Ailesel Akdeniz Ateşi olan hastalarda dinamik tiyol / disülfid homeostazının değerlendirilmesi

Yıl 2018, , 21 - 25, 06.12.2018

Atalay Doğru , Ayşe Balkarlı , Gözde Yıldırım Çetin , Salim Neşelioğlu Özcan Erel , Mehmet Şahin

https://doi.org/10.22312/sdusbed.462067

Öz

Amaç:
Ailesel Akdeniz Ateşi (AAA), ateş ile birlikte tekrarlayan serozal inflamasyon
ataklarını içeren, kalıtsal bir otoinflamatuar hastalıktır. Oksidatif stresin
belirteci Tiyol / disülfid homeostazı, birçok inflamatuar hastalıkta
inflamatuar sitokinlerde artış ile ilişkilidir. Çalışmamızın amacı atak dışı
dönemde AAA olan hastalarda dinamik tiyol / disülfid homeostazisini
değerlendirmektir.

Materyal-Method: Çalışmamıza atak dışı dönemde 60 AAA' li,
60 inaktif dönemde Ankilozan Spondilit (AS)’ li hasta ve 60 yaş ve cinsiyet olarak
benzer kontrol grubu dahil edildi. Erel ve Neselioğlu yöntemi kullanılarak nativ
tiyol, total tiyol ve disülfid düzeyleri ölçüldü.

Bulgular:
AAA grubunda total tiyol ve disülfid düzeyleri sağlıklı kontrollere göre
anlamlı derecede düşük bulundu. AAA grubunda nativ tiyol düzeylerinin AS
grubuna göre anlamlı olarak yüksek olduğu saptandı. Bununla birlikte, AAA ve AS
grubu arasında total tiyol düzeylerinde anlamlı bir farklılık izlenmedi. Plazma
nativ tiyol, total tiyol ve disülfid seviyeleri kullanılarak elde edilen
oranlar, AAA, AS ve kontrol grupları arasında önemli ölçüde farklıydı.

Sonuç:
AAA hastalarında AS ve control grubuna
göre düşük tiyol düzeyi saptanması, farklı patofizyolojiye sahip hastalıklarda
tiyol / disülfid dengesinin farklı şekilde etkilendiğini düşündürmektedir.
Hastalık klinik olarak inaktif bir dönemde olmasına rağmen, farklı romatizmal
hastalıklarda inflamasyon farklı düzeylerde devam edebilir.

Anahtar Kelimeler

Ankilozan Spondilit, Ailesel Akdeniz Ateşi, Tiyol / Disülfid

Evaluation of dynamic thiol/disulfide homeostasis in patients with Familial Mediterranean Fever

Öz

Introduction: Familial Mediterranean
fever (FMF) is a hereditary autoinflammatory
disease that includes recurrent episodes
of serosal inflammation, with accompanying fever. Thiol/disulfide
homeostasis, marker of oxidative stress, is associated with an increase in inflammatory cytokines in many inflammatory diseases. The aim was to
evaluate the dynamic
thiol/disulfide homeostasis in patients with FMF during
attack free period.

Material and method: In our study, 60 patients with FMF during
attack free period, 60 patients with Ankylosing
Spondylitis (AS)
during inactive period and 60 age-and sex matched controls were included. Native
thiol, total thiol and disulfide levels were measured by using the Erel and
Neselioglu method.

Result: Total thiol and disulfide levels were found to be significantly
lower in FMF group compared to healthy controls. Native thiol levels were
detected to be significantly higher in FMF group compared to AS group. However,
no significant difference was observed in total thiol levels between FMF and AS
group. Ratios obtained using plasma native thiol, total thiol, and disulfide
levels differed significantly between the FMF, AS and the control groups.

Conclusion: The lower thiol level of FMF
group compared to AS and controls suggests that the thiol / disulfide balance
is affected differently in diseases with different pathophysiology. Although
the disease is in clinically inactive period, inflammation may continue at
different levels in different rheumatic diseases.

Anahtar Kelimeler

Ankylosing Spondylitis, Familial Mediterranean fever, Thiol/disulfide

Kaynakça

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