/JA27BR23NY

Kaynak Göster

RIS / Bibtex

APA

Yasar Sırın, D., & Akalan, H. (2018). Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 22(2), 388-392. https://doi.org/10.19113/sdufbed.99971

AMA

1.Yasar Sırın D, Akalan H. Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2018;22(2):388-392. doi:10.19113/sdufbed.99971

Chicago

Yasar Sırın, Duygu, ve Hande Akalan. 2018. “Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 22 (2): 388-92. https://doi.org/10.19113/sdufbed.99971.

EndNote

Yasar Sırın D, Akalan H (01 Ağustos 2018) Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 22 2 388–392.

IEEE

[1]D. Yasar Sırın ve H. Akalan, “Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines”, Süleyman Demirel Üniv. Fen Bilim. Enst. Derg., c. 22, sy 2, ss. 388–392, Ağu. 2018, doi: 10.19113/sdufbed.99971.

ISNAD

Yasar Sırın, Duygu - Akalan, Hande. “Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 22/2 (01 Ağustos 2018): 388-392. https://doi.org/10.19113/sdufbed.99971.

JAMA

1.Yasar Sırın D, Akalan H. Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2018;22:388–392.

MLA

Yasar Sırın, Duygu, ve Hande Akalan. “Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 22, sy 2, Ağustos 2018, ss. 388-92, doi:10.19113/sdufbed.99971.

Vancouver

1.Duygu Yasar Sırın, Hande Akalan. Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 01 Ağustos 2018;22(2):388-92. doi:10.19113/sdufbed.99971