Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Özden Öz; Abdullah İnal

doi:10.17343/sdutfd.1615328

Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Öz

Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin & Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia (PH), pyloric metaplasia (PM), intestinal metaplasia (IM), epithelial dysplasia (ED), and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fisher’s exact test were used, and p <0.05 was considered significant. Results: The mean age of the patient was 53.17 ± 13.48. PH, PM, IM, PM+IM, ED, and invasive cancer were detected in 11.38%, 8.92%, 11.15%, 07.04%, 3.16%, and 0.47% of all cases, respectively. The mucosal pathologies were mostly observed over 50 years (p <0,05). The mass-forming lesion could not be detected among dysplasia cases (p <0.0001). Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

Anahtar Kelimeler

Etik Beyan

The Ethics Committee of the University of Izmir Democracy, Buca Seyfi Demirsoy Education and Research Hospital approved using primary tissue samples in this study (Reference Number: 2024/348, Date: December 30, 2024). This study adhered to the principles of the Helsinki Declaration and its subsequent amendments.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Patoloji

Bölüm

Araştırma Makalesi

Yazarlar

Özden Öz ^*
0000-0001-5601-1567
Türkiye

Abdullah İnal
0000-0001-9124-6011
Türkiye

Yayımlanma Tarihi

19 Haziran 2025

Gönderilme Tarihi

10 Ocak 2025

Kabul Tarihi

1 Haziran 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 32 Sayı: 2

DOI

https://doi.org/10.17343/sdutfd.1615328

IZ

https://izlik.org/JA86BU73ML

Kaynak Göster

RIS / Bibtex

APA

Öz, Ö., & İnal, A. (2025). Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. Medical Journal of Süleyman Demirel University, 32(2), 177-183. https://doi.org/10.17343/sdutfd.1615328

AMA

1.Öz Ö, İnal A. Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. SDÜ Tıp Fak Derg. 2025;32(2):177-183. doi:10.17343/sdutfd.1615328

Chicago

Öz, Özden, ve Abdullah İnal. 2025. “Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient”. Medical Journal of Süleyman Demirel University 32 (2): 177-83. https://doi.org/10.17343/sdutfd.1615328.

EndNote

Öz Ö, İnal A (01 Haziran 2025) Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. Medical Journal of Süleyman Demirel University 32 2 177–183.

IEEE

[1]Ö. Öz ve A. İnal, “Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient”, SDÜ Tıp Fak Derg, c. 32, sy 2, ss. 177–183, Haz. 2025, doi: 10.17343/sdutfd.1615328.

ISNAD

Öz, Özden - İnal, Abdullah. “Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient”. Medical Journal of Süleyman Demirel University 32/2 (01 Haziran 2025): 177-183. https://doi.org/10.17343/sdutfd.1615328.

JAMA

1.Öz Ö, İnal A. Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. SDÜ Tıp Fak Derg. 2025;32:177–183.

MLA

Öz, Özden, ve Abdullah İnal. “Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient”. Medical Journal of Süleyman Demirel University, c. 32, sy 2, Haziran 2025, ss. 177-83, doi:10.17343/sdutfd.1615328.

Vancouver

1.Özden Öz, Abdullah İnal. Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. SDÜ Tıp Fak Derg. 01 Haziran 2025;32(2):177-83. doi:10.17343/sdutfd.1615328